MTOR SIGNALING PATHWAY (PW:0000180)

View Ontology Report

Description

mTOR signaling pathway responds to and integrates a range of environmental cues and is known for its role in the control of protein translation and ribosome biogenesis, autophagy, cytoskeleton, and metabolism. The highly conserved Ser/Thr mTOR kinase is found in two distinct complexes: the rapamycin-sensitive mTORC1 and the largely rapamycin-insensitive mTORC2. Rapamycin (sirolimus) - a macrolide produced by Streptomyces Hygroscopicus, in complex with Fkbp1a (the 12-kDa FK506-binding prot

Pathway Diagram:

Ariadne Genomics Inc. Tsc2 insulin signaling pathway Rrag members mTorc1 mTorc2 translation initiation pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway --+> Tsc2 mTorc2 --+> phosphatidylinositol 3-kinase-Akt signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway GF --+> mTorc2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Tsc2 ---| Rheb Rheb --+> mTorc1 mTorc2 --+> cytoskeletal rearrangements cytoskeletal rearrangements Rps6kb2 --+> ribosome biogenesis and assembly Rps6kb2 --+> translation initiation pathway Eif4ebp1 ---| translation initiation pathway mTorc1 --+> Rps6kb1 mTorc1 --+> Rps6kb2 phosphatidylinositol 3-kinase-Akt signaling pathway ---| Akt1s1 Rps6kb1 ---| Irs1 Rps6kb1 Eif4ebp1 mTorc1 ---| Eif4ebp1 adenosine monophosphate-activated protein kinase (AMPK) signaling pathway ---| mTorc1 Akt1s1 Akt1s1 ---| mTorc1 Rrag members --+> mTorc1 phosphatidylinositol 3-kinase-Akt signaling pathway ---| Tsc2 Tsc1 the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---| Tsc2 environmental cues --+> Rrag members environmental cues --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway insulin signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway insulin signaling pathway --+> phosphatidylinositol 3-kinase-Akt signaling pathway Irs1 ribosome biogenesis and assembly environmental cues GF Rheb Rps6kb2
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Genes in Pathway:

