TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY (PW:0000233)

View Ontology Report

Description

Tumor necrosis factor (Tnf or Tnfa) signaling pathway plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis through the activation of several downstream signaling cascades. Tumor necrosis factor and its receptors Tnfrsf1a and Tnfrsf1b (Tnfr1 and Tnfr2) belong to the tumor necrosis superfamilies of ligands and receptors of which 19 and 29 members have been so far identified in humans, respectively. Tnf signaling occurs primarily via Tnfrsf1a receptor (Tnf-R1), ubiquit

Pathway Diagram:

Elsevier Inc. Ripk1 K63-ubiquitin M1-Ubiquitin Tradd M1-ubiquitination K63-ubiquitin ---- Tab3 K63-ubiquitin ---- Tab2 Cyld Casp8 ---- Fadd Fadd Casp8 --+> extrinsic apoptotic pathway extrinsic apoptotic pathway TRAF5 Traf2 Birc2 ---> Ripk1 Birc3 ---- Traf2 Birc3 Ripk1 --+> Map3k7 Birc3 ---- LUBAC complex Bag4 Fadd ---- Tradd Tnfrsf1a ---- Tradd Tnfrsf1a Adam17 ---> Tnf Tnf ---- Tnfrsf1a Tnf Bag4 ---| Tnfrsf1a Tradd ---- TRAF5 Tradd ---- Traf2 Ripk1 ---- Tradd Birc2 Birc2 ---- LUBAC complex LUBAC complex ---- TRAF5 LUBAC complex ---- Tradd LUBAC complex ---- Traf2 A20 ubiquitin-editing complex ---| K63-polyubiquitination Adam17 nuclear factor kappa B signaling pathway Map3k7 --+> nuclear factor kappa B signaling pathway p38 MAPK signaling pathway Map3k7 Map3k7 ---- Tab1 LUBAC complex ---> Ripk1 Birc3 ---> Ripk1 Map3k7 --+> p38 MAPK signaling pathway c-Jun N-terminal kinases MAPK signaling pathway Map3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway Tab1 Tab2 Tab3 Casp8 Map3k7 ---- Tab3 Map3k7 ---- Tab2 A20 ubiquitin-editing complex LUBAC complex K63-polyubiquitination Cyld ---| Map3k7 Cyld ---| K63-polyubiquitination
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Genes in Pathway:

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tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:2292150
RGD:6484113
G Bag4 BCL2-associated athanogene 4 JBrowse link 16 71,057,709 71,075,874 RGD:2292150
RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
RGD:7800730
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6484113
RGD:7800730
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6484113
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:2292150
RGD:6484113
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:6484113
RGD:7800734
RGD:7800735
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:2292150
RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:2292150
RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:2292150
RGD:6484113
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:7800734
RGD:7800735
G Madd MAP-kinase activating death domain JBrowse link 3 79,960,301 80,003,023 RGD:6484113
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6484113
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6484113
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490225
RGD:6484113
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 JBrowse link 1 221,710,622 221,726,274 RGD:6484113
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 JBrowse link 6 3,276,732 3,444,519 RGD:6484113
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 9 46,657,444 46,782,545 RGD:6484113
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 JBrowse link 6 92,136,242 92,229,578 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nrk Nik related kinase JBrowse link X
X
109,940,439
110,065,199
110,036,361
110,089,124
RGD:6484113
G Nsmaf neutral sphingomyelinase activation associated factor JBrowse link 5 19,499,111 19,560,308 RGD:6484113
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:6484113
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:7800730
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:2292150
RGD:6484113
RGD:7800730
G Rnf11 ring finger protein 11 JBrowse link 5 129,296,271 129,298,513 RGD:7800734
RGD:7800735
