IRON HOMEOSTASIS PATHWAY (PW:0000590)

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Description

Iron (Fe) is essential for a wide range of important and vital processes as a component of heme- and iron-sulfur cluster (ISC)-containing proteins and as cofactor for non-heme iron-dependent enzymes. Very few life forms can survive in the absence of iron. Iron can be in its reduced, ferrous Fe(II)/Fe2+ form or in the oxidized, ferric Fe(III)/Fe3+ form. The redox cycling of iron underlies the chemistry of its biological functions. It also makes it potentially toxic, as it can lead to the producti

Pathway Diagram:

Elsevier Inc. Fe3+ ferritin complex ---- Slc11a2 Slc39a8 Slc11a2 ---> non-heme poly(rC) targets Cp Heph Hamp Slc40a1 Fbxl5 Ireb2-deg Ireb2 Aco1-ISC Aco1 Ftmt Slc25a28 Slc25a37 Ncoa4 dietary, non-heme Fe NTBI Fe2+ Slc39a14 Prnp Cybrd1 Steap3 eSlc11a2 Slc11a2 Tfrc Tf Aco1 ---| 5'-UTR IRE genes Ireb2 --+> 3'-UTR IRE genes autophagosome iron efflux pathway iron uptake pathway cytosolic iron-sulfur cluster protein assembly pathway mitochondrial iron-sulfur cluster protein biogenesis pathway heme biosynthetic pathway 3'-UTR IRE genes 5'-UTR IRE genes 5'-UTR IRE poly(rC) chaperones non-heme poly(rC) targets ferritin complex Tf ---- Tfrc Fe3+ ---- Tf NTBI ---> Slc11a2 dietary, non-heme Fe ---> Slc39a8 dietary, non-heme Fe ---> Slc39a14 Hamp ---- Slc40a1 5'-UTR IRE ---- Aco1 3'-UTR IRE ---- Aco1 5'-UTR IRE ---- Ireb2 3'-UTR IRE 3'-UTR IRE ---- Ireb2 Fbxl5 ---> Ireb2-deg Fbxl5 ---| Ireb2-deg ferritin complex ---- Ncoa4 ferritin complex ---> autophagosome Hamp ---| Slc40a1 non-heme poly(rC) targets ---- poly(rC) chaperones Fe2+ ---- poly(rC) chaperones poly(rC) chaperones ---- Slc11a2 ferritin complex ---- poly(rC) chaperones iron storage pathway
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Genes in Pathway:

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iron homeostasis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aco1 aconitase 1 JBrowse link 5 56,425,076 56,481,218 RGD:11554199
G Fbxl5 F-box and leucine-rich repeat protein 5 JBrowse link 14 71,852,649 71,891,143 RGD:11554199
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:11554199
G Ncoa4 nuclear receptor coactivator 4 JBrowse link 16 8,302,950 8,323,294 RGD:11554199
RGD:11556274
G Pcbp1 poly(rC) binding protein 1 JBrowse link 4 118,327,185 118,329,223 RGD:11554199
RGD:11556274
G Pcbp2 poly(rC) binding protein 2 JBrowse link 7 144,077,901 144,103,723 RGD:11554199
RGD:11556274
G Pcbp3 poly(rC) binding protein 3 JBrowse link 20 12,429,255 12,629,985 RGD:11554199
RGD:11556274
G Pcbp4 poly(rC) binding protein 4 JBrowse link 8 115,154,848 115,165,706 RGD:11554199
RGD:11556274
cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ciao1 cytosolic iron-sulfur assembly component 1 JBrowse link 3 119,671,778 119,677,324 RGD:11554190
RGD:11554192
G Ciapin1 cytokine induced apoptosis inhibitor 1 JBrowse link 19 10,596,923 10,612,414 RGD:11554190
RGD:11554192
G Fam96a family with sequence similarity 96, member A JBrowse link 8 71,786,336 71,798,258 RGD:11554190
RGD:11554192
G Fam96b family with sequence similarity 96, member B JBrowse link 19 551,708 553,573 RGD:11554190
RGD:11554192
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component JBrowse link 1 261,191,646 261,229,070 RGD:11554190
RGD:11554192
G Narfl nuclear prelamin A recognition factor-like JBrowse link 10 15,143,732 15,152,706 RGD:11554190
RGD:11554192
G Ndor1 NADPH dependent diflavin oxidoreductase 1 JBrowse link 3 2,466,698 2,474,928 RGD:11554190
RGD:11554192
G Nubp1 nucleotide binding protein 1 JBrowse link 10 5,333,378 5,343,949 RGD:11554190
RGD:11554192
G Nubp2 nucleotide binding protein 2 JBrowse link 10 14,244,201 14,247,930 RGD:11554190
RGD:11554192
heme biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1578396
RGD:11554188
RGD:4144542
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:1578396
RGD:11554188
RGD:4144542
RGD:1601233
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1578396
RGD:11554188
RGD:4144542
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:1578396
RGD:11554188
RGD:4144542
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1578396
RGD:11554188
RGD:4144542
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:1578396
RGD:11554188
RGD:4144542
RGD:2301704
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1578396
RGD:11554188
RGD:4144542
RGD:1599180
G Slc25a38 solute carrier family 25, member 38 JBrowse link 8 128,790,348 128,802,988 RGD:11554188
RGD:11556278
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:11554188
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:1578396
RGD:11554188
RGD:4144542
RGD:2303399
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:1578396
RGD:11554188
RGD:4144542
RGD:4144823
iron efflux pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:11534369
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:11534369
G Heph hephaestin JBrowse link X 65,377,313 65,658,479 RGD:11534369
G Slc40a1 solute carrier family 40 member 1 JBrowse link 9 52,819,451 52,830,461 RGD:11534369
iron storage pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fth1 ferritin heavy chain 1 JBrowse link 1 226,030,940 226,033,228 RGD:11554199
RGD:11556277
G Ftl1 ferritin light chain 1 JBrowse link 1 101,448,190 101,450,034 RGD:11554199
RGD:11556277
G Ftmt ferritin mitochondrial JBrowse link 18 47,294,292 47,295,541 RGD:11554199
G Pcbp1 poly(rC) binding protein 1 JBrowse link 4 118,327,185 118,329,223 RGD:11554199
RGD:11556274
G Pcbp2 poly(rC) binding protein 2 JBrowse link 7 144,077,901 144,103,723 RGD:11554199
RGD:11556274
iron uptake pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cybrd1 cytochrome b reductase 1 JBrowse link 3 57,718,496 57,745,749 RGD:11554199
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:11556274
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:11554199
G Slc25a28 solute carrier family 25 member 28 JBrowse link 1 263,420,039 263,431,312 RGD:11554199
G Slc25a37 solute carrier family 25 member 37 JBrowse link 15 51,125,764 51,168,384 RGD:11554199
G Slc39a14 solute carrier family 39 member 14 JBrowse link 15 51,982,872 52,029,841 RGD:11554199
RGD:11556274
G Slc39a8 solute carrier family 39 member 8 JBrowse link 2 241,028,851 241,092,584 RGD:11554199
RGD:11556274
G Steap3 STEAP3 metalloreductase JBrowse link 13 36,257,220 36,274,144 RGD:11554199
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:11554199
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:11554199
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb7 ATP binding cassette subfamily B member 7 JBrowse link X 75,150,511 75,291,950 RGD:11554190
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:11554190
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bola3 bolA family member 3 JBrowse link 4 115,046,693 115,056,140 RGD:11554190
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:11554190
G Fdx1l ferredoxin 1-like JBrowse link 8 22,086,534 22,091,450 RGD:11554190
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:11554190
G Glrx5 glutaredoxin 5 JBrowse link 6 128,750,503 128,760,880 RGD:11554190
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone JBrowse link 12 51,878,267 51,888,645 RGD:11554190
G Hspa9 heat shock protein family A member 9 JBrowse link 18 27,731,072 27,749,235 RGD:11554190
G Iba57 IBA57, iron-sulfur cluster assembly JBrowse link 10 45,506,124 45,514,909 RGD:11554190
G Isca1 iron-sulfur cluster assembly 1 JBrowse link 17 5,281,727 5,294,386 RGD:11554190
G Isca2 iron-sulfur cluster assembly 2 JBrowse link 6 108,488,678 108,490,188 RGD:11554190
G Iscu iron-sulfur cluster assembly enzyme JBrowse link 12 48,621,454 48,627,297 RGD:11554190
G Lyrm4 LYR motif containing 4 JBrowse link 17 29,439,042 29,552,773 RGD:11554190
G Nfs1 NFS1 cysteine desulfurase JBrowse link 3 151,665,813 151,688,151 RGD:11554190
G Nfu1 NFU1 iron-sulfur cluster scaffold JBrowse link 4 118,814,284 118,834,955 RGD:11554190
G Nubpl nucleotide binding protein-like JBrowse link 6 72,891,758 73,147,837 RGD:11554190

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the iron homeostasis pathway

References Associated with the iron homeostasis pathway:

Ontology Path Diagram:

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