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mTOR signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
RGD:6907045
G Akt1s1 AKT1 substrate 1 JBrowse link 1 100,845,443 100,851,961 RGD:2308795
RGD:11535033
RGD:6484113
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:6484113
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:6484113
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6484113
RGD:6907045
G Cab39 calcium binding protein 39 JBrowse link 9 92,834,327 92,895,778 RGD:6907045
G Cab39l calcium binding protein 39-like JBrowse link 15 39,745,124 39,849,022 RGD:6907045
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 JBrowse link 14 84,447,552 84,457,396 RGD:11535047
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 JBrowse link 12 25,595,800 25,638,806 RGD:11535047
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6484113
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6484113
G Clip1 CAP-GLY domain containing linker protein 1 JBrowse link 12 38,345,203 38,452,650 RGD:6484113
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6484113
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6484113
RGD:6907045
G Depdc5 DEP domain containing 5 JBrowse link 14 83,089,000 83,219,576 RGD:11535043
G Deptor DEP domain containing MTOR-interacting protein JBrowse link 7 94,795,161 95,000,750 RGD:6484113
RGD:11535033
G Eef2 eukaryotic translation elongation factor 2 JBrowse link 7 11,401,501 11,406,771 RGD:6484113
G Eef2k eukaryotic elongation factor-2 kinase JBrowse link 1 190,780,211 190,839,926 RGD:6484113
G Eif4a1 eukaryotic translation initiation factor 4A1 JBrowse link 10 56,271,257 56,276,764 RGD:6484113
G Eif4b eukaryotic translation initiation factor 4B JBrowse link 7 143,679,656 143,701,452 RGD:6484113
RGD:6907045
G Eif4e eukaryotic translation initiation factor 4E JBrowse link 2 243,819,616 243,853,987 RGD:6484113
RGD:6907045
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 JBrowse link 9 94,310,476 94,325,445 RGD:6907045
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:1625616
RGD:6907045
RGD:6484113
RGD:2308795
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:6484113
G Fkbp1a FK506 binding protein 1a JBrowse link 3 147,042,944 147,062,725 RGD:11535033
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:11535042
G Fnip1 folliculin interacting protein 1 JBrowse link 10 39,786,687 39,870,188 RGD:11535042
G Fnip2 folliculin interacting protein 2 JBrowse link 2 178,223,561 178,334,925 RGD:11535042
G Hif1a hypoxia inducible factor 1 alpha subunit JBrowse link 6 96,810,868 96,856,303 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6484113
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6484113
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 JBrowse link 1 166,991,474 166,997,045 RGD:11535043
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 JBrowse link 2 187,911,530 187,914,930 RGD:11535043
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 JBrowse link 2 243,160,821 243,173,057 RGD:11535043
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 JBrowse link 12 19,573,909 19,577,625 RGD:11535043
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 JBrowse link 2 210,034,095 210,039,451 RGD:11535043
G Lpin1 lipin 1 JBrowse link 6 41,796,214 41,905,149 RGD:1641823
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6484113
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
RGD:6907045
G Mapkap1 mitogen-activated protein kinase associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:2308795
RGD:11535033
RGD:6484113
G Mios meiosis regulator for oocyte development JBrowse link 4 34,238,370 34,264,015 RGD:11535043
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:1626104
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1625611
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
RGD:2307383
RGD:1625616
G Nprl2 NPR2-like, GATOR1 complex subunit JBrowse link 8 116,297,950 116,301,123 RGD:11535043
G Nprl3 NPR3-like, GATOR1 complex subunit JBrowse link 10 15,620,824 15,661,332 RGD:11535043
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6484113
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
RGD:6907045
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:6484113
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:6484113
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:6484113
G Poldip3 DNA polymerase delta interacting protein 3 JBrowse link 7 123,992,167 124,020,596 RGD:6484113
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6484113
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6907045
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6484113
G Prr5 proline rich 5 JBrowse link 7 125,569,791 125,609,340 RGD:6484113
RGD:11535033
G Prr5l proline rich 5 like JBrowse link 3 91,290,207 91,461,208 RGD:11535033
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6484113
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6484113
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6484113
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:6484113
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:1625606
RGD:11535034
RGD:6907045
RGD:6484113
RGD:2308795
RGD:1625616
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:1625616
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
RGD:2307383
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6907045
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:6484113
RGD:6907045
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:6907045
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:6907045
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:6907045
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:1625616
RGD:6907045
RGD:6484113
RGD:2308795
RGD:1626103
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:1625616
RGD:6907045
RGD:2308795
RGD:1626103
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1625616
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
RGD:2307383
G Rraga Ras-related GTP binding A JBrowse link 5 104,941,067 104,942,662 RGD:2308795
RGD:11535043
RGD:6484113
G RragB Ras-related GTP binding B JBrowse link X 19,085,913 19,135,049 RGD:2308795
RGD:11535043
RGD:6484113
G Rragb_v1 Ras-related GTP binding B, variant 1 RGD:2308795
G Rragc Ras-related GTP binding C JBrowse link 5 141,572,536 141,590,784 RGD:2308795
RGD:11535043
RGD:6484113
G Rragd Ras-related GTP binding D JBrowse link 5 48,224,994 48,260,691 RGD:2308795
RGD:11535043
RGD:6484113
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor JBrowse link 10 3,170,387 3,214,648 RGD:6484113
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:11535042
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6484113
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6484113
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6907045
G Strada STE20-related kinase adaptor alpha JBrowse link 10 94,355,369 94,384,404 RGD:6907045
G Tbc1d7 TBC1 domain family, member 7 JBrowse link 17 23,774,793 23,792,389 RGD:11535034
G Telo2 telomere maintenance 2 JBrowse link 10 14,461,581 14,476,812 RGD:11535033
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:1625616
RGD:11535034
RGD:6907045
RGD:6484113
RGD:2308795
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580520
RGD:11535034
RGD:6907045
RGD:6484113
RGD:2308795
RGD:1625616
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:1625616
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:1625616
G Tti1 TELO2 interacting protein 1 JBrowse link 3 154,463,108 154,506,955 RGD:11535033
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:6484113
RGD:6907045
G Ulk2 unc-51 like autophagy activating kinase 2 JBrowse link 10 48,050,079 48,129,377 RGD:6484113
RGD:6907045
G Ulk3 unc-51 like kinase 3 JBrowse link 8 62,368,548 62,375,229 RGD:6907045
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Wdr24 WD repeat domain 24 JBrowse link 10 15,191,078 15,195,860 RGD:11535043
G Wdr59 WD repeat domain 59 JBrowse link 19 43,651,686 43,714,391 RGD:11535043
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta JBrowse link 3 160,391,108 160,399,931 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6484113
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:6484113
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6484113
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6484113
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexmTORC1 complexmTOR complex 1
ComplexmTORC2 complexmTOR complex 2

Pathway Gene Annotations

Disease Annotations Associated with Genes in the mTOR signaling pathway
Disease TermsGene Symbols
Fetal Alcohol SyndromeRhoa
Pathway Annotations Associated with Genes in the mTOR signaling pathway
Pathway TermsGene Symbols
activin signaling pathwayFkbp1a
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pml , Raf1 , Rps6kb1 , Rps6kb2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCab39 , Prkaa1 , Prkaa2 , Stk11 , Strada
adenosine signaling pathwayAkt1 , Braf , Hras , Ikbkb , Map2k2 , Mapk1 , Pdpk1 , Pik3ca , Rps6ka1
aldosterone signaling pathwayIgf1 , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Sfn , Sgk1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin signaling pathwayIns2
altered insulin-like growth factor signaling pathwayIgf1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
Alzheimer disease pathwayCycs , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayCycs , Rac1
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Arf family mediated signaling pathwayPld2 , Rac1
autophagy pathwayAtg13 , Ins1 , Ins2 , Prkaa1 , Prkaa2 , Rb1cc1 , Ulk1 , Ulk2 , Ulk3
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1
bevacizumab pharmacodynamics pathwayVegfa
bladder cancer pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Bone morphogenetic proteins signaling pathwayMapk1
c-Jun N-terminal kinases MAPK signaling pathwayRac1
calcium signaling pathway via the calcium-sensing receptorRhoa
calcium/calcium-mediated signaling pathwayPrkca
cardiolipin metabolic pathwayCycs
cardiovascular system disease pathwayIgf1
cell cycle pathway, mitoticCcne1 , Cdk2 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Igf1 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pxn , Rac1 , Raf1 , Rhoa
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa
corticosteroid signaling pathwaySgk1
CRM1 export pathwayEif4e
cytokine mediated signaling pathwayVegfc , Vegfd
dilated cardiomyopathy pathwayIgf1
E-cadherin signaling pathwayAkt1 , Akt2 , Igf1 , Pik3ca , Pik3r1 , Rac1 , Rhoa
eicosanoid signaling pathwayAkt1 , Pik3r5 , Prkca , Rac1 , Rhoa
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
electron transport chain pathwayCycs
endocytosis pathwayHras , Pld1 , Pld2 , Pml , Rhoa
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkca , Rac1 , Raf1 , Rhoa
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca
ephrin - ephrin receptor bidirectional signaling axisHras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5 , Pxn , Rac1 , Rhoa
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1 , Rps6kb1 , Rps6kb2
erythropoietin signaling pathwayHras , Pik3r1
ether lipid metabolic pathwayPld1 , Pld2
ether lipid metabolic pathwayPld1 , Pld2
FasL mediated signaling pathwayAkt1 , Ikbkb , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Rac1 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pld2 , Prkca , Rac1 , Raf1 , Rps6kb1 , Rps6kb2
fibroblast growth factor signaling pathwayAkt1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Rps6ka1
forkhead class A signaling pathwayAkt1 , Ins2
G1/S DNA damage checkpoint pathwayCcne1
G1/S transition pathwayCcne1 , Cdk2
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
glutamate signaling pathwayMapk1 , Mapk3 , Pld1 , Pld2 , Prkca
glyburide pharmacodynamics pathwayIns2
glycerophospholipid metabolic pathwayPld1 , Pld2
glypican signaling pathwayVegfa
gonadotropin-releasing hormone signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pld1 , Pld2 , Prkca , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayHras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Ywhaz
Hedgehog signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Sspo
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
histone modification pathwayYwhaz
Huntington disease pathwayCycs , Ppargc1a
hypertrophic cardiomyopathy pathwayIgf1 , Prkaa1 , Prkaa2
hypoxia inducible factor pathwayAkt1 , Bnip3 , Hif1a , Vegfa
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pml , Prkca , Raf1
INO80 family mediated chromatin remodeling pathwayYy1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Ins2 , Rac1 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4e , Eif4e2 , Eif4ebp1 , Hras , Ikbkb , Ins1 , Ins2 , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Raf1 , Rheb , Rps6 , Rps6kb1 , Rps6kb2 , Rptor , Sgk1 , Srebf1 , Tsc1 , Tsc2
insulin-like growth factor signaling pathwayAkt1 , Hras , Igf1 , Irs1 , Pdpk1 , Pik3ca , Pik3r1 , Pxn , Raf1 , Rps6kb1 , Ywhae , Ywhaz
integrin mediated signaling pathwayPxn
interleukin-1 signaling pathwayIkbkb , Pik3ca , Pik3r1
interleukin-12 signaling pathwayMtor
interleukin-2 signaling pathwayCdk2 , Hras , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Rhoa
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1 , Ywhag , Ywhaz
interleukin-4 signaling pathwayAkt1 , Irs1 , Mtor , Pik3ca , Pik3r1 , Rps6kb1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pik3ca , Pik3r1 , Rac1
