NUCLEAR FACTOR, ERYTHROID 2 LIKE 2 SIGNALING PATHWAY (PW:0000369)

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Description

The nuclear factor, erythroid 2 like 2 (Nfe2l2, known as Nrf2) signaling pathway is one of the most important regulators of antioxidant and electrophilic stress responses. Upon activation, the Nrf2 transcription factor induces the expression of antioxidant, xenobiotic metabolism and cytoprotective genes and also controls the expression of genes involved in intermediary metabolism. Under unstressed conditions, Nrf2 is sequestered in the cytoplasm by the ubiquitin E3 ligase adaptor Keap1, and only

Pathway Diagram:

Elsevier Inc. Gsk3b Kelch-repeat BTB ---> CTR Neh6 Neh2 ---- Neh3 Keap1 Pten Sqstm1 mTorc1 complex electrophiles ---| Pten ROS ---| Pten electrophiles ROS Btrc environmental cues cellular stresses Nfe2l2 target genes Cul3/Rbx1 complex ---| Nfe2l2 Skp1/Cul1/Rbx1 complex ---| Nfe2l2 Cul3/Rbx1 complex ---> Nfe2l2 Keap1 ---- Nfe2l2 small MAFs mTOR signaling pathway <++> phosphatidylinositol 3-kinase-Akt signaling pathway cellular stresses --+> phosphatidylinositol 3-kinase-Akt signaling pathway environmental cues --+> mTOR signaling pathway Skp1/Cul1/Rbx1 complex ---> Nfe2l2 Gsk3b --+> Btrc Crebbp ROS ---| Keap1 electrophiles ---| Keap1 nuclear Nfe2l2 nuclear Nfe2l2 ---- small MAFs Neh1 Gsk3b ---> Nfe2l2 Gsk3a ---> Nfe2l2 Btrc ---- Nfe2l2 phosphatidylinositol 3-kinase-Akt signaling pathway ---> Gsk3b phosphatidylinositol 3-kinase-Akt signaling pathway ---| Gsk3b phosphatidylinositol 3-kinase-Akt signaling pathway ---| Gsk3a phosphatidylinositol 3-kinase-Akt signaling pathway ---> Gsk3a IVR Gsk3a ROS --+> nuclear Nfe2l2 electrophiles --+> nuclear Nfe2l2 nuclear Nfe2l2 ---> Nfe2l2 target genes small MAFs ---> Nfe2l2 target genes Pten --+> Gsk3b Pten ---> Gsk3b Pten --+> Gsk3a Pten ---> Gsk3a C226/C613 preferring C273/C288 preferring C434 preferring CTR Skp1/Cul1/Rbx1 complex Nfe2l2 Nfe2l2 interactors ---> Nfe2l2 Keap1 ---- Keap1 interactors Keap1 interactors ---| Keap1 mTorc1 complex ---> Sqstm1 mTorc1 complex --+> Sqstm1 Neh7 Crebbp ---- Neh5 Crebbp ---- Neh4 Neh4 Neh5 Ncoa3 ---- Neh5 Ncoa3 ---- Neh4 Nfe2l2 ---- Nfe2l2 interactors Ncoa3 Chd6 Neh3 Chd6 ---- Neh3 C151 preferring 3-box BTB Neh2 mTOR signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway Cul3/Rbx1 complex Keap1 interactors Nfe2l2 interactors
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Genes in Pathway:

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nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:11535066
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:11535066
RGD:11535070
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:11535066
G Chd6 chromodomain helicase DNA binding protein 6 JBrowse link 3 156,937,746 157,099,328 RGD:11535066
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:11535066
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:11535066
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:11535066
G Dpp3 dipeptidylpeptidase 3 JBrowse link 1 220,166,124 220,189,762 RGD:11535066
G Gadd45gip1 GADD45G interacting protein 1 JBrowse link 19 25,946,979 25,949,528 RGD:11535066
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:11535070
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:11535070
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:11535066
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:727319
RGD:11535066
RGD:11530066
RGD:6902900
G Maff MAF bZIP transcription factor F JBrowse link 7 120,580,743 120,592,095 RGD:11535066
G Mafg MAF bZIP transcription factor G JBrowse link 10 109,802,877 109,811,476 RGD:11535066
G Mafk MAF bZIP transcription factor K JBrowse link 12 16,923,989 16,934,706 RGD:11535066
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:11535066
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11530066
RGD:11535070
RGD:11535066
G Palb2 partner and localizer of BRCA2 JBrowse link 1 192,064,586 192,088,547 RGD:11535066
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase JBrowse link 12 52,467,417 52,474,533 RGD:11535066
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:11535070
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:11535066
G Rnf4 ring finger protein 4 JBrowse link 14 81,658,400 81,679,756 RGD:11535066
G Siah2 siah E3 ubiquitin protein ligase 2 JBrowse link 2 148,874,151 148,891,900 RGD:11535066
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:11535066
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:11535066

Pathway Gene Annotations

Disease Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociGsk3b
Abnormalities, MultipleCrebbp , Gsk3b , Pten
Acute Kidney InjuryGsk3b , Nfe2l2
Acute Lung InjuryNfe2l2
AdenocarcinomaNcoa3 , Pten
Adenocarcinoma of LungCrebbp , Nfe2l2
ADENOCARCINOMA OF STOMACHCrebbp , Pten
Adenocarcinoma, ColorectalCdkn1a , Gsk3b
Adenocarcinoma, ProstaticPten
Adenoma, Liver CellPten
Aging, PrematureBrca1 , Cdkn1a , Nfe2l2
Alzheimer DiseaseCrebbp , Gsk3a , Gsk3b , Ikbkb , Nfe2l2
Amyotrophic Lateral SclerosisGsk3a , Gsk3b , Keap1 , Nfe2l2 , Sqstm1
Amyotrophic Lateral Sclerosis 1Crebbp
Angelman SyndromeRnf4
AngiomyolipomaPten
AnisometropiaPten
Arsenic PoisoningCdkn1a
Arthritis, ExperimentalGsk3b , Ikbkb
Arthritis, JuvenileMaff
AsthmaNfe2l2 , Pten
AstrocytomaNcoa3
AtaxiaPten
Atrial FibrillationCdkn1a
Attention Deficit Disorder with HyperactivityCrebbp
Autistic DisorderPten
Bannayan-Riley-Ruvalcaba syndromePten
Barrett EsophagusCdkn1a
Biliary AtresiaPten
Bipolar DisorderGsk3a , Gsk3b
bladder urothelial carcinomaCrebbp
Bone NeoplasmsNcoa3
Bowen's DiseaseCdkn1a
Brain InjuriesCdkn1a , Gsk3b , Nfe2l2
Brain NeoplasmsPten
breast cancerBrca1 , Palb2 , Pten
Breast Cancer, FamilialBrca1 , Palb2
breast carcinomaBrca1
Breast NeoplasmsBrca1 , Cdkn1a , Ikbkb , Ncoa3 , Palb2 , Pten
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Brca1
BurnsGsk3b
CarcinogenesisNfe2l2
CarcinomaBrca1 , Cdkn1a , Pten
Carcinoma in SituPten
Carcinoma, Adenoid CysticBrca1 , Crebbp , Pten
Carcinoma, Basal CellPalb2
Carcinoma, Ductal, BreastBrca1
Carcinoma, EndometrioidPten
Carcinoma, HepatocellularCrebbp , Nfe2l2 , Pten
Carcinoma, Intraductal, NoninfiltratingCdkn1a
Carcinoma, Non-Small-Cell LungKeap1 , Ncoa3 , Nfe2l2 , Pten
Carcinoma, Pancreatic DuctalCdkn1a , Nfe2l2
Carcinoma, Renal CellKeap1 , Nfe2l2 , Pten
Carcinoma, Squamous CellCdkn1a , Crebbp , Ncoa3 , Nfe2l2
Carcinoma, Squamous Cell of Head and NeckCrebbp , Nfe2l2 , Pten
Carcinoma, Transitional CellCdkn1a , Chd6 , Crebbp , Nfe2l2 , Pten
CardiomegalyGsk3b , Pten
Cardiomyopathy, DilatedGsk3a
CataractNfe2l2 , Pten
Cell Transformation, NeoplasticBrca1
Cerebral HemorrhageSqstm1
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b
Cervical Intraepithelial NeoplasiaBrca1 , Cdkn1a , Pten
Chemical and Drug Induced Liver InjuryKeap1 , Nfe2l2
CholangiocarcinomaPten
CholestasisNfe2l2
Cholestasis, IntrahepaticMafg
Cholesteatoma, CongenitalCdkn1a
Cholesteatoma, Middle EarCdkn1a
Choroidal NeovascularizationIkbkb
Chromosome BreakageBrca1 , Nfe2l2
Cognition DisordersGsk3b
ColitisIkbkb
Colitis, ExperimentalNfe2l2
Colonic NeoplasmsBrca1 , Cdkn1a , Gsk3b , Ikbkb , Pten
Colorectal NeoplasmsCrebbp , Nfe2l2 , Pten
Combined Oxidative Phosphorylation Deficiency 3Palb2
Congenital Myasthenic Syndrome IbBrca1
Craniofacial AbnormalitiesPten
Cystadenocarcinoma, SerousCdkn1a
Depressive DisorderGsk3a , Gsk3b
DermatitisIkbkb
Dermatitis, Allergic ContactNfe2l2
Developmental DisabilitiesPten
Diabetes MellitusPten
Diabetes Mellitus, ExperimentalCdkn1a , Gsk3a , Ikbkb , Nfe2l2
Diabetes Mellitus, Type 2Gsk3b , Ikbkb , Nfe2l2
Diabetic CardiomyopathiesNfe2l2
Diabetic NephropathiesKeap1 , Nfe2l2 , Pten
Diabetic RetinopathyKeap1 , Nfe2l2
Disease ProgressionKeap1 , Pten
Drug-Related Side Effects and Adverse ReactionsNfe2l2
DysgerminomaBrca1
EmphysemaNfe2l2
Encephalomyelitis, Autoimmune, ExperimentalNfe2l2
endometrial carcinomaPten
Endometrial HyperplasiaPten
Endometrial NeoplasmsCdkn1a , Gsk3b , Nfe2l2 , Pten
EndotoxemiaKeap1
Epilepsies, MyoclonicPalb2
Esophageal Atresia with or without Tracheoesophageal FistulaPalb2
Esophageal NeoplasmsCdkn1a
Esophageal Squamous Cell CarcinomaCdkn1a , Crebbp , Nfe2l2
Familial Paget's Disease of BoneSqstm1
Fanconi AnemiaBrca1 , Palb2
Fanconi anemia complementation group ABrca1
Fanconi Anemia, Complementation Group NPalb2
Fatty LiverKeap1 , Nfe2l2 , Pten
Fetal Alcohol Spectrum DisordersPten
Fetal Growth RetardationNfe2l2
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3Sqstm1
Fuchs' Endothelial DystrophyCdkn1a
Gallbladder NeoplasmsKeap1
Gastrointestinal DiseasesKeap1 , Nfe2l2
Gastrointestinal NeoplasmsPten
Genetic Diseases, InbornCrebbp , Pten
GlaucomaCrebbp
Glaucoma, Primary Open AngleCdkn1a
GlioblastomaCrebbp , Pten
GliomaPten
Growth Hormone-Secreting Pituitary AdenomaCdkn1a
Hamartoma Syndrome, MultiplePten
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a
Heart FailureGsk3b , Nfe2l2
HemangiomaPten
Hemangioma, Cavernous, Central Nervous SystemPten
HepatitisKeap1
Hepatitis B, ChronicKeap1
HepatomegalyPten
Hereditary Breast and Ovarian Cancer SyndromeBrca1 , Palb2
Hirschsprung Disease 1Crebbp
HIV InfectionsCdkn1a
Huntington DiseaseCrebbp , Nfe2l2
HyperglycemiaNfe2l2
HyperinsulinismPten
HyperoxiaCdkn1a
HyperplasiaBrca1 , Cdkn1a , Ikbkb , Nfe2l2
HypertensionBrca1 , Gsk3b , Ikbkb , Nfe2l2 , Pten , Sqstm1
Hypertension, PortalPten
Hypertension, PulmonaryCdkn1a
Hypertension, RenalCdkn1a
HypertrophyPten
Hypertrophy, Left VentricularGsk3a , Pten
HypovolemiaCdkn1a
Idiopathic Interstitial PneumoniasKeap1
Immunodeficiency 15Ikbkb
Infarction, Middle Cerebral ArteryIkbkb , Nfe2l2
Inflammatory Bowel Disease 11Cdkn1a
Inflammatory Bowel DiseasesIkbkb
Insulin ResistanceIkbkb , Pten
Intellectual DisabilityPten
Intestinal NeoplasmsCdkn1a , Gsk3b
Ischemic Attack, TransientIkbkb , Keap1 , Pten
Joubert SyndromeBrca1
Joubert Syndrome 17Brca1
Keratoconus 1Skp1
KeratosisKeap1 , Nfe2l2
Kidney DiseasesCdkn1a , Nfe2l2
Kidney Failure, ChronicKeap1
Kidney Reperfusion InjuryIkbkb
Language Development DisordersPten
Laryngeal NeoplasmsCdkn1a
LeiomyomaPten
Lens DiseasesSiah2
LEOPARD SyndromePten
LeukemiaNcoa3 , Pten
Leukemia, Megakaryoblastic, AcutePten
Leukemia, Myeloid, AcuteCrebbp
Leukoplakia, OralCdkn1a
Lichen Planus, OralCdkn1a
Lip NeoplasmsCdkn1a
LipomaPten
LipomatosisPten
liver cancerCrebbp
Liver CirrhosisNfe2l2
Liver Cirrhosis, BiliaryCdkn1a
Liver Cirrhosis, ExperimentalCdkn1a , Nfe2l2
Liver Diseases, AlcoholicKeap1
Liver NeoplasmsCdkn1a , Crebbp , Nfe2l2
Liver Neoplasms, ExperimentalCdkn1a
Liver Reperfusion InjuryNfe2l2
Long QT SyndromePten
Lung DiseasesNfe2l2
Lung NeoplasmsCdkn1a , Pten
Lymphatic MetastasisCdkn1a , Pten
LymphomaPten
Lymphoma, FollicularCrebbp
Lymphoma, Mantle-CellGsk3b
Lymphoma, T-CellCdkn1a
Macrocephaly Autism SyndromePten
Macular DegenerationCdkn1a , Nfe2l2 , Sqstm1
Malformations of Cortical Development, Group IIPten
Mammary Neoplasms, AnimalBrca1 , Cdkn1a
Mammary Neoplasms, ExperimentalBrca1 , Nfe2l2 , Pten
Maxillary Sinus NeoplasmsCdkn1a
MedulloblastomaCrebbp
MegalencephalyPten
MelanomaCdkn1a , Crebbp , Cul3 , Pten
Melanoma, Cutaneous Malignant, Susceptibility To, 1Pten
Melanoma, ExperimentalIkbkb
MeningiomaPten
Meningioma, FamilialPten
Mesothelioma, MalignantCdkn1a
Micronuclei, Chromosome-DefectiveNfe2l2
Motor Skills DisordersPten
Mouth DiseasesBrca1
Mouth NeoplasmsPten
Muscular AtrophyGsk3b , Ikbkb
Muscular DystrophiesPten
Muscular Dystrophy Congenital, Merosin NegativeBrca1
Muscular Dystrophy, FacioscapulohumeralCdkn1a
Muscular Dystrophy, Limb-Girdle, Type 2ABrca1
Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 11Brca1
Myocardial InfarctionGsk3b , Nfe2l2
Myocardial Reperfusion InjuryGsk3b , Nfe2l2 , Pten
Myoclonic Epilepsy, Familial InfantilePalb2
Nasopharyngeal CarcinomaPten
NecrosisNfe2l2
Neoplasm InvasivenessPten
Neoplasm MetastasisCdkn1a , Pten
NeoplasmsBrca1 , Pten
Neoplastic Syndromes, HereditaryBrca1 , Palb2 , Pten
Nephropathy, Chronic TubulointerstitialNfe2l2
Nephrosis, LipoidCdkn1a
Nerve Sheath NeoplasmsPten
NeuroblastomaChd6
NEURODEGENERATION WITH ATAXIA, DYSTONIA, AND GAZE PALSY, CHILDHOOD-ONSETSqstm1
Neurodevelopmental DisordersCul3 , Pten
Neuroma, AcousticCdkn1a
Neurotoxicity SyndromesNfe2l2
Non-alcoholic Fatty Liver DiseaseNfe2l2
Nonaka MyopathySqstm1
ObesityIkbkb , Ncoa3
Ocular HypertensionCdkn1a
Oral Squamous Cell CarcinomaCdkn1a
Orofaciodigital Syndrome 6Brca1
Osteitis DeformansSqstm1
OsteochondrodysplasiasPten
ovarian cancerBrca1 , Palb2
Ovarian NeoplasmsBrca1 , Cdkn1a , Gsk3b , Palb2 , Pten
pancreatic carcinoma Cdkn1a
Pancreatic NeoplasmsBrca1 , Palb2 , Pten
PancreatitisIkbkb
Pancreatitis, Experimental, Acute Cdkn1a
PapillomaCdkn1a
Papilloma, InvertedCdkn1a
Parkinson DiseaseGsk3b
Parkinsonian DisordersGsk3a
Peripheral Nervous System NeoplasmsPten
PeritonitisGsk3b
Phyllodes TumorCdkn1a
Pituitary NeoplasmsCdkn1a
PleurisyNfe2l2
PneumoniaIkbkb
PoisoningGsk3b
Polycystic Kidney, Autosomal DominantCdkn1a
PolydactylyPten
Porokeratosis punctata palmaris et plantarisBrca1
Precursor Cell Lymphoblastic Leukemia-LymphomaCrebbp
Primary Ovarian InsufficiencyNfe2l2
Prostate Cancer, SomaticPten
Prostatic HyperplasiaPten
Prostatic Intraepithelial NeoplasiaPten
Prostatic NeoplasmsBrca1 , Cdkn1a , Crebbp , Gsk3b , Keap1 , Ncoa3 , Nfe2l2 , Pten
Proteus SyndromePten
PseudohypoaldosteronismCul3
Pseudohypoaldosteronism, Type IIECul3
PsoriasisCdkn1a , Ikbkb
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
Pulmonary Disease, Chronic ObstructiveNfe2l2
Pulmonary EmphysemaKeap1 , Nfe2l2
Pulmonary FibrosisNfe2l2
Renal Insufficiency, ChronicNfe2l2
Reperfusion InjuryCdkn1a , Keap1 , Pten
Retinitis PigmentosaPten
RhabdomyosarcomaBrca1
Rubinstein-Taybi SyndromeCrebbp
Salivary Gland NeoplasmsCdkn1a
SarcoidosisCdkn1a
SarcopeniaCdkn1a
SchizophreniaGsk3a , Gsk3b
Scleroderma, LocalizedCdkn1a
ScoliosisCrebbp
Sebaceous Gland NeoplasmsCdkn1a
SeizuresNfe2l2 , Pten
SepsisCdkn1a , Gsk3b , Keap1
Severe Combined Immunodeficiency due to Adenosine Deaminase DeficiencyBrca1
Sezary SyndromeCrebbp , Pten
Sinonasal NeoplasmsCdkn1a
Skin DiseasesPten
Skin NeoplasmsCdkn1a , Nfe2l2
Small Cell Lung CarcinomaCrebbp , Pten
Smith-Magenis SyndromeBrca1 , Mafg
Spinal Cord InjuriesNfe2l2
Squamous Cell Carcinoma of the LungCrebbp , Nfe2l2 , Pten
Squamous Cell Carcinoma of the TongueCdkn1a
Status EpilepticusGsk3b
Stevens-Johnson SyndromeCul1 , Rbx1
Stomach DiseasesPten
Stomach NeoplasmsCdkn1a
Subarachnoid HemorrhageNfe2l2
Substance-Related DisordersPten
SunburnNfe2l2
TauopathiesGsk3b
Testicular NeoplasmsRnf4
Thumb DeformityCrebbp
Thyroid Cancer, FollicularPten
Thyroid NeoplasmsCdkn1a , Pten
Tongue NeoplasmsCdkn1a
Transplant RejectionIkbkb
Triple Negative Breast NeoplasmsPalb2
Tumor Predisposition SyndromeBrca1 , Palb2 , Pten
Ureteral ObstructionKeap1
Urinary Bladder NeoplasmsBrca1 , Cdkn1a , Chd6 , Crebbp , Pten
uterine carcinosarcomaPten
Uterine Cervical NeoplasmsBrca1 , Cdkn1a , Crebbp , Nfe2l2 , Pten
Uterine NeoplasmsNfe2l2 , Pten
VACTERL/VATER Association with HydrocephalusPten
Vascular System InjuriesNfe2l2
Pathway Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayIkbkb
adenosine signaling pathwayIkbkb
aldosterone signaling pathwayCrebbp
altered phosphatidylinositol 3-kinase signaling pathwayPten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPten
Alzheimer disease pathwayGsk3b
androgen signaling pathwayCrebbp , Ncoa3
apoptotic cell death pathwayIkbkb
ataxia telangiectasia-mutated (ATM) signaling pathwayBrca1 , Rnf4
B cell receptor signaling pathwayGsk3b , Ikbkb
basal cell carcinoma pathwayGsk3b
bladder cancer pathwayCdkn1a
Bone morphogenetic proteins signaling pathwayGsk3b
cell cycle pathway, mitoticCdkn1a , Crebbp , Cul1 , Gsk3b , Rbx1 , Skp1
ceramide signaling pathwayIkbkb
chemokine mediated signaling pathwayGsk3a , Gsk3b , Ikbkb
chronic myeloid leukemia pathwayCdkn1a , Ikbkb
colorectal cancer pathwayGsk3b
cortisol signaling pathwayCrebbp , Ncoa3
endometrial cancer pathwayGsk3b , Pten
Endoplasmic Reticulum-associated degradation pathwayCul1 , Nfe2l2 , Rbx1 , Skp1
epidermal growth factor/neuregulin signaling pathwayCdkn1a , Gsk3b
estrogen signaling pathwayCrebbp , Ncoa3 , Siah2
FasL mediated signaling pathwayIkbkb
forkhead class A signaling pathwayBrca1 , Crebbp , Ncoa3
G1/S transition pathwayCdkn1a
glioma pathwayCdkn1a , Pten
glycogen biosynthetic pathwayGsk3a , Gsk3b
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb
Hedgehog signaling pathwayBtrc , Crebbp , Gsk3b
hepatitis C virus infection pathwayCdkn1a , Gsk3b , Ikbkb
histone modification pathwayCrebbp
homologous recombination pathway of double-strand break repairBrca1
Huntington disease pathwayCrebbp
hypoxia inducible factor pathwayCrebbp , Rbx1
influenza A virus infection pathwayCrebbp , Gsk3b , Ikbkb
inositol phosphate metabolic pathwayPten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayGsk3b
insulin signaling pathwayGsk3b , Ikbkb
interleukin-1 signaling pathwayIkbkb , Sqstm1
Jak-Stat signaling pathwayCrebbp
long term depressionGsk3b
long term potentiationCrebbp
measles infection pathwayGsk3b
melanoma pathwayCdkn1a , Pten
mitochondrial autophagy pathwayPgam5 , Sqstm1
mitogen activated protein kinase signaling pathwayIkbkb
mTOR signaling pathwayIkbkb
Mycobacterium tuberculosis infection pathwayCrebbp
neddylation pathwayCul1 , Cul3 , Rbx1
neurotrophic factor signaling pathwayGsk3b , Ikbkb
NOD-like receptor signaling pathwayIkbkb
non-small cell lung cancer pathwayPten
Notch signaling pathwayCdkn1a , Crebbp , Cul1 , Skp1
nuclear factor kappa B signaling pathwayBtrc , Cul1 , Ikbkb , Rbx1 , Skp1
nuclear factor, erythroid 2 like 2 signaling pathwayBrca1 , Btrc , Cdkn1a , Chd6 , Crebbp , Cul1 , Cul3 , Dpp3 , Gadd45gip1 , Gsk3a , Gsk3b , Ikbkb , Keap1 , Maff , Mafg , Mafk , Ncoa3 , Nfe2l2 , Palb2 , Pgam5 , Pten , Rbx1 , Rnf4 , Siah2 , Skp1 , Sqstm1
nucleotide excision repair pathwayRbx1
p53 signaling pathwayBrca1 , Cdkn1a , Crebbp , Gsk3b , Pten
pancreatic cancer pathwayIkbkb , Pten
phosphatidylinositol 3-kinase class I signaling pathwayPten
phosphatidylinositol 3-kinase signaling pathwayPten
phosphatidylinositol 3-kinase-Akt signaling pathwayCdkn1a , Gsk3a , Gsk3b , Pten
phosphoinositide metabolic pathwayPten
platelet-derived growth factor signaling pathwayPten
prostate cancer pathwayCdkn1a , Crebbp , Gsk3b , Ikbkb , Pten
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1 , Cul3 , Rbx1
Reelin signaling pathwayGsk3b
renal cell cancer pathwayCrebbp , Rbx1
retinoic acid signaling pathwayNcoa3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb
RNA polymerase I transcription pathwayCrebbp
small cell lung cancer pathwayIkbkb , Pten
T cell receptor signaling pathwayGsk3b , Ikbkb
tamoxifen pharmacodynamics pathwayNcoa3
Toll-like receptor signaling pathwayIkbkb
Toxoplasma gondii infection pathwayIkbkb
Trail mediated signaling pathwayIkbkb
transforming growth factor-beta Smad dependent signaling pathwayCrebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Cul1 , Rbx1 , Skp1
Trypanosoma cruzi infection pathwayIkbkb
tumor necrosis factor mediated signaling pathwayIkbkb , Sqstm1
type 2 diabetes mellitus pathwayIkbkb
type II interferon signaling pathwayCrebbp
ubiquitin/proteasome degradation pathwayBrca1 , Btrc , Cul1 , Cul3 , Keap1 , Rbx1 , Skp1
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayBtrc , Crebbp , Cul1 , Gsk3b , Rbx1 , Skp1
Wnt signaling, canonical pathwayBtrc , Crebbp , Cul3 , Gsk3a , Gsk3b
Phenotype Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway

References Associated with the nuclear factor, erythroid 2 like 2 signaling pathway:

Ontology Path Diagram:

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