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:7800730
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7800730
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:6484113
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490225
RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490225
RGD:6484113
G Tab3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490225
G Tax1bp1 Tax1 binding protein 1 JBrowse link 4 82,776,720 82,832,586 RGD:7800734
RGD:7800735
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580210
RGD:2292150
RGD:6484113
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:7800734
RGD:7800735
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:2292150
RGD:5130945
RGD:6484113
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:2292150
RGD:6484113
G Tnik TRAF2 and NCK interacting kinase JBrowse link 2 113,984,599 114,391,805 RGD:6484113
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:2292150
RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2292150
RGD:5130945
RGD:6484113
RGD:7800730
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexA10 ubiqutin-editing complexdeubiquitinase, K48-ubiquitin
ComplexLUBAC complexM1-ubiquitin

Pathway Gene Annotations

Disease Annotations Associated with Genes in the tumor necrosis factor mediated signaling pathway
Disease TermsGene Symbols
46,XY Sex Reversal 6Map3k1
Abnormalities, MultipleChuk
Acne VulgarisTnf , Tnfrsf1a , Tnfrsf1b
Acquired Immunodeficiency SyndromeTnf , Tnfrsf1a , Tnfrsf1b
Acute Coronary SyndromeTnf
Acute Kidney InjuryTnf , Tnfrsf1a , Tnfrsf1b
Acute Lung InjuryCav1 , Fadd , Tnf , Txn1
AdenocarcinomaCasp8 , Nfkb1 , Tnf
Adenoma, ColorectalTnfrsf1a
AlbuminuriaTnf
Alveolar Bone LossTnf
Alveolitis, Extrinsic AllergicTnf , Tnfrsf1a , Tnfrsf1b
Alzheimer DiseaseIkbkb , Tnf
Amphetamine-Related DisordersRela
AmyloidosisTnf , Tnfrsf1a
Amyotrophic Lateral SclerosisMap3k5 , Sqstm1 , Tnf
Amyotrophic Lateral Sclerosis 1Tnf
AnemiaTnf , Tnfrsf1a
Anemia, AplasticTnf
Anemia, Hypochromic MicrocyticTnf
Anemia, Iron-DeficiencyTnf
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
Anemia, RefractoryTnf
Anemia, Sickle CellTnf
Angina, StableTnf
Angina, UnstableTxn1
AngiomyolipomaStat1
AnorexiaTnf , Tnfrsf1a
AnthracosisTnf
Anti-Glomerular Basement Membrane DiseaseTnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTnf , Tnfrsf1a , Tnfrsf1b
Anxiety DisordersTnf
Aortic Aneurysm, AbdominalCav1
Aortic Aneurysm, ThoracicAdam17
Arsenic PoisoningTnf , Tnik
Arterial InjuryMap3k5
Arterial Occlusive DiseasesTxn1
ArteriosclerosisRela , Tnfrsf1a
Arthritis, ExperimentalIkbkb , Ikbkg , Map3k5 , Stat1 , Tnf , Tnfrsf1a , Tnfrsf1b
Arthritis, InfectiousTnf
Arthritis, JuvenileTnik
Arthritis, PsoriaticTnf
Arthritis, RheumatoidStat1 , Tnf , Tnfaip3 , Tnfrsf1a
AsbestosisTnf
Aspergillosis, Allergic BronchopulmonaryTnf , Tnfrsf1a
AsthmaChuk , Tnf , Tnfrsf1a
Asthma, OccupationalTnf
AstrocytomaMap2k3
AtherosclerosisCav1 , Tnf
Atrial FibrillationCav1 , Tnf
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autistic DisorderTnf , Tnfrsf1b
Autoimmune Disease, Multisystem, with Facial DysmorphismItch
Autoimmune DiseasesCasp8 , Tnfaip3 , Tnfrsf1a
Autoimmune Lymphoproliferative SyndromeCasp8
AUTOINFLAMMATORY SYNDROME, FAMILIAL, BEHCET-LIKETnfaip3
Bacterial InfectionsCasp8
Barrett EsophagusRela
Behcet SyndromeIkbkg , Tnf , Tnfrsf1a
BerylliosisTnf
Beta-ThalassemiaTnf
BlisterAdam17
Bone Diseases, DevelopmentalChuk
Brain EdemaTnf
Brain InjuriesCasp8 , Rela , Stat1 , Tnf , Tnfrsf1a
Brain IschemiaCav1 , Nfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Brain NeoplasmsRela
Breast NeoplasmsBirc2 , Casp8 , Cav1 , Ikbkb , Map2k3 , Map2k7 , Map3k1 , Prkci , Rela , Stat1 , Tnf
Bronchial HyperreactivityTnf
Bronchial SpasmTnfrsf1b
BronchiectasisTnf
Bronchiectasis with or without Elevated Sweat Chloride 1Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 2Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 3Tnfrsf1a
Bronchiolitis, ViralTnf
Bronchopulmonary DysplasiaTnf , Txn1
BurnsTnf
CachexiaTnf , Tnfrsf1a
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, familial, 6Stat1
Candidiasis, familial, 7Stat1
Carbon Tetrachloride PoisoningFadd
Carcinoma, HepatocellularCasp8 , Cyld , Stat1 , Tnf
Carcinoma, Intraductal, NoninfiltratingRela
Carcinoma, Non-Small-Cell LungCasp8 , Cyld , Rela , Tnf , Tnfrsf1a
Carcinoma, Renal CellBirc2 , Birc3 , Cav1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Carcinoma, Small CellTnf
Carcinoma, Squamous CellCav1 , Rack1 , Ripk1 , Tnfrsf1a
Carcinoma, Squamous Cell of Head and NeckCasp8
Carcinoma, Transitional CellCav1 , Tnf
CardiomegalyCav1 , Rbck1 , Rela , Tnf
CardiomyopathiesMap3k5 , Tnf , Txn1
Cardiomyopathy, DilatedTnf , Txn1
Cardiomyopathy, Familial Hypertrophic, 4Madd
Cardiomyopathy, RestrictiveMap2k3
Cardiovirus InfectionsTnf
Carotid Artery InjuriesMap3k5
Cell Transformation, NeoplasticNfkb1 , Rela , Tnfaip3
Cerebral HemorrhageCasp8 , Nfkb1 , Rela , Sqstm1
Cerebral InfarctionMap3k5 , Tnf
Ceroid Lipofuscinosis, Neuronal, 6Smpd1
Cervical Intraepithelial NeoplasiaRela
Chlamydia InfectionsTnf
CholestasisRela , Tnf
Cholesteatoma, Middle EarRela , Tnf
ChorioamnionitisTnf
Choroidal NeovascularizationIkbkb
Chronic Allograft DysfunctionTnf
Chronic Cerebral HypoperfusionMap3k5
Cleft PalateChuk
Cocoon SyndromeChuk
Cognition DisordersMap3k5
ColitisAdam17 , Chuk , Ikbkb , Rela , Tnf
Colitis, ExperimentalTnf , Tnfrsf1a
Colonic NeoplasmsIkbkb , Map2k3 , Nfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Colorectal NeoplasmsCasp8 , Tnf
Congenital Heart Defects, Multiple Types, 2Tab2
Corneal UlcerTnf
Coronary Artery DiseaseTnf , Tnfrsf1a
Coronary RestenosisTnf
CoughTnf
Coxsackievirus InfectionsTnf
Craniofacial AbnormalitiesFadd
Crohn DiseaseTnf , Tnfrsf1a , Tnfrsf1b
CryoglobulinemiaTnf
Cryptogenic Organizing PneumoniaTnfrsf1a , Tnfrsf1b
CryptorchidismRela
Cystic FibrosisTnf , Tnfrsf1a
CystitisRela , Tnf
Cystitis, InterstitialTnf
Cytomegalovirus InfectionsStat1 , Tnf
Cytomegalovirus RetinitisTnf , Tnfrsf1a
Demyelinating DiseasesTnf
Dermal FibrosisCav1
DermatitisIkbkb , Sharpin , Tnf
Dermatitis HerpetiformisTnf
Dermatitis, Allergic ContactCasp8 , Tnf
Dermatitis, AtopicTnf
Dermatitis, ContactCasp8 , Txn1
DermatomyositisTnf
Diabetes MellitusCav1 , Map3k5
Diabetes Mellitus, ExperimentalCasp8 , Cav1 , Ikbkb , Map2k3 , Map3k5 , Prkci , Rela , Smpd1 , Stat1 , Tnf , Tnfrsf1a , Tnfrsf1b , Txn1
Diabetes Mellitus, Insulin-Dependent, 5Tab2
Diabetes Mellitus, Type 1Casp8 , Tnf
Diabetes Mellitus, Type 2Adam17 , Casp8 , Ikbkb , Nfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Diabetic AngiopathiesRela , Tnf
Diabetic CardiomyopathiesTnf
Diabetic NephropathiesRela , Tnf , Tnfrsf1a , Tnfrsf1b
Diabetic NeuropathiesCav1 , Tnf
Diabetic RetinopathyTnf
Disease Models, AnimalTnf
Disease ProgressionStat1
Disseminated Intravascular CoagulationTnf
Drug HypersensitivityTnf
Drug-Induced Liver InjuryCasp8 , Fadd , Map3k5 , Tnf
Drug-Related Side Effects and Adverse ReactionsTxn1
Dry Eye SyndromesTnf
Dyskinesia, Drug-InducedRela
Eales DiseaseTnf
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EdemaCasp8 , Tnf
EmphysemaTnf
EncephalitisRela , Tnf
EncephalomyelitisTnf
Encephalomyelitis, Autoimmune, ExperimentalAdam17 , Casp8 , Stat1 , Tnf
End Stage Liver DiseaseTnfrsf1a
Endometrial NeoplasmsTnfrsf1a , Tnfrsf1b
EndometriosisTnf , Tnfrsf1b
EndophthalmitisTnf
EndotoxemiaTnf
Enterocolitis, NecrotizingIkbkg , Map3k5 , Tnf
Enterovirus InfectionsTnfrsf1a
EosinophiliaSharpin
Erectile DysfunctionTnf
Erythema NodosumTnf
Esophageal NeoplasmsCasp8 , Map3k3
EsophagitisTnf
Esophagitis, PepticTnf
Exfoliation SyndromeCav1
Eye DiseasesTnf
Familial CylindromatosisCyld
Familial Mediterranean FeverTnfrsf1a
Familial Paget's Disease of BoneSqstm1
Fanconi AnemiaTnf
Farmer's LungTnf
FatigueTnfrsf1b
Fatty LiverBirc3 , Nfkb1 , Rela , Tnf , Txn1
Fetal DeathTnfrsf1b
Fetal DiseasesChuk
FeverTnf , Tnfrsf1a
Fibromatosis, AggressiveTnf
FibrosarcomaTnfrsf1a
FibrosisMap2k7 , Tnf
Forney Robinson Pascoe SyndromeMap3k7
Fractures, BoneTnfrsf1b
Frontometaphyseal Dysplasia 2Map3k7
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3Sqstm1
GastritisTnf
Gaucher DiseaseTnf
Genetic Diseases, InbornCav1
GlaucomaTnf , Txn1
Glaucoma, Open-AngleCav1 , Tnf
Glaucoma, Primary Open AngleCav1 , Tnf
GlioblastomaMap2k3
GliomaCav1 , Tnf
GlomerulonephritisTnf , Tnfrsf1a , Tnfrsf1b
Glomerulonephritis, IGATnf , Tnfrsf1a , Tnfrsf1b
Glomerulonephritis, MembranousMap3k5
GlomerulosclerosisTnfrsf1b
Glomerulosclerosis, Focal SegmentalTnf , Tnfrsf1a , Tnfrsf1b
Glucosephosphate Dehydrogenase DeficiencyIkbkg
Graves DiseaseTnf
Graves OphthalmopathyTnf
HeadacheTnfrsf1b
Hearing LossStat1 , Tnf
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedTnf
Hearing Loss, SensorineuralFadd , Tnf
Hearing Loss, SuddenTnf
Heart ArrestTnf
Heart FailureMap2k7 , Map3k5 , Tnf , Tnfrsf1a , Tnfrsf1b
Heat StrokeNfkb1 , Rela , Tnf
HemochromatosisTnf
Hemolytic-Uremic SyndromeTnf
HemorrhageCav1
Hepatic EncephalopathyTnf
Hepatitis C, ChronicTnfrsf1a
Hepatitis, AlcoholicTnf
Hepatolenticular DegenerationSmpd1 , Tnf
Hepatorenal SyndromeTnf
Hereditary Autoinflammatory DiseasesTnfaip3
Hernia, DiaphragmaticTnf
Hernias, Diaphragmatic, CongenitalTnf
Herpes ZosterTnf
Hidradenitis SuppurativaTnf
HIV InfectionsBirc2 , Birc3 , Tnf
HIV Wasting SyndromeTnf
Huntington DiseaseMap3k5 , Nfkb1
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaMap2k3 , Tnf , Tnfrsf1a , Tnfrsf1b
HyperbilirubinemiaTnf
HypercalcemiaTnf
HyperglycemiaCasp8 , Prkcz
HyperhomocysteinemiaTnf
HyperoxaluriaNfkb1
HyperoxiaFadd , Tnf , Tnfrsf1a
HyperplasiaCav1 , Ikbkb
HypersensitivityTnf , Tnfrsf1a , Tnfrsf1b
HypertensionCav1 , Fadd , Ikbkb , Rela , Sqstm1 , Tnf
Hypertension, PulmonaryCav1 , Rela , Tnf
Hypertension, RenalTnf
Hypertension, RenovascularRela
Hypertrophy, Left VentricularPrkcz , Rela
HypoalbuminemiaTnfrsf1b
HypoglycemiaTnf
HypotensionTnf
HypothermiaTnf
HypothyroidismCav1
Hypoxia-Ischemia, BrainMap3k5
Idiopathic Dilation CardiomyopathyTnf
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 31AStat1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
IMMUNODEFICIENCY, COMMON VARIABLE, 12Nfkb1
Immunologic Deficiency SyndromesCasp8
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaTnf
Incontinentia PigmentiIkbkg
Infarction, Middle Cerebral ArteryFadd , Ikbkb , Tnf
InfectionTnf
Infections, Recurrent, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsFadd
InflammationChuk , Tnf , Tnfaip3 , Tnfrsf1b
Inflammatory Bowel Disease 11Rela , Tnf
Inflammatory Bowel DiseasesIkbkb , Tnf
Inflammatory Skin and Bowel Disease, NeonatalAdam17
INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL 1Adam17
Influenza, HumanStat1 , Tnf , Tnfrsf1a
Insulin ResistanceIkbkb , Prkcz , Rela , Tnf , Tnfrsf1a
Intervertebral Disc DisplacementTnf , Tnfrsf1b
Intracranial AneurysmTnf
Intracranial HemorrhagesTnf
Intrahepatic Cholestasis of PregnancyTnf
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Irritable Bowel SyndromeIkbkg
IschemiaTnfrsf1a
Ischemic Attack, TransientCav1 , Ikbkb , Madd , Map3k5 , Nfkb1 , Rack1 , Tnf , Tnfrsf1a
Keratitis, HerpeticTnf
Keratoconjunctivitis SiccaTnf
Kidney DiseasesTnf , Tnfrsf1a
Kidney Failure, ChronicNfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Kidney Reperfusion InjuryIkbkb , Map3k5 , Tnf , Tnfrsf1a
LabyrinthitisTnf
Learning DisordersIkbkg
Legionnaires' DiseaseTnfrsf1a , Tnfrsf1b
LeiomyomaCav1
LeishmaniasisTnf
Leishmaniasis, CutaneousTnf
Leishmaniasis, MucocutaneousTnf
Leishmaniasis, VisceralTnf
LeprosyTnf
LeukemiaBirc2 , Birc3 , Fadd , Prkcz
Leukemia, Lymphocytic, Chronic, B-CellTnf
Leukemia, Myeloid, AcuteFadd
Leukomalacia, PeriventricularTnf
Lichen PlanusRipk1
Limb Deformities, CongenitalChuk
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
Lipodystrophy, Congenital Generalized, Type 3Cav1
Lipodystrophy, Familial PartialCav1
ListeriosisCyld , Tnf
Liver CirrhosisStat1 , Tnfrsf1b
Liver Cirrhosis, AlcoholicRela , Tnf
Liver Cirrhosis, BiliaryNfkb1 , Tnfrsf1a
Liver Cirrhosis, ExperimentalAdam17 , Birc3 , Cav1 , Rela , Tnf
Liver DiseasesNfkb1 , Tnf , Txn1
Liver Diseases, AlcoholicCav1
Liver Failure, AcuteTnf
Liver NeoplasmsCasp8 , Map2k3 , Tnf
Liver Reperfusion InjuryCasp8 , Fadd , Ikbkg , Tnf , Tnfrsf1a , Tradd
Low Tension GlaucomaCav1 , Tnf
Lung DiseasesTnf
Lung Diseases, FungalTnf
Lung InjuryTnf , Tnfrsf1a
Lung NeoplasmsCasp8 , Ikbkg , Map2k3 , Map2k7 , Tnf
Lung Reperfusion InjuryTnf
Lupus Erythematosus, SystemicTnf , Tnfaip3 , Tnfrsf1a , Tnfrsf1b
Lupus NephritisTnf , Tnfrsf1a , Tnfrsf1b
LymphangioleiomyomatosisStat1
Lymphatic MetastasisCav1 , Rela
LymphomaRela
Lymphoma, FollicularTnfaip3
Lymphoma, T-Cell, CutaneousTnfaip3
LymphopeniaTnf
Macular DegenerationSqstm1
MalariaTnf
Malaria, CerebralTnfrsf1b
Malaria, FalciparumTnf
Mammary Neoplasms, ExperimentalCasp8 , Cav1 , Map2k3 , Map2k7 , Rela , Stat1 , Tnf
Manganese PoisoningTnf
MastoiditisRela
MelanomaCasp8 , Cav1 , Map3k5 , Nfkb1 , Tnf
Melanoma, ExperimentalIkbkb
Meningitis, PneumococcalRela , Tnf
Mental Retardation, Autosomal Recessive 54Tnik
Mesothelioma, MalignantTxn1
Metabolic Syndrome XFadd , Tnf , Tnfrsf1a
Mevalonate Kinase DeficiencyTnf
Microphthalmia, Syndromic 1Adam17 , Map3k1
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
Migraine without AuraTnf
Mitochondrial MyopathiesTnf
Mixed Connective Tissue DiseaseTnf
Morphine DependenceFadd
Mouth NeoplasmsRack1
Mucocutaneous Lymph Node SyndromeTnf
Multiple Acyl Coenzyme A Dehydrogenase DeficiencyMadd
Multiple MyelomaTnf
Multiple Organ FailureTnf
Multiple SclerosisCav1 , Tnf , Tnfaip3 , Tnfrsf1a
Muscle WeaknessTnfrsf1a
Muscular AtrophyChuk , Ikbkb , Tnf
Muscular DystrophiesTnf
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterium Avium-Intracellulare InfectionTnf
Mycobacterium InfectionsStat1
Mycobacterium Infections, NontuberculousStat1
Mycosis FungoidesTnfrsf1b
Myelodysplastic SyndromesTnf
Myocardial InfarctionMap3k5 , Tnf , Tnfrsf1a , Tnfrsf1b , Txn1
Myocardial IschemiaMap2k3 , Tnf
Myocardial Reperfusion InjuryCasp8 , Fadd , Rela , Stat1 , Tnf , Txn1
Myocardial StunningTnf
MyocarditisTnf , Txn1
Myocarditis, Autoimmune, ExperimentalCav1
MyositisTnf
Nasal PolypsTnf , Tnfrsf1a , Tnfrsf1b
NauseaTnf
NecrosisTnf
Nematode InfectionsTnfrsf1a
NeointimaMap3k5
Neoplasm InvasivenessRela , Smpd1 , Tnf , Txn1
Neoplasm MetastasisCav1 , Fadd , Tnf
Neoplasms, ExperimentalRela , Tnf
Nephrogenic Fibrosing DermopathyCav1
Nerve DegenerationTnf
Nervous System DiseasesTnf
NeuralgiaTnf
Neuritis, Autoimmune, ExperimentalCav1 , Tnf
NEURODEGENERATION WITH ATAXIA, DYSTONIA, AND GAZE PALSY, CHILDHOOD-ONSETSqstm1
Neurogenic InflammationTnf , Tnfrsf1a , Tnfrsf1b
Neuroma, AcousticCav1
Neuropathy, PainfulTnf
NeutropeniaTnf
Niemann-Pick Disease, Intermediate, Protracted NeurovisceralSmpd1
Niemann-Pick Disease, Type ASmpd1
Niemann-Pick Disease, Type BSmpd1
Niemann-Pick DiseasesSmpd1
Non-alcoholic Fatty Liver DiseaseIkbkg , Tnf , Tnfrsf1b
Nonaka MyopathySqstm1
ObesityCav1 , Fadd , Ikbkb , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Optic Nerve InjuriesTnfrsf1a , Tradd
Oral Submucous FibrosisTnf
Osteitis DeformansSqstm1
OsteoarthritisCav1
OsteolysisTnf
OsteoporosisTnfrsf1b
Osteoporosis, PostmenopausalTnf
Otitis MediaRela , Tnf
Otitis Media with EffusionTnf
Ovarian CystsNfkb1
Ovarian NeoplasmsCav1 , Map2k7 , Prkci , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Oxygen-Induced RetinopathyTnf
PainTnf , Tnfrsf1a
Pancreatic NeoplasmsBag4 , Casp8 , Rela , Tnf
PancreatitisIkbkb
Pancreatitis, Acute NecrotizingRela
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Tnf
Papillomavirus InfectionsCasp8
ParacoccidioidomycosisTnf
Parkinson DiseaseMap3k5 , Tnf , Tnfrsf1b
Parkinsonian DisordersRela , Tnf , Tnfrsf1b
Pediatric Crohn's DiseaseTnf
Pemphigoid, Benign Mucous MembraneTnf
Periodic Fever, Familial, Autosomal DominantTnfrsf1a
PeriodontitisTnf
Peripheral Nerve InjuriesTnf
PeritonitisTnf
Picornaviridae InfectionsTnf
Placenta DiseasesTnf
PlasmacytomaTnf
Pleomorphic Xanthoastrocytoma Cav1 , Tax1bp1
Pleural EffusionTnf
PleurisyTnf
PneumoniaIkbkb , Tnf , Tnfrsf1a , Tnfrsf1b
Pneumonia, AspirationTnf
Pneumonia, BacterialChuk , Tnf , Tnfrsf1a , Tnfrsf1b
Pneumonia, MycoplasmaTnf
Pneumonia, PneumococcalTnf
Pneumonia, ViralTnf
Polychondritis, RelapsingTnf
Polycystic Ovary SyndromeTab1
POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCYRbck1
PolymyositisTnf , Tnfrsf1a , Tnfrsf1b
Pre-EclampsiaTnf , Tnfrsf1b
Precancerous ConditionsMap2k7
Precursor Cell Lymphoblastic Leukemia-LymphomaCasp8
Precursor T-Cell Lymphoblastic Leukemia-LymphomaStat1
Pregnancy Complications, CardiovascularTnf
Prostatic HyperplasiaRela
Prostatic Intraepithelial NeoplasiaMap2k7 , Rela
Prostatic NeoplasmsCav1 , Chuk , Map2k7 , Map3k7 , Prkcz , Rela , Stat1 , Tnf
PseudohypoaldosteronismTnfrsf1a
Pseudomonas InfectionsTnf , Tnfrsf1a
PsoriasisCav1 , Ikbkb , Tnf , Tnfaip3 , Tnfrsf1a
Pulmonary Disease, Chronic ObstructiveTnf , Tnfrsf1a , Tnfrsf1b
Pulmonary EdemaTnf
Pulmonary EmphysemaTnf
Pulmonary FibrosisCav1 , Stat1 , Tnf
Pulmonary Heart DiseaseTnf
Pulmonary Hypertension, Primary, 3Cav1
Radiation Injuries, ExperimentalTnf
Radiation PneumonitisTnf , Tnfrsf1a
RadiculopathyTnf
Renal FibrosisTnfrsf1a
Renal InsufficiencyTnfrsf1b
Reoviridae InfectionsStat1
Reperfusion InjuryCasp8 , Cav1 , Rela , Stat1 , Tnf , Tnfrsf1a , Txn1
Respiratory Distress Syndrome, AdultTnf , Tnfrsf1a , Tnfrsf1b
Respiratory HypersensitivityTnf
Respiratory Syncytial Virus InfectionsTnf
Respiratory Tract DiseasesTnf
Respiratory Tract InfectionsTnf
Retina Reperfusion InjuryTnf
Retinal Artery OcclusionTnf
Retinal DetachmentTnf , Tnfrsf1a , Tnfrsf1b
Retinal DiseasesMap2k3 , Tnf
Retinitis PigmentosaRipk1
RhinitisTnf
RhinosinusitisTnf
Sarcoidosis, PulmonaryTnf , Tnfrsf1b
SarcomaTnf
SarcopeniaCav1
SchizophreniaTnf
Schizophrenia, ChildhoodRela
Sciatic NeuropathyCav1 , Tnf , Tnfrsf1a , Tnfrsf1b
SciaticaTnfrsf1b
ScleritisTnf
Scleroderma, LimitedCav1
Scleroderma, LocalizedTnf
Scleroderma, SystemicCav1
ScrapieStat1
SeizuresMap3k5 , Tnf , Tnfrsf1a , Tnfrsf1b
SepsisCasp8 , Rela , Stat1 , Tnf
Sezary SyndromeTnfrsf1b
ShockTnf
Shock, HemorrhagicRela , Tnf
Shock, SepticTnf
SilicosisTnf , Tnfrsf1a
Sjogren's SyndromeTnf , Tnfaip3
Skin AbnormalitiesChuk
Skin DiseasesTnf , Tnik
Skin NeoplasmsCasp8 , Cyld , Rela
Sleep Apnea, ObstructiveRela , Tnf , Tnfrsf1a
Smith-Magenis SyndromeMap2k3 , Map3k3 , Rffl
Soft Tissue NeoplasmsTnf
Spastic Paraplegia, HereditaryMap4k5
Spinal Cord CompressionTnf , Tnfrsf1a , Tnfrsf1b
Spinal Cord InjuriesCav1 , Fadd , Map3k5 , Rela , Tnf , Tnfrsf1a
Spondylitis, AnkylosingTnfrsf1b
Status EpilepticusCasp8 , Rela , Tnf
Stevens-Johnson SyndromeCav1 , Tnf
Stomach NeoplasmsBirc2 , Casp8 , Cav1 , Tnf
Stomach UlcerTnf
Stomatognathic DiseasesFadd
StrokeTnf
Subarachnoid HemorrhageTnf
Systemic CandidiasisTnf
Systemic Inflammatory Response SyndromeTnfrsf1b
TachycardiaTnf
Telangiectasia, Hereditary HemorrhagicTnf
Temporomandibular Joint DisordersMap4k3 , Tnf
ThalassemiaTnf
ThrombocytopeniaTnf
ThrombosisTnf
ThymomaCyld
Thyroid NeoplasmsMap2k3 , Tnf
Thyroiditis, AutoimmuneTnf
Tongue NeoplasmsTnf
TrachomaTnf
Transplant RejectionIkbkb , Tnf , Tnfrsf1b
Trauma, Nervous SystemStat1
TrichinellosisTnf
Trichoepithelioma, Multiple Familial, 2Cyld
Trigeminal NeuralgiaTnf
TuberculosisTnf , Tnfrsf1b
Tuberculosis, MeningealTnf
Tuberculosis, PulmonaryTnf
Ureteral ObstructionTnf , Tnfrsf1a , Tnfrsf1b
Urinary Bladder NeoplasmsBirc3 , Cav1 , Rela , Tnf
UrticariaTnf
Uterine Cervical NeoplasmsBirc2 , Casp8 , Map2k3 , Rela , Tnf
UveitisRela , Tnf , Tnfrsf1a
Uveitis, AnteriorTnf
Uveitis, IntermediateTnf
Uveomeningoencephalitic SyndromeTnf
Uveoretinitis, Autoimmune, ExperimentalTnfrsf1a
Vascular DiseasesTnf
Vascular System InjuriesTnf
Venous ThromboembolismTnf
Ventilator-Induced Lung InjuryMap3k5
Ventricular DysfunctionTnf
Ventricular RemodelingMap3k5
VitiligoTnf
Vulvar VestibulitisTnf
Weight GainCav1 , Tnf
Weill-Marchesani SyndromeTnf
Wilms TumorStat1
Wounds and InjuriesTnf
Wounds, PenetratingTnf
Pathway Annotations Associated with Genes in the tumor necrosis factor mediated signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
adenine phoshoribosyltransferase deficiency pathwayTxn1
adenosine monophosphate deaminase deficiency pathwayTxn1
adenosine signaling pathwayChuk , Ikbkb , Map2k7 , Map3k1 , Nfkb1 , Prkcz
adenylosuccinate lyase deficiency pathwayTxn1
AICA-ribosuria pathwayTxn1
allograft rejection pathwayTnf
Alzheimer disease pathwayAdam17 , Casp8 , Fadd , Tnf , Tnfrsf1a
amyotrophic lateral sclerosis disease pathwayMap2k3 , Tnf , Tnfrsf1a , Tnfrsf1b
angiotensin II signaling pathwayPrkcz
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayBirc2 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Nfkb1 , Rela , Ripk1 , Tnf , Tnfrsf1a , Tradd , Traf2
asthma disease pathwayTnf
azathioprine pharmacodynamics pathwayTxn1
B cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap2k7 , Map3k1 , Map3k3 , Map3k7 , Traf2
ceramide signaling pathwayBag4 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Madd , Map3k1 , Map4k4 , Nfkb1 , Nsmaf , Prkcz , Rela , Ripk1 , Smpd1 , Stat1 , Tnf , Tnfrsf1a , Tradd , Traf2
chemokine mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Prkcz , Rela , Stat1
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
cytokine mediated signaling pathwayTnf , Tnfrsf1a , Tnfrsf1b
dilated cardiomyopathy pathwayTnf
eicosanoid signaling pathwayPrkcz
endocytosis pathwayCav1 , Itch , Prkci , Prkcz
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Traf2
Entamoeba histolyca infection pathwayNfkb1 , Rela , Tnf
ephrin - ephrin receptor bidirectional signaling axisMap3k7 , Map4k4
epidermal growth factor/neuregulin signaling pathwayAdam17 , Map2k7 , Prkcz , Stat1
Erk5 MAPK signaling pathwayMap3k3
erythropoietin signaling pathwayNfkb1 , Stat1
extrinsic apoptotic pathwayCasp8
FasL mediated signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k7 , Map3k1 , Ripk1 , Smpd1
Fc epsilon receptor mediated signaling pathwayMap2k3 , Map2k7 , Tnf
fibroblast growth factor signaling pathwayStat1
gonadotropin-releasing hormone signaling pathwayMap2k3 , Map2k7 , Map3k1 , Map3k3
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Stat1
hepatitis C virus infection pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Ripk1 , Stat1 , Tnf , Tnfrsf1a , Tradd , Traf2
Huntington disease pathwayCasp8
hypertrophic cardiomyopathy pathwayTnf
hypoxia inducible factor pathwayRack1
influenza A virus infection pathwayIkbkb , Map2k3 , Map2k7 , Nfkb1 , Rela , Stat1 , Tnf , Tnfrsf1a
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkci , Prkcz
insulin signaling pathwayCav1 , Ikbkb , Prkci , Prkcz
insulin-like growth factor signaling pathwayPrkcz , Rack1
integrin mediated signaling pathwaySharpin
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Map3k3 , Map3k7 , Nfkb1 , Prkci , Prkcz , Rela , Sqstm1 , Tab1 , Tab2 , Tab3
Interleukin-10 signaling pathwayStat1
interleukin-12 signaling pathwayMap2k3 , Nfkb1 , Rela , Stat1
interleukin-2 signaling pathwayStat1
interleukin-23 signaling pathwayNfkb1 , Rela , Stat1 , Tnf
interleukin-27 signaling pathwayStat1 , Tnf
interleukin-6 signaling pathwayAdam17 , Stat1
Jak-Stat signaling pathwayStat1
Kelley-Seegmiller syndrome pathwayTxn1
Leishmania infection pathwayMap3k7 , Nfkb1 , Rela , Stat1 , Tnf
Lesch-Nyhan syndrome pathwayTxn1
measles infection pathwayChuk , Map3k7 , Nfkb1 , Rack1 , Rela , Stat1
mercaptopurine pharmacodynamics pathwayTxn1
mitochondrial autophagy pathwaySqstm1
mitogen activated protein kinase signaling pathwayChuk , Ikbkb , Ikbkg , Map2k3 , Map2k7 , Map3k1 , Map3k3 , Map3k7 , Map4k2 , Map4k3 , Map4k4 , Nfkb1 , Rela , Tnf , Tnfrsf1a , Traf2
molybdenum cofactor deficiency pathwayTxn1
mTOR signaling pathwayIkbkb
Mycobacterium tuberculosis infection pathwayCasp8 , Fadd , Nfkb1 , Rela , Stat1 , Tnf , Tnfrsf1a , Tradd
myocarditis pathwayCasp8 , Cav1
neurotrophic factor signaling pathwayIkbkb , Map2k7 , Map3k1 , Map3k3 , Nfkb1 , Rela
NOD-like receptor signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rela , Tnf
Notch signaling pathwayAdam17 , Itch
nuclear factor kappa B signaling pathwayBirc2 , Chuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rbck1 , Rela , Rnf31 , Sharpin , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Sqstm1
p38 MAPK signaling pathwayMap2k3 , Map3k1 , Map3k3 , Map3k5 , Map3k7 , Tab1 , Tab2 , Traf2 , Txn1
p53 signaling pathwayCasp8
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Stat1
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Map3k5
Plasmodium infection pathwayTnf
platelet-derived growth factor signaling pathwayCav1 , Map2k7 , Stat1
primary immunodeficiency disease pathwayIkbkg
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
protein kinase C (PKC) signaling pathwayPrkci , Prkcz , Rack1
purine metabolic pathwayTxn1
purine nucleoside phosphorylase deficiency pathwayTxn1
Reelin signaling pathwayMap2k7
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Cyld , Fadd , Ikbkb , Ikbkg , Map3k1 , Map3k7 , Nfkb1 , Rela , Ripk1 , Tnf , Tradd , Traf2
reverse cholesterol transport pathwayCav1
rheumatoid arthritis disease pathwayTnf
ribosome biogenesis pathwayRack1
small cell lung cancer pathwayBirc2 , Birc3 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Traf2
sphingolipid metabolic pathwaySmpd1 , Smpd2
syndecan signaling pathwayRack1
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map2k7 , Map3k7 , Nfkb1 , Rela , Tnf
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1
tioguanine pharmacodynamics pathwayTxn1
titanium dioxide nanoparticle response pathwayCasp8
Toll-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k3 , Map2k7 , Map3k7 , Nfkb1 , Rela , Ripk1 , Stat1 , Tab1 , Tab2 , Tab3 , Tnf , Tradd
Toxoplasma gondii infection pathwayBirc2 , Birc3 , Casp8 , Chuk , Ikbkb , Ikbkg , Map2k3 , Map3k7 , Nfkb1 , Rela , Stat1 , Tnf , Tnfrsf1a
Trail mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Ripk1 , Smpd1 , Tradd , Traf2
transforming growth factor-beta Smad dependent signaling pathwayCav1 , Itch , Map3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayTnf
Trypanosoma brucei infection pathwayTnf
Trypanosoma cruzi infection pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Nfkb1 , Rela , Tnf , Tnfrsf1a
tumor necrosis factor mediated signaling pathwayAdam17 , Bag4 , Birc2 , Birc3 , Casp8 , Cav1 , Chuk , Cyld , Fadd , Ikbkb , Ikbkg , Itch , Madd , Map2k3 , Map2k7 , Map3k1 , Map3k3 , Map3k5 , Map3k7 , Map4k2 , Map4k3 , Map4k4 , Map4k5 , Nfkb1 , Nrk , Nsmaf , Prkci , Prkcz , Rack1 , Rbck1 , Rela , Rffl , Ripk1 , Rnf11 , Rnf31 , Sharpin , Smpd1 , Smpd2 , Sqstm1 , Stat1 , Tab1 , Tab2 , Tab3 , Tax1bp1 , Tnf , Tnfaip3 , Tnfrsf1a , Tnfrsf1b , Tnik , Tradd , Traf2 , Txn1
type 1 diabetes mellitus pathwayTnf
type 2 diabetes mellitus pathwayIkbkb , Prkcz , Tnf
type II interferon signaling pathwayMap3k1 , Stat1
ubiquitin/proteasome degradation pathwayBirc2 , Birc3 , Itch , Map3k1
vascular endothelial growth factor signaling pathwayCav1 , Map2k3 , Prkcz
Wnt signaling pathwayMap3k7
Wnt signaling, canonical pathwayCav1
Wnt signaling, non-canonical pathwayMap3k7 , Prkcz , Tab1 , Tab2
xanthinuria disease pathwayTxn1
xanthinuria disease pathway, type ITxn1
xanthinuria disease pathway, type IITxn1
Phenotype Annotations Associated with Genes in the tumor necrosis factor mediated signaling pathway

References Associated with the tumor necrosis factor mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: