PHOSPHATIDYLINOSITOL 3-KINASE-AKT SIGNALING PATHWAY (PW:0000232)

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Description

The phosphatidylinositol 3-kinase-Akt signaling pathway plays a crucial role in many cellular processes. The PI3K generally referenced is the class IA lipid kinase acting downstream of receptor tyrosine kinases (RTKs). PI3Ks represent a large family of lipid kinases that phosphorylate the 3-hydroxy group of the inositol ring of membrane phosphatidylinositols (PtsIns). Based on substrate preferences and sequence similarity they are divided into three classes: class I, II and III. Class I is furth

Pathway Diagram:

Ariadne Genomics Inc. PS473 PT308 P-tyrosine receptor tyrosine kinase activated Akt members Pi3k-Akt cytoplasmic targets Pi3k-Akt nuclear targets activated Akt members --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway activated Akt members --+> mTOR signaling pathway mTOR signaling pathway insulin responsive facilitative sugar transporter mediated glucose transport pathway activated Akt members ---| forkhead signaling pathway Akt3 Akt2 Akt1 PIP3 PIP2 Inpp5d ---| PIP3 Pten ---| PIP3 cell survival pro-growth Inppl1 ---| PIP3 Pten Pdpk1 Pik3ca Pik3ca --+> PIP2 Pdpk1 --+> Akt1 a second kinase a second kinase --+> Akt1 cell proliferation activated Akt members ---> cell survival activated Akt members ---> pro-growth activated Akt members ---> cell proliferation Pik3r1 Pik3r2 Pik3r3 Pik3cb Pik3cd Inpp5d Inppl1 forkhead signaling pathway
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Genes in Pathway:

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phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:625444
RGD:6484113
RGD:2290458
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:632179
RGD:6484113
RGD:2290458
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:2290458
RGD:6484113
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6484113
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6484113
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6484113
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6484113
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6484113
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:6484113
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6484113
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:2302068
G Inppl1 inositol polyphosphate phosphatase-like 1 JBrowse link 1 166,898,177 166,912,524 RGD:2302068
G Kpna1 karyopherin subunit alpha 1 JBrowse link 11 67,652,573 67,717,180 RGD:6484113
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
G Mapkap1 mitogen-activated protein kinase associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:6484113
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:6484113
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:2290458
RGD:6484113
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:11535053
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 19 41,731,845 41,798,451 RGD:11535053
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:2290458
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:2290458
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:2290458
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:2290458
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:2290458
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:2290458
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:11535052
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:11535052
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:11535052
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:11535052
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:11535052
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
G Prkdc protein kinase, DNA activated, catalytic polypeptide JBrowse link 11 89,293,547 89,510,948 RGD:6484113
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2290458
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6484113
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:6484113
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6484113
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta JBrowse link 3 160,391,108 160,399,931 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6484113
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:6484113
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6484113
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6484113
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:2313763
RGD:5133243
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313763
RGD:2313408
RGD:5490965
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:2313763
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:2313763
RGD:5133243
RGD:5133242
RGD:4143515
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2313763
RGD:5490965
RGD:5133242
RGD:4143515
RGD:2326139

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupPi3k-Akt cytoplasmic targets
Functional Classactivated Akt members
Gene GroupAkt nuclear targets