intrinsic apoptotic pathwayBnip3 , Cycs
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Leishmania infection pathwayMapk1 , Mapk3
leptin system pathwayIrs1
long term depressionBraf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Raf1
long term potentiationBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6
maturity onset diabetes of the young pathwayIns1 , Ins2
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccne1 , Cdk2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitochondrial autophagy pathwayBnip3 , Ulk1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Rac1 , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
mTOR signaling pathwayAkt1 , Akt1s1 , Akt2 , Akt3 , Atg13 , Bnip3 , Braf , Cab39 , Cab39l , Castor1 , Castor2 , Ccne1 , Cdk2 , Clip1 , Cycs , Ddit4 , Depdc5 , Deptor , Eef2 , Eef2k , Eif4a1 , Eif4b , Eif4e , Eif4e2 , Eif4ebp1 , Fbxw11 , Fkbp1a , Flcn , Fnip1 , Fnip2 , Hif1a , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Irs1 , Lamtor1 , Lamtor2 , Lamtor3 , Lamtor4 , Lamtor5 , Lpin1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapkap1 , Mios , Mlst8 , Mtor , Nprl2 , Nprl3 , Nras , Pdcd4 , Pdpk1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pld2 , Pml , Poldip3 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Prr5 , Prr5l , Pxn , Rac1 , Raf1 , Rb1cc1 , Rheb , Rhoa , Rictor , Rps6 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Rps6kb1 , Rps6kb2 , Rptor , Rraga , RragB , Rragb_v1 , Rragc , Rragd , Rrn3 , Sesn2 , Sfn , Sgk1 , Srebf1 , Sspo , Stk11 , Strada , Tbc1d7 , Telo2 , Tsc1 , Tsc2 , Tsc2_v1 , Tsc2_v2 , Tti1 , Ulk1 , Ulk2 , Ulk3 , Vegfa , Vegfb , Vegfc , Vegfd , Wdr24 , Wdr59 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz , Yy1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Cycs , Mapk1 , Mapk3 , Raf1 , Rhoa
myocarditis pathwayCycs , Rac1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Rac1 , Rhoa
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
NOD-like receptor signaling pathwayIkbkb , Mapk1 , Mapk3
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
Notch signaling pathwaySspo , Yy1
nuclear factor kappa B signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca , Sspo
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
p38 MAPK signaling pathwayRac1
p53 signaling pathwayAkt1 , Ccne1 , Cdk2 , Cycs , Igf1 , Sfn , Tsc2 , Yy1
p53-dependent G1/S DNA damage checkpoint pathwayCcne1
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Parkinson disease pathwayCycs
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rhoa , Sgk1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Rictor , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Rac1 , Raf1 , Rhoa , Rps6ka3 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
potassium channel inhibitors pharmacodynamics pathwayIns2
prion diseases pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Ccne1 , Cdk2 , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
protein kinase C (PKC) signaling pathwayPdpk1 , Prkca
Reelin signaling pathwayAkt1 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Flcn , Hif1a , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb
Rheb mediated signaling pathwayRheb
rheumatoid arthritis disease pathwayPgf , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayRac1 , Rhoa
RNA polymerase I transcription pathwayRrn3
RNA transport pathwayEif4a1 , Eif4b , Eif4e , Eif4e2 , Eif4ebp1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Ccne1 , Cdk2 , Cycs , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Irs1 , Mapk1 , Mapk3 , Rac1 , Rhoa , Vegfa
sterol regulatory element-binding protein signaling pathwaySrebf1
syndecan signaling pathwayHras , Mapk1 , Mapk3 , Prkca , Rac1 , Rhoa
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rhoa
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
thyroid cancer pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayFkbp1a , Pdpk1 , Pml , Rhoa , Rps6kb1 , Ywhae
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Rhoa , Rps6kb1 , Rps6kb2
translation elongation pathwayEef2
translation initiation pathwayEif4a1 , Eif4b , Eif4e
Trypanosoma brucei infection pathwayPrkca
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
tumor necrosis factor mediated signaling pathwayIkbkb
type 1 diabetes mellitus pathwayIns1 , Ins2
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayFbxw11 , Pml
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Fbxw11 , Hif1a , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaa1 , Prkaa2 , Prkca , Pxn , Rac1 , Raf1 , Rhoa , Vegfa , Vegfb , Vegfc , Vegfd
Wnt signaling pathwayFbxw11 , Prkca , Rac1 , Rhoa
Wnt signaling, canonical pathwayTsc2
Wnt signaling, non-canonical pathwayRac1 , Rhoa
Wnt signaling, the planar cell polarity pathwayRac1 , Rhoa
Phenotype Annotations Associated with Genes in the mTOR signaling pathway

References Associated with the mTOR signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: