MITOGEN ACTIVATED PROTEIN KINASE SIGNALING PATHWAY (PW:0000007)

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Description

The mitogen activated protein kinase pathways (MAPKs) represent highly conserved cascades activated in response to effectors downstream of receptor tyrosine kinases (RTKs) or in some cases G-protein coupled receptors (GPCRs), and in response to inflammatory cytokines and stress. Together, they control many cellular processes. The hallmark of MAPK pathways is the shared architecture of a three-tier signaling core: MAP3K/MAP2K/MAPK. The downstream tier and main effectors MAPKs are activated by pho

Pathway Diagram:

Ariadne Genomics Inc. Erk5 MAPK signaling pathway p38 MAPK signaling pathway c-Jun N-terminal kinases MAPK signaling pathway The extracellular signal-regulated RAF/MEK/ERK pathway immune response motility apoptosis proliferation differentiation survival cytokine receptors RTK Rho Ras Traf effectors2 adapters effectors1 inflammatory cytokines GF stress conditions
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Genes in Pathway:

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mitogen activated protein kinase signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:6907045
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6907045
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:6907045
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6907045
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6907045
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6907045
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6907045
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6907045
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6907045
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:6907045
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:6907045
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:6907045
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:6907045
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:6907045
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 4 15,706,974 16,130,848 RGD:6907045
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:6907045
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 JBrowse link 16 4,871,348 5,795,825 RGD:6907045
G Cacna2d4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 JBrowse link 4 151,298,548 151,409,263 RGD:6907045
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:6907045
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:6907045
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:6907045
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:6907045
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 JBrowse link 10 95,921,479 95,934,170 RGD:6907045
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:6907045
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 JBrowse link 1 192,613,766 192,708,371 RGD:6907045
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 JBrowse link 10 95,954,160 96,015,484 RGD:6907045
G Cacng5 calcium voltage-gated channel auxiliary subunit gamma 5 JBrowse link 10 96,122,240 96,166,606 RGD:6907045
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 JBrowse link 1 64,307,684 64,322,124 RGD:6907045
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 JBrowse link 1 64,374,547 64,405,380 RGD:6907045
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 JBrowse link 1 64,330,106 64,350,338 RGD:6907045
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Ccdc88b coiled-coil domain containing 88B JBrowse link 1 222,102,436 222,118,485 RGD:6907045
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6907045
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Chp1 calcineurin-like EF-hand protein 1 JBrowse link 3 111,354,506 111,389,998 RGD:6907045
G Chp2 calcineurin-like EF hand protein 2 JBrowse link 1 192,169,634 192,173,228 RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6907045
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6907045
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:6907045
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:6907045
G Dusp14 dual specificity phosphatase 14 JBrowse link 10 71,363,688 71,383,602 RGD:6907045
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:6907045
G Dusp2 dual specificity phosphatase 2 JBrowse link 3 119,776,925 119,779,110 RGD:6907045
G Dusp22 dual specificity phosphatase 22 JBrowse link 17 34,986,589 35,037,297 RGD:6907045
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:6907045
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:6907045
G Dusp5 dual specificity phosphatase 5 JBrowse link 1 274,245,184 274,258,595 RGD:6907045
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:6907045
G Dusp7 dual specificity phosphatase 7 JBrowse link 8 115,069,095 115,076,130 RGD:6907045
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:6907045
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:6907045
G Ecsit ECSIT signalling integrator JBrowse link 8 23,085,598 23,099,064 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Elk4 ELK4, ETS transcription factor JBrowse link 13 48,788,262 48,813,267 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:1582137
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6907045
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6907045
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:6907045
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:6907045
G Fgf11 fibroblast growth factor 11 JBrowse link 10 56,403,320 56,410,816 RGD:6907045
G Fgf12 fibroblast growth factor 12 JBrowse link 11 75,606,360 76,171,078 RGD:6907045
G Fgf13 fibroblast growth factor 13 JBrowse link X 142,053,648 142,589,274 RGD:6907045
G Fgf14 fibroblast growth factor 14 JBrowse link 15 110,382,274 111,077,027 RGD:6907045
G Fgf16 fibroblast growth factor 16 JBrowse link X 76,786,728 76,796,311 RGD:6907045
G Fgf17 fibroblast growth factor 17 JBrowse link 15 52,326,758 52,337,360 RGD:6907045
G Fgf18 fibroblast growth factor 18 JBrowse link 10 18,047,109 18,082,290 RGD:6907045
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:6907045
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6907045
G Fgf20 fibroblast growth factor 20 JBrowse link 16 55,152,748 55,159,352 RGD:6907045
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:6907045
G Fgf22 fibroblast growth factor 22 JBrowse link 7 12,829,785 12,831,675 RGD:6907045
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:6907045
G Fgf3 fibroblast growth factor 3 JBrowse link 1 218,003,018 218,006,942 RGD:6907045
G Fgf4 fibroblast growth factor 4 JBrowse link 1 218,024,537 218,029,539 RGD:6907045
G Fgf5 fibroblast growth factor 5 JBrowse link 14 12,974,921 12,996,046 RGD:6907045
G Fgf6 fibroblast growth factor 6 JBrowse link 4 159,563,798 159,572,333 RGD:6907045
G Fgf7 fibroblast growth factor 7 JBrowse link 3 118,315,859 118,368,464 RGD:6907045
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:6907045
G Fgf9 fibroblast growth factor 9 JBrowse link 15 38,341,657 38,386,945 RGD:6907045
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:6907045
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6907045
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:6907045
G Fgfr4 fibroblast growth factor receptor 4 JBrowse link 17 9,990,072 10,004,339 RGD:6907045
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:6907045
G Flnb filamin B JBrowse link 15 18,750,152 18,883,019 RGD:6907045
G Flnc filamin C JBrowse link 4 56,710,934 56,738,779 RGD:6907045
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6907045
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6907045
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6907045
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6907045
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:6907045
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:6907045
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:6907045
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:6907045
G Hspa2 heat shock protein family A member 2 JBrowse link 6 99,433,575 99,436,288 RGD:6907045
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6907045
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6907045
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6907045
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:6907045
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Jund JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 16 20,485,028 20,486,707 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6907045
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6907045
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:6907045
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6907045
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:6907045
G Map3k12 mitogen activated protein kinase kinase kinase 12 JBrowse link 7 144,102,275 144,120,306 RGD:6907045
G Map3k13 mitogen-activated protein kinase kinase kinase 13 JBrowse link 11 82,744,391 82,938,357 RGD:6907045
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:6907045
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:6907045
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:6907045
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6907045
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:6907045
G Map3k6 mitogen-activated protein kinase kinase kinase 6 JBrowse link 5 151,435,679 151,448,329 RGD:6907045
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:6907045
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:6907045
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 JBrowse link 1 87,937,126 87,959,514 RGD:6907045
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 JBrowse link 1 221,710,622 221,726,274 RGD:6907045
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 JBrowse link 6 3,276,732 3,444,519 RGD:6907045
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 9 46,657,444 46,782,545 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:6907045
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:6907045
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:6907045
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:6907045
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:6907045
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:6907045
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:6907045
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6907045
G Max MYC associated factor X JBrowse link 6 99,984,260 100,011,460 RGD:6907045
G Mecom MDS1 and EVI1 complex locus JBrowse link 2 117,396,084 117,993,604 RGD:6907045
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:6907045
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:6907045
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:6907045
G Mos MOS proto-oncogene, serine/threonine kinase JBrowse link 5 16,746,085 16,747,392 RGD:6907045
G Mras muscle RAS oncogene homolog JBrowse link 8 107,629,028 107,656,851 RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:6907045
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:6907045
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:6907045
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:6907045
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6907045
G Nlk nemo like kinase JBrowse link 10 65,840,052 65,963,932 RGD:6907045
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 7 142,899,358 142,920,216 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6907045
G Ntf4 neurotrophin 4 JBrowse link 1 101,405,314 101,408,145 RGD:6907045
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:6907045
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6907045
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:70317
RGD:6907045
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6907045
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6907045
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6907045
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6907045
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:6907045
G Pla2g10 phospholipase A2, group X JBrowse link 10 1,509,732 1,520,970 RGD:6907045
G Pla2g12a phospholipase A2, group XIIA JBrowse link 2 235,311,664 235,327,972 RGD:6907045
G Pla2g12b phospholipase A2, group XIIB JBrowse link 20 28,989,440 29,007,967 RGD:6907045
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:6907045
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:6907045
G Pla2g2c phospholipase A2, group IIC JBrowse link 5 157,163,672 157,187,654 RGD:6907045
G Pla2g2d phospholipase A2, group IID JBrowse link 5 157,222,636 157,228,795 RGD:6907045
G Pla2g2f phospholipase A2, group IIF JBrowse link 5 157,192,047 157,217,265 RGD:6907045
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:6907045
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6907045
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:6907045
G Pla2g4e phospholipase A2, group IVE JBrowse link 3 111,952,396 112,018,470 RGD:6907045
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:6907045
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:6907045
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6907045
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:6907045
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:6907045
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:6907045
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:6907045
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:6907045
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6907045
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta JBrowse link 5 64,945,583 64,946,578 RGD:6907045
G Ppp5c protein phosphatase 5, catalytic subunit JBrowse link 1 78,944,054 78,968,361 RGD:6907045
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:6907045
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 JBrowse link 13 51,958,023 51,971,431 RGD:6907045
G Ptprr protein tyrosine phosphatase, receptor type, R JBrowse link 7 59,039,717 59,325,925 RGD:6907045
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6907045
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:6907045
G Rapgef2 Rap guanine nucleotide exchange factor 2 JBrowse link 2 177,836,191 178,057,378 RGD:6907045
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6907045
G Rasa2 RAS p21 protein activator 2 JBrowse link 8 104,417,827 104,542,313 RGD:6907045
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:6907045
G Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 JBrowse link 2 21,460,041 21,698,937 RGD:6907045
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:6907045
G Rasgrp2 RAS guanyl releasing protein 2 JBrowse link 1 221,771,238 221,788,765 RGD:6907045
G Rasgrp3 RAS guanyl releasing protein 3 JBrowse link 6 21,072,634 21,171,619 RGD:6907045
G Rasgrp4 RAS guanyl releasing protein 4 JBrowse link 1 88,078,350 88,094,331 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G RGD1564956 similar to calcium binding protein P22 JBrowse link 5 70,747,534 70,749,967 RGD:6907045
G RGD1565395 similar to stathmin 1/oncoprotein 18) JBrowse link 10 83,147,416 83,147,903 RGD:6907045
G RGD1565588 similar to calcium binding protein P22 JBrowse link 4 6,477,461 6,479,158 RGD:6907045
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:6907045
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:6907045
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:6907045
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:6907045
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:6907045
G Rras RAS related JBrowse link 1 101,012,822 101,016,720 RGD:6907045
G Rras2 RAS related 2 JBrowse link 1 178,940,515 179,010,257 RGD:6907045
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1304398
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:6907045
G Stk3 serine/threonine kinase 3 JBrowse link 7 73,617,926 73,883,896 RGD:6907045
G Stk4 serine/threonine kinase 4 JBrowse link 3 160,467,552 160,546,540 RGD:6907045
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6907045
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:6907045
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:6907045
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6907045
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6907045
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580517
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:2298532
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298532
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2293882
RGD:2298531
RGD:5133242
RGD:5133243
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:4143515
RGD:5133242
RGD:5490965
RGD:5490966
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:5133243
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:2293882
c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:2293876
RGD:2293879
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:2293881
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:2293881
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:2293881
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:2314491
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:2293881
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:2293875
RGD:2298561
RGD:2298577
RGD:2298708
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:2293875
RGD:2298561
RGD:2298567
RGD:2298577
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:2293875
RGD:2293879
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:2293875
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:2293875
RGD:2293876
RGD:2298567
RGD:2298577
G Map3k12 mitogen activated protein kinase kinase kinase 12 JBrowse link 7 144,102,275 144,120,306 RGD:2293875
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:2293875
RGD:2293879
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2293875
RGD:2293879
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:2293875
RGD:2293879
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:2293875
G Map3k9 mitogen-activated protein kinase kinase kinase 9 JBrowse link 6 105,455,461 105,518,974 RGD:2293875
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:2293875
RGD:2298561
RGD:2298567
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:2293875
RGD:2298561
RGD:2298577
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:1579811
RGD:2293880
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:2293880
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:2293880
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:2293875
RGD:2298561
RGD:2298577
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:2293876
RGD:2293879
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:11534984
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2296020
Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:1582263
RGD:2298532
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:2298532
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2298532
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298532
RGD:2298794
G Sh2d2a SH2 domain containing 2A JBrowse link 2 187,218,851 187,225,000 RGD:2298532
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:2298532
p38 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1625329
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6484113
G Bnip2 BCL2 interacting protein 2 JBrowse link 8 76,400,333 76,426,307 RGD:7240533
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6484113
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6484113
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6484113
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6484113
G Ccm2 CCM2 scaffolding protein JBrowse link 14 86,812,728 86,859,408 RGD:2293891
RGD:6484113
RGD:7240533
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:7240533
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:7240533
G Dlk1 delta like non-canonical Notch ligand 1 JBrowse link 6 133,576,513 133,583,751 RGD:7240533
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:7240533
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:7240533
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:7240533
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:7240533
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6484113
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6484113
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6484113
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128786
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:2293891
RGD:2298758
RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:2293891
RGD:2298758
RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:6484113
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:7240533
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:7240533
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2293891
RGD:6484113
RGD:7240533
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:6484113
RGD:7240533
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
RGD:7240533
G Map3k6 mitogen-activated protein kinase kinase kinase 6 JBrowse link 5 151,435,679 151,448,329 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:2293891
RGD:2298758
RGD:6484113
RGD:7240533
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:7240533
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:2293891
RGD:6484113
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:2293891
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:2293891
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1580544
RGD:2293891
RGD:6484113
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:2293891
RGD:2302280
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:2315047
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:2315047
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:2315047
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:7240533
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:2293891
RGD:6484113
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:7240533
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:6484113
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:6484113
RGD:7240533
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:6484113
RGD:7240533
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2296020
RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6484113
RGD:7240533
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6484113
the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 1,369,534 1,391,603 RGD:5686410
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1580106
RGD:1626216
RGD:5686410
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:2293881
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:5686410
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:628557
RGD:5686410
G Ksr1 kinase suppressor of ras 1 JBrowse link 10 66,323,704 66,342,469 RGD:2293880
RGD:5686410
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:70317
RGD:1626216
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:729046
RGD:1626216
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:1357969
RGD:2293879
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:724475
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:628468
RGD:1626216
RGD:8553011
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:628468
RGD:1626216
RGD:8553011
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
RGD:8553011
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:5686410
G Pebp1 phosphatidylethanolamine binding protein 1 JBrowse link 12 45,026,948 45,031,148 RGD:2293882
RGD:2302807
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1642529
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642630
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:70317
RGD:1580106
RGD:1626216
RGD:5686410
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:2315047
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:2315047
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:2315047
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:2315047
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1304283
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1643182
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1643230
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580097

Pathway Gene Annotations

Disease Annotations Associated with Genes in the mitogen activated protein kinase signaling pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
22q11 Deletion SyndromeFgf8
46,XY Sex Reversal 6Map3k1
Aberrant Crypt FociFos , Mapk1 , Mapk3 , Myc
Abnormalities, MultipleCacna1c , Cacna1g , Cdc42 , Chuk , Fgfr2 , Fgfr3 , Kras , Mapk1 , Nf1 , Ntf4 , Pdgfrb , Pla2g6
Abortion, SpontaneousFgf7 , Il1b , Tgfb1 , Tgfbr1
Acanthosis NigricansFgfr3
AchondroplasiaFgfr3
Achondroplastic DwarfismFgfr3
Acne VulgarisTnf , Tnfrsf1a
Acneiform EruptionsFgfr2
Acquired Immunodeficiency SyndromeTnf , Tnfrsf1a
AcrocephalosyndactyliaFgfr1 , Fgfr2 , Fgfr3
Acromicric dysplasiaTgfb1
Acute Coronary SyndromeHspa1a , Hspa8 , Tnf
Acute Kidney InjuryDdit3 , Egf , Egfr , Fas , Hspa1a , Hspa8 , Il1a , Il1b , Myc , Tgfb1 , Tnf , Tnfrsf1a , Tp53
Acute Lung InjuryEgfr , Fas , Faslg , Il1b , Ngf , Pak1 , Pla2g2a , Tgfb1 , Tnf
Acute-Phase ReactionDdit3
AdenocarcinomaEgf , Egfr , Erbb2 , Fgf9 , Hspa8 , Il1b , Kras , Myc , Nfkb1 , Tgfb1 , Tnf , Tp53
Adenocarcinoma of EsophagusFas , Tp53
Adenocarcinoma of LungAkt1 , Braf , Egfr , Erbb2 , Fgfr2 , Fgfr3 , Hras , Hspb1 , Kras , Map2k1 , Myc , Nras , Ppp3ca , Raf1 , Rasa1 , Sos1 , Tp53
ADENOCARCINOMA OF STOMACHAkt1 , Braf , Erbb2 , Fgfr1 , Fgfr2 , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Tp53
Adenocarcinoma, Bronchiolo-AlveolarEgfr , Kras , Tp53
Adenocarcinoma, Clear CellDaxx , Tp53
Adenocarcinoma, ColonDaxx , Mapk1 , Mapk3 , Rac1
Adenocarcinoma, ColorectalFos , Jun , Mapk1 , Mapk3 , Mapk8 , Raf1 , Tp53
Adenocarcinoma, FollicularKras
Adenocarcinoma, ProstaticAkt1 , Braf , Erbb2 , Hras , Map2k1 , Tp53
AdenomaCacna1d , Kras , Nf1 , Tp53
Adenoma, ColorectalFos , Jun , Mapk8 , Raf1 , Tnfrsf1a
Adenoma, Liver CellHras , Kras
Adenomatous Polyposis ColiAkt1 , Egfr
Adrenal Gland NeoplasmsCdc42 , Prkaca , Tp53
Adrenal InsufficiencyPla2g2a
Adrenocortical CarcinomaBraf , Daxx , Egfr , Nras , Tp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Aggressive PeriodontitisIl1r2
Aging, PrematureFgf23 , Mapt , Tp53
AgranulocytosisIl1b
AIDS Dementia ComplexIl1b , Pdgfb
AIDS-Associated NephropathyEgf
Aland Island Eye DiseaseCacna1f
AlbuminuriaIl1b , Tnf
AlopeciaBdnf
Alveolar Bone LossTnf
Alveolitis, Extrinsic AllergicIl1a , Il1b , Tnf , Tnfrsf1a
Alzheimer DiseaseAkt1 , Atf2 , Bdnf , Casp3 , Cdc42 , Egf , Egfr , Elk1 , Fas , Fgf1 , Fgfr1 , Hras , Hspa1a , Hspa1b , Hspb1 , Ikbkb , Il1a , Il1b , Mapk10 , Mapk14 , Mapk8 , Mapk9 , Mapt , Ngf , Ntf3 , Ntrk1 , Ntrk2 , Pak1 , Pdgfb , Ptpn5 , Shc1 , Tnf , Tp53 , Tsc2
AmeloblastomaBraf
AmnesiaBdnf , Il1a , Ngf
Amphetamine-Related DisordersAkt1 , Arrb2 , Bdnf , Fos , Map2k5 , Rela
Amyloid NeuropathiesDusp1
AmyloidosisTnf , Tnfrsf1a
Amyotrophic Lateral SclerosisAkt1 , Casp3 , Mapk14 , Pla2g4a , Tnf , Tp53
Amyotrophic Lateral Sclerosis 1Fgf6 , Fos , Jund , Pdgfa , Shc1 , Tnf
AnemiaIl1b , Kras , Tnf , Tnfrsf1a
Anemia, AplasticFas , Faslg , Tgfb1 , Tnf
Anemia, Hypochromic MicrocyticTnf
Anemia, Iron-DeficiencyTnf
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
Anemia, RefractoryTnf
Anemia, Sickle CellTgfb1 , Tnf
AnetodermaTgfb1
AneurysmTgfbr2
Aneurysm, DissectingTgfbr1 , Tgfbr2
Angina, StableTnf
Angina, UnstableAkt1 , Bdnf
AngiomyolipomaTsc2
AnkylosisFgfr2
Anorectal AtresiaFgfr2
AnorexiaIl1a , Il1b , Tnf , Tnfrsf1a
AnoxiaAtf4 , Bdnf , Casp3
AnthracosisIl1a , Il1b , Tnf
Anti-Glomerular Basement Membrane DiseaseDusp1 , Il1b , Mapk14 , Mapk8 , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas , Tnf , Tnfrsf1a
Antley-Bixler Syndrome PhenotypeFgfr2
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISFgfr2
Anxiety DisordersFos , Tnf
Aortic AneurysmTgfbr1 , Tgfbr2
Aortic Aneurysm, AbdominalMapk8
Aortic Aneurysm, Familial Thoracic 1Tgfbr2
Aortic Aneurysm, Familial Thoracic 3Tgfbr2
Aortic Aneurysm, ThoracicFas , Tgfb2 , Tgfbr1 , Tgfbr2
Aortic Valve InsufficiencyEgfr , Tgfb1 , Tgfb2
Aortic Valve StenosisEgfr , Ppp3cb
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Aplasia of Lacrimal and Salivary GlandsFgf10
Arrhythmias, CardiacCacna1c , Cacnb2 , Map2k4
Arrhythmogenic Right Ventricular DysplasiaTgfb3
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Tgfb3
Arsenic PoisoningGadd45b , Hspa1b , Il1a , Il1b , Tnf , Tp53
ArteriosclerosisDusp1 , Faslg , Il1b , Mapk9 , Rela , Tgfb1 , Tgfbr2 , Tnfrsf1a
Arteriovenous FistulaArrb1 , Arrb2 , Fgf2
Arteriovenous MalformationsRasa1
Arthritis, ExperimentalAkt1 , Arrb1 , Arrb2 , Cdc42 , Egfr , Faslg , Fgf8 , Fgfr1 , Ikbkb , Ikbkg , Il1a , Il1b , Nras , Tgfbr2 , Tnf , Tnfrsf1a
Arthritis, InfectiousTnf
Arthritis, JuvenileCd14 , Ddit3 , Dusp1 , Dusp2 , Dusp4 , Egf , Fos , Gadd45a , Il1a , Jun , Kras , Mapk1
Arthritis, PsoriaticTnf
Arthritis, RheumatoidFas , Faslg , Hspb1 , Il1a , Il1b , Pdgfb , Rasgrp1 , Tnf , Tnfrsf1a , Traf6
AsbestosisDdit3 , Tnf
Aspergillosis, Allergic BronchopulmonaryIl1a , Tnf , Tnfrsf1a
AsphyxiaJun
AsthmaBdnf , Cd14 , Chuk , Egfr , Fas , Il1a , Il1b , Ngf , Ntf3 , Ntf4 , Ntrk1 , Pdgfb , Pla2g4a , Tgfb1 , Tnf , Tnfrsf1a
Asthma, OccupationalPla2g4a , Prkca , Tgfb1 , Tnf
AstrocytomaAkt1 , Braf , Fgfr1 , Kras , Map2k3 , Nf1 , Ntrk2 , Tp53
AtaxiaBdnf , Cacna1a , Cacna2d2 , Cacnb4
Atelosteogenesis Type 1Flnb
Atelosteogenesis Type 3Flnb
AtherosclerosisAkt1 , Faslg , Fgf21 , Hspa1a , Hspa1b , Il1b , Ngf , Pdgfrb , Pla2g2a , Tnf
Atrial FibrillationTnf
AtrophyMapk3
Attention Deficit Disorder with HyperactivityBdnf , Ntrk2
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autism Spectrum DisorderBdnf , Dusp14 , Mapk11 , Mapk12 , Mapk3 , Mapk8ip2 , Mef2c , Taok2 , Tsc2
Autistic DisorderBdnf , Cacna1c , Cacna1h , Egf , Hras , Mef2c , Nf1 , Ntf3 , Ntf4 , Ntrk2 , Pla2g4a , Prkcb , Tnf , Tsc2
Autoimmune DiseasesFas , Tgfb2 , Tnfrsf1a
Autoimmune Lymphoproliferative SyndromeFas , Faslg , Nras
Autoimmune Lymphoproliferative Syndrome, Type IAFas
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
BacteremiaMapkapk3
Bacterial InfectionsCasp3
Bacterial KeratitisIl1r1
Balkan NephropathyTp53
Bardet-Biedl SyndromeAkt3
Barrett EsophagusFas , Rela
Bartter Syndrome, Antenatal Type 1Nf1
Basal Ganglia Calcification, Idiopathic, 4Pdgfrb
Basal Ganglia Calcification, Idiopathic, 5Pdgfb
Basal Ganglia DiseasesPdgfb , Pdgfrb
Behcet SyndromeFas , Ikbkg , Il1b , Tgfb1 , Tnf , Tnfrsf1a
Benign Skin NeoplasmsHras
Bent Bone Dysplasia SyndromeFgfr2
BerylliosisTgfb1 , Tnf
Beta-ThalassemiaIl1a , Tnf
Bile Duct NeoplasmsEgfr
Biliary AtresiaCd14
Biliary Tract DiseasesFgf2
Biliary Tract NeoplasmsFaslg , Prkacb
Bipolar DisorderAkt1 , Bdnf , Cacna1c , Cdc42 , Ntrk1 , Ntrk2
bladder carcinomaFgfr3 , Hras
bladder urothelial carcinomaAkt1 , Braf , Erbb2 , Fgfr3 , Hras , Kras , Map2k1 , Nras , Tp53
BLEEDING DISORDER, PLATELET-TYPE, 18Rasgrp2
Blood Platelet DisordersPla2g4a
Body WeightBdnf , Map2k5
Bone DiseasesFgf2 , Tgfbr2
Bone Diseases, DevelopmentalChuk , Fgfr3 , Flnb , Rps6ka3 , Tgfb2 , Tp53
Bone Diseases, EndocrinePdgfa
Bone Marrow NeoplasmsTp53
Bone NeoplasmsTgfbr2
Boomerang DysplasiaFlnb
Brain DeathMap2k4 , Map2k6
Brain DiseasesTsc2
Brain Diseases, MetabolicFas
Brain EdemaTnf
Brain InfarctionFgf2 , Il1b , Pdgfb
Brain InjuriesAkt1 , Bdnf , Casp3 , Cd14 , Dusp5 , Elk1 , Fas , Fgf2 , Fos , Hspa1a , Hspb1 , Il1a , Il1b , Il1r1 , Jun , Pdgfa , Pdgfb , Pdgfra , Pdgfrb , Ppp3ca , Rela , Tnf , Tnfrsf1a
Brain IschemiaAkt1 , Bdnf , Casp3 , Ddit3 , Dusp6 , Fas , Faslg , Fgf1 , Hspa1b , Hspa8 , Il1a , Il1b , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapt , Nfkb1 , Pak1 , Pla2g4a , Prkaca , Prkacb , Prkca , Rela , Tgfb1 , Tnf , Tnfrsf1a , Tp53
Brain NeoplasmsEgfr , Rela , Tp53
Breast AdenocarcinomaAkt1 , Kras , Tp53
Breast NeoplasmsAkt1 , Akt2 , Braf , Casp3 , Cdc25b , Crkl , Ddit3 , Dusp1 , Dusp6 , Egf , Egfr , Erbb2 , Fas , Faslg , Fgf10 , Fgf2 , Fgf3 , Fgf4 , Fgf8 , Fgfr1 , Fgfr2 , Fgfr3 , Fgfr4 , Flna , Fos , Hras , Hspa1b , Ikbkb , Il1b , Jun , Kras , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k7 , Map3k1 , Mapk1 , Mapt , Mecom , Myc , Pak1 , Pak2 , Pdgfa , Pdgfra , Pdgfrb , Pla2g4a , Prkca , Raf1 , Rela , Stmn1 , Tgfb1 , Tnf , Tp53 , Tsc2
Bronchial HyperreactivityCd14 , Il1b , Ngf , Tnf
BronchiectasisIl1b , Tnf
Bronchiectasis with or without Elevated Sweat Chloride 1Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 2Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 3Tnfrsf1a
BronchiolitisIl1b
Bronchiolitis, ViralCd14 , Tnf
Bronchopulmonary DysplasiaIl1b , Tnf
Brugada SyndromeCacna1c , Cacna2d1 , Cacnb2
Brugada Syndrome 3Cacna1c
Brugada Syndrome 4Cacnb2
Bulimia NervosaBdnf
Burkitt LymphomaMyc
BurnsCasp3 , Cd14 , Fgfr1 , Il1a , Il1b , Ngf , Pla2g4a , Tnf
Burns, ChemicalFgfr2 , Il1a , Il1b , Il1r1
CachexiaIl1b , Tgfb1 , Tnf , Tnfrsf1a
Cafe au lait Spots, MultipleNf1 , Sos1
Cafe-au-Lait SpotsNf1
CakutHspa1b
CalcinosisCasp3 , Erbb2 , Fgf23 , Il1b , Pdgfb , Pdgfrb , Tgfb1
Camurati-Engelmann SyndromeTgfb1
Capillary Malformation-Arteriovenous MalformationRasa1
CarcinogenesisBraf , Erbb2 , Kras
CarcinomaCdc42 , Dusp6 , Egfr , Fgfr3 , Hras , Kras , Myc , Pdgfa , Rasa1 , Rasgrf2 , Stmn1 , Tgfb1 , Tgfbr2 , Tp53
Carcinoma in SituAkt1 , Pdgfra
Carcinoma, Adenoid CysticFgf16 , Fgfr4 , Hras , Map2k2 , Tp53
Carcinoma, Basal CellErbb2 , Rasa1 , Tp53
Carcinoma, Ductal, BreastAkt1 , Atf4 , Cacna1c , Cacna1h , Crkl , Map2k4
Carcinoma, EmbryonalFgf8
Carcinoma, EndometrioidAkt1 , Daxx , Egfr , Erbb2 , Fgfr2 , Kras , Pdgfra , Pdgfrb
Carcinoma, HepatocellularAkt1 , Akt2 , Braf , Egf , Egfr , Fgf19 , Fgf3 , Fgf4 , Fgfr1 , Fos , Hras , Hspb1 , Il1b , Jun , Kras , Myc , Nras , Pdgfb , Rac1 , Rps6ka3 , Shc1 , Srf , Tgfb1 , Tgfbr2 , Tnf , Tp53
Carcinoma, Intraductal, NoninfiltratingErbb2 , Pak2 , Prkca , Rela , Tp53
Carcinoma, Islet CellDaxx
Carcinoma, Large CellPrkca
Carcinoma, LobularErbb2 , Faslg
Carcinoma, Merkel CellMyc
Carcinoma, Non-Small-Cell LungAkt1 , Akt2 , Braf , Dusp3 , Egfr , Erbb2 , Faslg , Fgf9 , Fgfr1 , Hras , Il1a , Il1b , Kras , Map2k1 , Myc , Nras , Raf1 , Rela , Tnf , Tnfrsf1a , Tp53
Carcinoma, Pancreatic DuctalEgf , Faslg , Fgf2 , Hspa1a , Hspa1b , Kras , Tgfb1 , Tgfbr2 , Tsc2
Carcinoma, Renal CellAkt1 , Casp3 , Egfr , Erbb2 , Fas , Faslg , Fgf2 , Fgfr1 , Hspb1 , Jun , Kras , Map2k1 , Myc , Nras , Pak1 , Pdgfra , Pdgfrb , Rela , Tnf , Tnfrsf1a , Tp53 , Tsc2
Carcinoma, Small CellTnf , Tp53
Carcinoma, Squamous CellAkt1 , Dusp1 , Egfr , Fas , Fgf7 , Fgfr1 , Fgfr2 , Hras , Hspa8 , Hspb1 , Kras , Mapk1 , Mapk3 , Myc , Rasa1 , Tgfb1 , Tnfrsf1a , Tp53 , Tsc2
Carcinoma, Squamous Cell of Head and NeckAkt1 , Braf , Egfr , Erbb2 , Fgfr3 , Hras , Map2k1 , Map2k2 , Mapk1 , Rac1 , Rasgrp3 , Tp53
Carcinoma, Transitional CellAkt1 , Braf , Casp3 , Daxx , Egfr , Erbb2 , Fas , Faslg , Fgf1 , Fgf2 , Fgfr1 , Fgfr2 , Fgfr3 , Hras , Kras , Map2k1 , Mapk1 , Nras , Pak1 , Pla2g4a , Tnf , Tp53
CarcinosarcomaTgfb1
Cardiac Complexes, PrematureCacna1c , Cacnb2
Cardiac Conduction Defect, NonspecificCacnb2
Cardiac FibrosisPak1 , Tgfb1
Cardiac Valvular Dysplasia, X-LinkedFlna
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Egfr , Fgf2 , Fgf21 , Il1b , Map2k5 , Map2k6 , Mapk1 , Mapk8 , Myc , Pak1 , Pdgfrb , Ppp3ca , Prkca , Prkcb , Rac1 , Raf1 , Rela , Shc1 , Srf , Tgfb1 , Tnf
CardiomyopathiesAkt1 , Fas , Faslg , Flnc , Il1a , Il1b , Kras , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Srf , Tnf , Tp53
Cardiomyopathy, DilatedCacnb2 , Egfr , Erbb2 , Fas , Faslg , Kras , Map2k5 , Mef2c , Nfatc4 , Ppp3r1 , Prkca , Prkcb , Rac1 , Raf1 , Srf , Tnf
Cardiomyopathy, Dilated, 1GNf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 26Flnc
Cardiomyopathy, Familial Hypertrophic, 4Braf
Cardiomyopathy, Familial Hypertrophic, 9Nf1
CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 5Flnc
Cardiomyopathy, HypertrophicCasp3 , Hspb1 , Kras , Myc , Prkaca , Raf1 , Sos1 , Tgfb1 , Tgfb3 , Tp53
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1 , Sos1
Cardiomyopathy, RestrictiveCacna1c , Map2k3 , Map2k6 , Mapk14
Cardiovascular AbnormalitiesFgf8 , Map2k1 , Srf
Cardiovascular DiseasesHspa1a
Cardiovirus InfectionsTnf
Carotid Artery DiseasesCd14 , Faslg , Mras , Tgfb1 , Tp53
Carotid Artery InjuriesDusp1 , Myc
Carotid AtherosclerosisFgf21
Carotid StenosisFaslg
Cartilage DiseasesFgf14
CataractFas , Fgf2 , Map2k1 , Tp53
CATSHL SyndromeFgfr3
Cecal NeoplasmsKras , Tp53
Celiac DiseaseCd14
Cell Transformation, NeoplasticEgf , Fos , Hras , Jun , Kras , Mapk8 , Myc , Nfkb1 , Rac1 , Rela , Tgfb1 , Tp53
Central Nervous System NeoplasmsTp53
Cerebellar AtaxiaCacna1a
Cerebral HemorrhageBdnf , Casp3 , Cd14 , Nfkb1 , Nfkb2 , Rela
Cerebral InfarctionTnf
Ceroid Lipofuscinosis, Neuronal 8Nf1
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
cervical cancerFgfr3 , Tp53
Cervical Intraepithelial NeoplasiaFaslg , Rela
Charcot-Marie-Tooth DiseaseHspb1 , Ntrk2
Charcot-Marie-Tooth Disease, Type 2FHspb1
Chemotherapy-Induced Febrile NeutropeniaTp53
Chest TraumaFas
Chlamydia InfectionsTnf
ChloracneEgfr , Gadd45a
CholangiocarcinomaEgfr , Erbb2 , Faslg , Fgf2 , Fgfr2 , Kras , Prkaca , Prkacb , Tgfb1 , Tgfbr2 , Tp53
CholangitisTgfb2
CholecystolithiasisPla2g2a
CholestasisCd14 , Il1a , Mapk13 , Mapk14 , Pdgfb , Rela , Tnf
Cholestasis, ExtrahepaticPdgfrb
CholesteatomaIl1a , Il1b
Cholesteatoma, Middle EarFgf2 , Il1a , Il1r1 , Rela , Tnf , Tp53
ChondrosarcomaFgfr3
Chondrosarcoma, MesenchymalIl1a , Pdgfra
ChoreaCacna2d2
ChorioamnionitisFas , Il1a , Tgfb1 , Tnf
ChoriocarcinomaFgf8 , Pdgfb , Pdgfrb
Choroid Plexus CarcinomaTp53
Choroidal NeovascularizationFgf2 , Ikbkb
Chromosome 17 DeletionTp53
Chromosome 17q12 Deletion SyndromeDusp14
Chromosome BreakageMyc
Chronic Allograft DysfunctionTnf
Chronic Allograft NephropathyPdgfa , Pdgfb , Pdgfra , Pdgfrb
Chronic Cerebral HypoperfusionMapk14
Chronic Lymphoid LeukemiaBraf , Hras , Kras , Myc , Nras , Tp53
Chronic Myeloproliferative DisorderPdgfrb
Chronic PainBdnf , Ntrk2
Chronic PeriodontitisRac2
Chronic UveitisFas
Clear-Cell Metastatic Renal Cell CarcinomaMyc
Cleft LipFgf1 , Fgf10 , Fgf2 , Fgf3 , Fgf7 , Fgf8 , Fgf9 , Fgfr1 , Fgfr2 , Fgfr3 , Myc
Cleft PalateChuk , Egf , Fgf10 , Fgf2 , Fgf3 , Fgf7 , Fgf8 , Fgf9 , Fgfr1 , Fgfr2 , Fgfr3 , Flna , Flnb , Myc , Pdgfra , Tgfb1 , Tgfb2 , Tgfb3
ClonorchiasisFas , Faslg
ClubfootFlnb
Cocaine-Related DisordersBdnf , Fgf2 , Fos , Jund , Mapk1 , Mapk3 , Ngf , Ntrk2 , Rps6ka5
Cocoon SyndromeChuk
Coffin-Lowry SyndromeRps6ka3
Cognition DisordersBdnf , Fgf14 , Mapk14 , Mapt
ColitisArrb1 , Bdnf , Chuk , Dusp1 , Ikbkb , Il1b , Ntrk1 , Ntrk2 , Pla2g2a , Rela , Tnf
Colitis, ExperimentalFas , Pdgfra , Pdgfrb , Tnf , Tnfrsf1a
Colitis, UlcerativeTp53
colon adenomaRac1
colon cancerAkt1 , Braf , Fgfr3 , Nras , Pla2g2a , Tp53
Colonic NeoplasmsAkt1 , Akt2 , Akt3 , Braf , Cacna2d1 , Casp3 , Crkl , Egfr , Erbb2 , Fas , Fgfr3 , Fos , Hspa2 , Hspb1 , Ikbkb , Il1b , Jun , Kras , Map2k3 , Map2k6 , Mapk8 , Mapk9 , Mecom , Myc , Nfkb1 , Nras , Pdgfrb , Pla2g2a , Rela , Tgfbr2 , Tnf , Tnfrsf1a , Tp53
Color Vision DefectsBdnf
colorectal cancerAkt1 , Braf , Fgfr3 , Nras , Rac1 , Tp53
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Egfr , Erbb2 , Fgfr3 , Flnc , Fos , Hras , Hspa8 , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pla2g2a , Prkcb , Raf1 , Tgfb1 , Tgfbr1 , Tnf , Tp53
Colorectal Neoplasms, Hereditary NonpolyposisTgfbr1 , Tgfbr2
Common ColdIl1a , Il1b
Common Variable ImmunodeficiencyNfkb2
Cone Dystrophy 3Cacna2d4
Cone-Rod Dystrophy, X-Linked, 3Cacna1f
Congenital Central Hypoventilation SyndromeBdnf
Congenital Idiopathic Intestinal PseudoobstructionFlna
Congenital Myasthenic Syndrome IbCacna1c
Conjunctivitis, AllergicIl1b , Pla2g2a , Tgfb1
Conjunctivitis, ChronicFas
Contrast-Induced NephropathyIl1b
Copper-Overload CirrhosisCasp3 , Tgfb1
Corneal EdemaIl1a
Corneal NeovascularizationFas , Fgf2
Corneal UlcerNgf , Tnf
Coronary Artery DiseaseAkt1 , Cd14 , Fgf2 , Il1b , Mras , Ngf , Tgfb1 , Tnf , Tnfrsf1a , Traf6
Coronary DiseaseCd14 , Fgf2 , Hspa1a , Il1b
Coronary OcclusionHspa1a
Coronary RestenosisMapk1 , Myc , Tnf , Tp53
Costello SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
CoughTnf
Coxsackievirus InfectionsTnf
Craniocerebral TraumaIl1a
Cranioectodermal dysplasiaTgfb3
Craniofacial AbnormalitiesEgfr , Fgf3 , Fgf8 , Fgfr1 , Fgfr2 , Pdgfra , Tgfb2 , Tgfbr2 , Tp53
Craniofacial DysostosisFgfr2
CraniopharyngiomaBraf , Pdgfra
CraniosynostosesFgfr1 , Fgfr2 , Fgfr3 , Flna
Creutzfeldt-Jakob SyndromeIl1a
Crohn DiseaseHspa1l , Tnf , Tnfrsf1a
Crouzon Syndrome with Acanthosis NigricansFgfr3
CryoglobulinemiaTnf
Cryptogenic Organizing PneumoniaTnfrsf1a
CryptorchidismCasp3 , Rela
Currarino TriadMap3k13
Cutis Gyrata Syndrome of Beare And StevensonFgfr2
CyanosisTgfb2
Cystadenocarcinoma, SerousTp53
Cystadenoma, MucinousDaxx
Cystadenoma, SerousDaxx
Cystic FibrosisCd14 , Fas , Faslg , Hspa1a , Il1a , Il1b , Tgfb1 , Tnf , Tnfrsf1a
CystitisBdnf , Il1b , Ngf , Rela , Tnf
Cystitis, InterstitialNgf , Tnf
Cytomegalovirus InfectionsTnf
Cytomegalovirus RetinitisTnf , Tnfrsf1a
DeafnessBdnf , Cacna1d
Deafness, Congenital, with Inner Ear Agenesis, Microtia, and MicrodontiaFgf3
Death, SuddenMap2k5
Death, Sudden, CardiacCacna1c
DementiaEgfr , Mapt
Dementia, VascularBdnf , Fgfr1 , Hspa1a , Il1b , Tp53
Demyelinating DiseasesFgf2 , Fgfr1 , Fgfr3 , Myc , Tnf , Tp53
Depressive DisorderBdnf , Fgf2 , Fgfr1 , Il1b , Jun , Ngf , Ntrk2 , Pla2g2a
Depressive Disorder, MajorBdnf , Dusp1 , Hspa1a , Hspa1l , Ntrk2
DermatitisFgf2 , Ikbkb , Pla2g4a , Tnf
Dermatitis HerpetiformisTnf
Dermatitis, Allergic ContactIl1a , Tnf
Dermatitis, AtopicBdnf , Il1b , Mapk8 , Ngf , Ntrk1 , Tgfb1 , Tnf
Dermatitis, ContactDdit3 , Dusp1 , Hspb1
DermatofibrosarcomaPdgfb
DermatomyositisFas , Il1a , Il1b , Tnf
Developmental DisabilitiesAkt3 , Cacna1a , Ntrk2 , Rps6ka3
Diabetes Insipidus, NephrogenicPrkca
Diabetes MellitusRac1
Diabetes Mellitus, ExperimentalAkt1 , Bdnf , Casp3 , Dusp1 , Egfr , Fas , Faslg , Fgf2 , Fgf21 , Hras , Ikbkb , Il1a , Il1b , Map2k3 , Map2k6 , Mapk1 , Mapk3 , Mef2c , Myc , Nfkb2 , Ngf , Ntrk1 , Pdgfb , Pdgfrb , Prkca , Prkcb , Rap1b , Rasgrf1 , Rela , Tgfb1 , Tgfb2 , Tnf , Tnfrsf1a , Tp53 , Tsc2
Diabetes Mellitus, Type 1Casp3 , Cd14 , Ddit3 , Dusp1 , Egfr , Fas , Faslg , Fgf21 , Il1a , Il1b , Il1r1 , Tgfb1 , Tnf
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bdnf , Casp3 , Egfr , Fas , Faslg , Fgf2 , Fgf21 , Fgfr1 , Hspa1b , Ikbkb , Il1b , Mapk8ip1 , Nfkb1 , Prkcb , Rela , Tgfb1 , Tgfbr2 , Tnf , Tnfrsf1a
Diabetes, GestationalFgf2
Diabetic AngiopathiesCasp3 , Fas , Faslg , Rela , Tnf
Diabetic CardiomyopathiesErbb2 , Tnf
Diabetic EncephalopathiesDusp1 , Ngf
Diabetic FootHspa1b
Diabetic NephropathiesBdnf , Casp3 , Egf , Fas , Faslg , Fgf2 , Fgf21 , Fgf23 , Hspa1a , Hspa1b , Hspa8 , Hspb1 , Il1b , Mapk1 , Mapk14 , Ntrk2 , Pdgfa , Pdgfb , Pdgfrb , Prkcb , Rela , Tgfb1 , Tgfbr2 , Tnf , Tnfrsf1a , Tp53
Diabetic NeuropathiesBdnf , Casp3 , Fgf2 , Il1b , Mapk14 , Ngf , Ntf3 , Ntrk1 , Tgfb1 , Tgfb2 , Tgfb3 , Tnf
Diabetic RetinopathyBdnf , Casp3 , Egfr , Fgf2 , Hras , Il1a , Il1b , Ngf , Tnf
Diaphyseal Dysplasia 1, ProgressiveTgfb1
DiarrheaCd14 , Il1a
DiGeorge SyndromeCrkl , Fgf8
Dilatation, PathologicTgfb1
Disease Models, AnimalAkt1 , Erbb2 , Fas , Fos , Il1b , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mapt , Prkcg , Tnf , Tp53
Disease ProgressionAtf2 , Egf , Egfr , Erbb2 , Fgf2 , Hras , Myc
Disseminated Intravascular CoagulationTnf
Down SyndromeNtf3
Drug EruptionsBdnf
Drug HypersensitivityFaslg , Hspa1a , Hspa1l , Tnf
Drug Hypersensitivity SyndromeHspa1l , Il1b
Drug-induced agranulocytosisIl1b
Drug-Induced Immune ThrombocytopeniaIl1a , Il1b
Drug-Induced Liver InjuryCdc25b , Fas , Gadd45a , Hspa8 , Il1a , Il1b , Il1r2 , Tnf
Drug-induced NeutropeniaIl1a , Tp53
Drug-Related Side Effects and Adverse ReactionsTp53
Dry Eye SyndromesIl1b , Tgfb1 , Tnf
Duodenal UlcerPla2g4a , Tgfb1
DwarfismFgfr3
DysarthriaCacna1a
Dysembryoplastic Neuroepithelial TumorBraf
DysgerminomaFgfr2
Dyskeratosis Congenita, Autosomal RecessiveTp53
Dyskinesia, Drug-InducedCacna1d , Rasgrf1 , Rela
DyskinesiasRasgrf1
Dystonia 12Pla2g6
Dystonia 23Cacna1b
Dystonia-Parkinsonism, Adult-OnsetPla2g6
Eales DiseaseIl1b , Tnf
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EctrodactylyMap3k20
EczemaCd14
EdemaCasp3 , Il1b , Map2k6 , Tnf
Ehlers-Danlos SyndromeTgfb1
EmphysemaTnf , Tp53
EncephalitisIl1b , Rela , Tnf
Encephalocraniocutaneous LipomatosisFgfr1
EncephalomyelitisTnf
Encephalomyelitis, Autoimmune, ExperimentalBdnf , Cacna1b , Casp3 , Dusp10 , Faslg , Fgf2 , Mapt , Ngf , Ntrk1 , Pdgfb , Pdgfra , Pdgfrb , Tgfb1 , Tgfb2 , Tnf
End Stage Liver DiseaseTnfrsf1a
Endodermal Sinus TumorFgf8
Endometrial HyperplasiaCdc25b , Kras
Endometrial NeoplasmsCdc25b , Erbb2 , Fgf1 , Fgf2 , Fgf7 , Fgfr2 , Jun , Kras , Map3k4 , Myc , Prkca , Tnfrsf1a , Tp53
EndometriosisDusp1 , Egfr , Fgfr2 , Fos , Il1r1 , Kras , Nr4a1 , Ntrk1 , Pla2g2a , Rasgrp1 , Tgfb2 , Tnf
EndometritisIl1a
Endomyocardial FibrosisTgfb1
EndophthalmitisFas , Il1b , Tnf
EndotoxemiaAtf2 , Casp3 , Cd14 , Fas , Il1a , Il1b , Mapk14 , Tnf
EntamoebiasisIl1b
EnterocolitisIl1a , Il1b
Enterocolitis, NecrotizingCd14 , Egf , Ikbkg , Il1b , Tnf
Enterocolitis, NeutropenicIl1b
Enterovirus InfectionsTnfrsf1a
EosinophiliaPdgfra
Eosinophilic EsophagitisTgfb1
Epidermal NevusFgfr3 , Hras , Kras , Nras
Epilepsies, PartialBdnf , Cacna1h
EpilepsyAkt1 , Bdnf , Cacna1c , Flna , Fos , Mef2c , Ntrk2 , Tsc2
Epilepsy, AbsenceCacna1a , Cacna1h , Cacna2d2 , Cacng3
Epilepsy, GeneralizedCacna1a , Cacnb4 , Mapk10
Epilepsy, Idiopathic GeneralizedCacnb4
Epilepsy, Temporal LobeCacna1a , Cdc42 , Ntrk2 , Rasgrf1
Epilepsy, Tonic-ClonicBdnf , Fgf2 , Ngf , Ntf3
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 42Cacna1a
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 47Fgf12
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Episodic AtaxiaCacnb4
Episodic Ataxia with NystagmusCacna1a
Episodic Ataxia, Type 5Cacnb4
Erectile DysfunctionAkt1 , Casp3 , Fgf2 , Tgfb1 , Tnf
Erythema NodosumTnf
Escherichia Coli InfectionsNtrk2
Esophageal NeoplasmsEgfr , Erbb2 , Fas , Faslg , Fgfr2 , Hras , Kras , Map3k3 , Myc , Tgfbr2 , Tp53
Esophageal Squamous Cell CarcinomaEgfr , Tp53
EsophagitisTnf
Esophagitis, PepticEgfr , Tnf
Essential TremorMapt
Exfoliation SyndromeCacna1a
Experimental SeizuresRasgrf1
Eye AbnormalitiesTgfb2 , Tgfbr2
Eye BurnsIl1b
Eye DiseasesTnf
Eye InjuriesFgf2
Eye Injuries, PenetratingFgf2
Fabry DiseaseIl1a
Facial Nerve InjuriesAtf2
Familial Duodenal AtresiaFgfr2
Familial Mediterranean FeverIl1b , Nf1 , Tnfrsf1a
Familial Medullary Thyroid CarcinomaNtrk1
Fanconi AnemiaTnf
Farmer's LungTnf
FatigueTgfbr2
Fatty LiverFgf21 , Il1b , Mapk8 , Myc , Nfkb1 , Rela , Shc1 , Tnf
Femoral FracturesFgf2 , Fgfr1 , Il1a , Nf1
Fetal DeathPdgfra
Fetal DiseasesChuk , Prkcb
Fetal Growth RetardationCasp3 , Dusp1 , Dusp5 , Elk1 , Fas , Faslg , Il1a , Pdgfa , Pdgfb
FeverHspb1 , Il1a , Il1b , Pla2g4a , Tnf , Tnfrsf1a
Fibromatosis, AggressiveTnf
Fibromatosis, Congenital GeneralizedPdgfrb
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosarcomaCdc42 , Nf1 , Tnfrsf1a
FibrosisAkt1 , Il1b , Map2k7 , Pdgfb , Tgfb1 , Tnf
Fibrous Dysplasia of BoneFos
Filaminopathy, Autosomal DominantFlnb , Flnc
Fleck Retina, Familial BenignPla2g5
Focal Cortical Dysplasia of TaylorTsc2
Foot Deformities, CongenitalFgfr1
Forney Robinson Pascoe SyndromeMap3k7
Fractures, BoneFgf2 , Tgfbr2
Frontometaphyseal DysplasiaFlna
Frontometaphyseal Dysplasia 2Map3k7
Frontotemporal DementiaMapt , Mef2c
Frontotemporal Lobar DegenerationBdnf
GalactosemiasDdit3
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Faslg , Fgf2 , Il1b , Kras , Tgfb1 , Tp53
GastritisTnf
Gastritis, AtrophicIl1b
Gastroesophageal RefluxPla2g2a
Gastrointestinal NeoplasmsErbb2
Gastrointestinal Stromal TumorsBraf , Kras , Pdgfra
Gaucher DiseaseTnf
Genetic Diseases, InbornCacna1a , Cacna1c , Cacna1e , Cacna1g , Cdc42 , Fgfr2 , Fgfr3 , Mapk1 , Nf1 , Ntf4 , Ntrk1 , Pdgfrb , Pla2g6
Genetic Predisposition to DiseaseEgf , Il1b
GerminomaBraf
Giant Pigmented Hairy NevusHras , Nras
Gingival HyperplasiaFgf7 , Pdgfb
GlaucomaAtf2 , Bdnf , Fas , Ngf , Ntrk1 , Ntrk2 , Tgfb2 , Tnf
Glaucoma 1, Open Angle, ONtf4
Glaucoma, Open-AngleTnf
Glaucoma, Primary Open AngleBdnf , Tnf , Tp53
GlioblastomaAkt1 , Braf , Dusp6 , Egf , Egfr , Erbb2 , Fgfr1 , Hras , Il1b , Map2k3 , Myc , Nf1 , Nras , Pdgfb , Tp53
GliomaAkt2 , Braf , Egfr , Erbb2 , Fas , Fgf2 , Fgfr1 , Nf1 , Ntrk1 , Ntrk2 , Raf1 , Stmn1 , Tnf , Tp53
GliosisBdnf , Fgf2 , Mapk1 , Mapk3 , Mapt
GlomerulonephritisFas , Fos , Il1a , Il1b , Il1r1 , Jund , Mapk1 , Ngf , Pdgfb , Tnf , Tnfrsf1a
Glomerulonephritis, CrescenticIl1b
Glomerulonephritis, IGACd14 , Il1a , Il1b , Ngf , Tgfb1 , Tnf , Tnfrsf1a
Glomerulonephritis, MembranoproliferativeIl1b , Tgfbr2
Glomerulonephritis, MembranousIl1b
GlomerulosclerosisIl1b
Glomerulosclerosis, Focal SegmentalHspb1 , Il1b , Tgfb1 , Tnf , Tnfrsf1a
Glucose IntoleranceDusp1
Glucosephosphate Dehydrogenase DeficiencyIkbkg
GoutCd14 , Il1b
Graft vs Host DiseaseFas , Faslg , Hspa1a , Hspa1b , Hspa8 , Il1a , Pdgfb , Tp53
Gram-Negative Bacterial InfectionsIl1b
Graves DiseaseFas , Il1b , Tnf , Tp53
Graves OphthalmopathyIl1a , Tnf
HamartomaTsc2
Hamartoma Syndrome, MultipleAkt1 , Egfr , Fgfr2
Hashimoto DiseaseFas
Head and Neck NeoplasmsEgfr , Fgfr2 , Mapk1 , Mapk3 , Tp53
Head Injuries, PenetratingFgfr1 , Pdgfb
Hearing LossBdnf , Ntf3 , Tnf
Hearing Loss, ConductiveFlna
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedBdnf , Hspa1a , Hspa1b , Hspa1l , Taok1 , Tnf
Hearing Loss, SensorineuralBdnf , Fgf3 , Ngf , Prkcb , Tnf
Hearing Loss, SuddenHspa1a , Hspa1b , Hspa1l , Tnf
Heart ArrestAkt1 , Cacna2d1 , Cacnb2 , Tnf
Heart Defects, CongenitalTgfb2
Heart DiseasesMapk14 , Rac2 , Tgfb1
Heart FailureArrb1 , Erbb2 , Fas , Fos , Hspb1 , Il1b , Map2k7 , Prkaca , Prkca , Prkcb , Rac1 , Srf , Tnf , Tnfrsf1a , Tp53
Heart Failure, SystolicHspa1a
Heart InjuriesIl1b
Heart Septal Defects, VentricularBraf , Fos , Tgfb3
Heart Valve DiseasesCasp3 , Il1b
Heat Stress DisordersHspa1a
Heat StrokeFos , Il1a , Il1b , Jun , Nfkb1 , Nfkb2 , Rela , Tnf
Heavy Metal ToxicityDaxx
HELLP SyndromeErbb2