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Chuk , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp2ca
adenosine signaling pathwayAkt1 , Bad , Chuk , Pdpk1 , Pik3ca
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
aldosterone signaling pathwayHsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Sfn
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayRaf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Reelin signaling pathwaySrc
Alzheimer disease pathwayBad , Casp9 , Gsk3b
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
amyotrophic lateral sclerosis disease pathwayBad , Casp9
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPdpk1
antigen processing and presentation pathwayHsp90aa1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Gsk3b , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
basal cell carcinoma pathwayGsk3b
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca
bisoprolol pharmacodynamics pathwayPrkaca
bladder cancer pathwayCdkn1a , Raf1
Bone morphogenetic proteins signaling pathwayGsk3b
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
calcium/calcium-mediated signaling pathwayPrkaca
calcium/calmodulin dependent kinase 2 signaling pathwayPpp2ca
carvedilol pharmacodynamics pathwayPrkaca
cell cycle pathway, mitoticCdkn1a , Cdkn1b , Gsk3b , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Foxo3 , Gsk3a , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
cortisol signaling pathwayHsp90aa1
dilated cardiomyopathy pathwayPrkaca
diltiazem pharmacodynamics pathwayPrkaca
disopyramide pharmacodynamics pathwayPrkaca
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayPpp2ca , Ppp2cb , Prkaca , Src
E-cadherin signaling pathwayAkt1 , Akt2 , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayAkt1 , Prkaca , Src
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwaySrc
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Gsk3b , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
endothelin signaling pathwayAkt1 , Raf1 , Src
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca
ephrin - ephrin receptor bidirectional signaling axisInppl1 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Gsk3b , Hsp90aa1 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Src
erythropoietin signaling pathwayInpp5d , Pik3r1
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwayHsp90aa1 , Src
facilitative sugar transporter mediated glucose transport pathwaySlc2a4
FasL mediated signaling pathwayAkt1 , Chuk , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3r1 , Src
flecainde pharmacodynamics pathwayPrkaca
forkhead class A signaling pathwayAkt1 , Cdkn1b
fosphenytoin pharmacodynamics pathwayPrkaca
G1/S transition pathwayCdkn1a , Cdkn1b
glioma pathwayAkt1 , Akt2 , Akt3 , Cdkn1a , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
glutamate signaling pathwayPrkaca
glycogen biosynthetic pathwayGsk3a , Gsk3b
glypican signaling pathwaySrc
gonadotropin-releasing hormone signaling pathwayPrkaca , Raf1 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayInpp5d , Pik3ca , Pik3r1 , Prkaca , Raf1 , Ywhaz
Hedgehog signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Prkaca
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a , Raf1
histone modification pathwayYwhaz
Huntington disease pathwayCasp9
hypoxia inducible factor pathwayAkt1
ibutilide pharmacodynamics pathwayPrkaca
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Gsk3b , Kpna1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayInppl1 , Pik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b , Sfn , Slc2a4 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo1 , Foxo3 , Gsk3b , Inpp5d , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Slc2a4
insulin-like growth factor signaling pathwayAkt1 , Bad , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Ywhae , Ywhaz
interleukin-1 signaling pathwayChuk , Pik3ca , Pik3r1
interleukin-12 signaling pathwayMtor
interleukin-2 signaling pathwayPik3ca , Pik3r1 , Raf1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayInpp5d , Pik3ca , Pik3r1 , Prkaca , Ywhag , Ywhaz
interleukin-4 signaling pathwayAkt1 , Inpp5d , Mtor , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Foxo1 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBad , Casp9
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
levobunolol pharmacodynamics pathwayPrkaca
lidocaine pharmacodynamics pathwayPrkaca
long term depressionGsk3b , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Raf1
long term potentiationPrkaca , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Cdkn1b , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Prkaca , Raf1
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Rictor , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Raf1 , Src
myocarditis pathwayCasp9
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayPrkaca
nebivolol pharmacodynamics pathwayPrkaca
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo3 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
NOD-like receptor signaling pathwayChuk , Hsp90aa1
non-homologous end joining pathway of double-strand break repairPrkdc
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Notch signaling pathwayCdkn1a
nuclear factor kappa B signaling pathwayChuk , Pik3ca , Pik3r1 , Src
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Gsk3a , Gsk3b , Pten
p38 MAPK signaling pathwayMap3k5
p53 signaling pathwayAkt1 , Casp9 , Cdkn1a , Gsk3b , Ppp2ca , Pten , Sfn
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Parkinson disease pathwayCasp9
penbutolol pharmacodynamics pathwayPrkaca
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hsp90aa1 , Inpp5d , Inppl1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Src
phosphatidylinositol 3-kinase signaling pathwayInpp5d , Inppl1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Foxo3 , Foxo4 , Gsk3a , Gsk3b , Hsp90aa1 , Inpp5d , Inppl1 , Kpna1 , Map3k5 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Phlpp1 , Phlpp2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a , Prkaca , Prkdc , Pten , Raf1 , Rictor , Sfn , Slc2a4 , Src , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
phosphoinositide metabolic pathwayInpp5d , Pik3ca , Pik3cd , Pik3r1 , Pten
pindolol pharmacodynamics pathwayPrkaca
platelet-derived growth factor signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2r1a , Pten , Raf1 , Sfn , Src , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion diseases pathwayPrkaca
procainamide pharmacodynamics pathwayPrkaca
propranolol pharmacodynamics pathwayPrkaca
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Gsk3b , Hsp90aa1 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
protein kinase A (PKA) signaling pathwayPrkaca
protein kinase C (PKC) signaling pathwayHsp90aa1 , Pdpk1 , Phlpp1 , Phlpp2
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Src
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Casp9 , Cdkn1b , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten
somatostatin signaling pathwaySrc
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Src
syndecan signaling pathwayPrkaca , Src
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayRaf1
timolol pharmacodynamics pathwayPrkaca
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayFoxo1 , Foxo3 , Foxo4 , Pdpk1 , Ppp2ca , Ppp2cb , Ppp2r2a , Ywhae
transforming growth factor-beta superfamily mediated signaling pathwayPpp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a
tumor necrosis factor mediated signaling pathwayChuk , Map3k5
type 2 diabetes mellitus pathwayAkt2 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Slc2a4
type II interferon signaling pathwayAkt1 , Mtor , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwaySrc
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Hsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Src
vasopressin signaling pathway via receptor type 2Prkaca
verapamil pharmacodynamics pathwayPrkaca
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayGsk3b , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Prkaca
Wnt signaling, canonical pathwayGsk3a , Gsk3b
Phenotype Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway

References Associated with the phosphatidylinositol 3-kinase-Akt signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: