IRON HOMEOSTASIS PATHWAY (PW:0000590)

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Description

Iron (Fe) is essential for a wide range of important and vital processes as a component of heme- and iron-sulfur cluster (ISC)-containing proteins and as cofactor for non-heme iron-dependent enzymes. Very few life forms can survive in the absence of iron. Iron can be in its reduced, ferrous Fe(II)/Fe2+ form or in the oxidized, ferric Fe(III)/Fe3+ form. The redox cycling of iron underlies the chemistry of its biological functions. It also makes it potentially toxic, as it can lead to the producti

Pathway Diagram:

Elsevier Inc. Fe3+ ferritin complex ---- Slc11a2 Slc39a8 Slc11a2 ---> non-heme poly(rC) targets Cp Heph Hamp Slc40a1 Fbxl5 Ireb2-deg Ireb2 Aco1-ISC Aco1 Ftmt Slc25a28 Slc25a37 Ncoa4 dietary, non-heme Fe NTBI Fe2+ Slc39a14 Prnp Cybrd1 Steap3 eSlc11a2 Slc11a2 Tfrc Tf Aco1 ---| 5'-UTR IRE genes Ireb2 --+> 3'-UTR IRE genes autophagosome iron efflux pathway iron uptake pathway cytosolic iron-sulfur cluster protein assembly pathway mitochondrial iron-sulfur cluster protein biogenesis pathway heme biosynthetic pathway 3'-UTR IRE genes 5'-UTR IRE genes 5'-UTR IRE poly(rC) chaperones non-heme poly(rC) targets ferritin complex Tf ---- Tfrc Fe3+ ---- Tf NTBI ---> Slc11a2 dietary, non-heme Fe ---> Slc39a8 dietary, non-heme Fe ---> Slc39a14 Hamp ---- Slc40a1 5'-UTR IRE ---- Aco1 3'-UTR IRE ---- Aco1 5'-UTR IRE ---- Ireb2 3'-UTR IRE 3'-UTR IRE ---- Ireb2 Fbxl5 ---> Ireb2-deg Fbxl5 ---| Ireb2-deg ferritin complex ---- Ncoa4 ferritin complex ---> autophagosome Hamp ---| Slc40a1 non-heme poly(rC) targets ---- poly(rC) chaperones Fe2+ ---- poly(rC) chaperones poly(rC) chaperones ---- Slc11a2 ferritin complex ---- poly(rC) chaperones iron storage pathway
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Genes in Pathway:

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iron homeostasis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aco1 aconitase 1 JBrowse link 5 56,425,076 56,481,218 RGD:11554199
G Fbxl5 F-box and leucine-rich repeat protein 5 JBrowse link 14 71,852,649 71,891,143 RGD:11554199
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:11554199
G Ncoa4 nuclear receptor coactivator 4 JBrowse link 16 8,302,950 8,323,294 RGD:11554199
RGD:11556274
G Pcbp1 poly(rC) binding protein 1 JBrowse link 4 118,327,185 118,329,223 RGD:11554199
RGD:11556274
G Pcbp2 poly(rC) binding protein 2 JBrowse link 7 144,077,901 144,103,723 RGD:11554199
RGD:11556274
G Pcbp3 poly(rC) binding protein 3 JBrowse link 20 12,429,255 12,629,985 RGD:11554199
RGD:11556274
G Pcbp4 poly(rC) binding protein 4 JBrowse link 8 115,154,848 115,165,706 RGD:11554199
RGD:11556274
cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ciao1 cytosolic iron-sulfur assembly component 1 JBrowse link 3 119,671,778 119,677,324 RGD:11554190
RGD:11554192
G Ciapin1 cytokine induced apoptosis inhibitor 1 JBrowse link 19 10,596,923 10,612,414 RGD:11554190
RGD:11554192
G Fam96a family with sequence similarity 96, member A JBrowse link 8 71,786,336 71,798,258 RGD:11554190
RGD:11554192
G Fam96b family with sequence similarity 96, member B JBrowse link 19 551,708 553,573 RGD:11554190
RGD:11554192
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component JBrowse link 1 261,191,646 261,229,070 RGD:11554190
RGD:11554192
G Narfl nuclear prelamin A recognition factor-like JBrowse link 10 15,143,732 15,152,706 RGD:11554190
RGD:11554192
G Ndor1 NADPH dependent diflavin oxidoreductase 1 JBrowse link 3 2,466,698 2,474,928 RGD:11554190
RGD:11554192
G Nubp1 nucleotide binding protein 1 JBrowse link 10 5,333,378 5,343,949 RGD:11554190
RGD:11554192
G Nubp2 nucleotide binding protein 2 JBrowse link 10 14,244,201 14,247,930 RGD:11554190
RGD:11554192
heme biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1578396
RGD:11554188
RGD:4144542
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:1578396
RGD:11554188
RGD:4144542
RGD:1601233
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1578396
RGD:11554188
RGD:4144542
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:1578396
RGD:11554188
RGD:4144542
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1578396
RGD:11554188
RGD:4144542
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:1578396
RGD:11554188
RGD:4144542
RGD:2301704
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1578396
RGD:11554188
RGD:4144542
RGD:1599180
G Slc25a38 solute carrier family 25, member 38 JBrowse link 8 128,790,348 128,802,988 RGD:11554188
RGD:11556278
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:11554188
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:1578396
RGD:11554188
RGD:4144542
RGD:2303399
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:1578396
RGD:11554188
RGD:4144542
RGD:4144823
iron efflux pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:11534369
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:11534369
G Heph hephaestin JBrowse link X 65,377,313 65,658,479 RGD:11534369
G Slc40a1 solute carrier family 40 member 1 JBrowse link 9 52,819,451 52,830,461 RGD:11534369
iron storage pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fth1 ferritin heavy chain 1 JBrowse link 1 226,030,940 226,033,228 RGD:11554199
RGD:11556277
G Ftl1 ferritin light chain 1 JBrowse link 1 101,448,190 101,450,034 RGD:11554199
RGD:11556277
G Ftmt ferritin mitochondrial JBrowse link 18 47,294,292 47,295,541 RGD:11554199
G Pcbp1 poly(rC) binding protein 1 JBrowse link 4 118,327,185 118,329,223 RGD:11554199
RGD:11556274
G Pcbp2 poly(rC) binding protein 2 JBrowse link 7 144,077,901 144,103,723 RGD:11554199
RGD:11556274
iron uptake pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cybrd1 cytochrome b reductase 1 JBrowse link 3 57,718,496 57,745,749 RGD:11554199
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:11556274
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:11554199
G Slc25a28 solute carrier family 25 member 28 JBrowse link 1 263,420,039 263,431,312 RGD:11554199
G Slc25a37 solute carrier family 25 member 37 JBrowse link 15 51,125,764 51,168,384 RGD:11554199
G Slc39a14 solute carrier family 39 member 14 JBrowse link 15 51,982,872 52,029,841 RGD:11554199
RGD:11556274
G Slc39a8 solute carrier family 39 member 8 JBrowse link 2 241,028,851 241,092,584 RGD:11554199
RGD:11556274
G Steap3 STEAP3 metalloreductase JBrowse link 13 36,257,220 36,274,144 RGD:11554199
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:11554199
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:11554199
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb7 ATP binding cassette subfamily B member 7 JBrowse link X 75,150,511 75,291,950 RGD:11554190
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:11554190
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bola3 bolA family member 3 JBrowse link 4 115,046,693 115,056,140 RGD:11554190
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:11554190
G Fdx1l ferredoxin 1-like JBrowse link 8 22,086,534 22,091,450 RGD:11554190
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:11554190
G Glrx5 glutaredoxin 5 JBrowse link 6 128,750,503 128,760,880 RGD:11554190
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone JBrowse link 12 51,878,267 51,888,645 RGD:11554190
G Hspa9 heat shock protein family A member 9 JBrowse link 18 27,731,072 27,749,235 RGD:11554190
G Iba57 IBA57 homolog, iron-sulfur cluster assembly JBrowse link 10 45,506,124 45,514,909 RGD:11554190
G Isca1 iron-sulfur cluster assembly 1 JBrowse link 17 5,281,727 5,294,386 RGD:11554190
G Isca2 iron-sulfur cluster assembly 2 JBrowse link 6 108,488,678 108,490,188 RGD:11554190
G Iscu iron-sulfur cluster assembly enzyme JBrowse link 12 48,621,454 48,627,297 RGD:11554190
G Lyrm4 LYR motif containing 4 JBrowse link 17 29,439,042 29,552,773 RGD:11554190
G Nfs1 NFS1 cysteine desulfurase JBrowse link 3 151,665,813 151,688,151 RGD:11554190
G Nfu1 NFU1 iron-sulfur cluster scaffold JBrowse link 4 118,814,284 118,834,955 RGD:11554190
G Nubpl nucleotide binding protein-like JBrowse link 6 72,891,758 73,147,837 RGD:11554190

Pathway Gene Annotations

Disease Annotations Associated with Genes in the iron homeostasis pathway
Pathway Annotations Associated with Genes in the iron homeostasis pathway

References Associated with the iron homeostasis pathway:

Ontology Path Diagram:

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