INTEGRIN MEDIATED SIGNALING PATHWAY (PW:0000286)

View Ontology Report

Description

Integrin mediated signaling involves cell-cell and cell-extracellular matrix (ECM) specific protein interactions. Integrin alpha and beta subunits form the approximately 24 known pairs of receptor heterodimer complexes. In the absence of stimuli the receptors are in a low-affinity ligand binding state - the 'bent' conformation. Structural re-arrangements triggered by agonists give rise to the 'extended', high-affinity ligand binding state. The integrin mediated signaling is bi-directional: bindi

Pathway Diagram:

Ariadne Genomics Inc. Itgb1bp1 ---- Krit1 Tln1 Itga Itga ---- Sharpin Fabp3 ---- Itga Fblim1 ---- filamins cell motility cell differentiation cell proliferation cell survival PIP2 Fblim1 ---| filamins kindlins (Fermt) Ilk Sharpin ---| Itgb Fabp3 Sharpin Fabp3 ---| Itgb Itgb Fblim1 Krit1 Itgb1bp1 ---| Itgb Itgb ---- Itgb1bp1 Itgb1bp1 filamins ---| Itgb filamins ---- Itgb Itgb ---> invasion Ptk2 RTK, others Itgb ---- Tln1 Itgb ---- Tln2 kindlins (Fermt) --+> Itgb Itgb ---- kindlins (Fermt) Itga ---> cell adhesion Itga ---> invasion invasion Ilk ---- Parvb Parva ---- Pxn Nck2 ---- RTK, others Ilk ---- Lims1 Ilk ---- Pxn Ilk ---- Parva Lims1 ---- Nck2 Ptk2 ---- RTK, others Ptk2 ---- Tln1 Ilk ---- Parvg Apbb1ip ---- Tln2 Apbb1ip ---- Tln1 Tln1 --+> Itgb Tln2 cell surface proteins Itgb ---> cell migration Itga ---> cell migration Itga ---> ECM assembly Itgb ---> ECM assembly RTK, others ---> invasion ECM assembly cell migration ECM proteins cell adhesion Itgb ---> cell adhesion Krit1 ---| Itgb1bp1 Tln2 --+> Itgb Pxn Ptk2 ---- Pxn Ilk ---- Lims2 Lims2 Lims1 Ilkap Ilkap ---| Ilk Parvb Parva Parvg Apbb1ip Nck2 Ilk ---- Itgb filamins
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein JBrowse link 17 90,098,953 90,149,192 RGD:2300340
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:7364738
G Fblim1 filamin binding LIM protein 1 JBrowse link 5 160,122,466 160,158,921 RGD:7349373
G Fermt1 fermitin family member 1 JBrowse link 3 125,566,744 125,607,864 RGD:7349373
G Fermt2 fermitin family member 2 JBrowse link 15 19,807,806 19,876,557 RGD:7349373
G Fermt3 fermitin family member 3 JBrowse link 1 222,254,183 222,272,775 RGD:7349373
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:7364738
G Flnb filamin B JBrowse link 15 18,750,152 18,883,019 RGD:7364738
G Flnc filamin C JBrowse link 4 56,710,934 56,738,779 RGD:7364738
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:633110
RGD:2302091
RGD:2300344
G Ilkap ILK associated serine/threonine phosphatase JBrowse link 9 98,514,599 98,536,586 RGD:2300344
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:729264
RGD:5135538
G Itga10 integrin subunit alpha 10 JBrowse link 2 198,772,937 198,792,253 RGD:1358329
RGD:5135538
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:1358329
RGD:5135538
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:1302878
RGD:5135538
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,550 RGD:5135538
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:1358329
RGD:5135538
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1302879
RGD:5135538
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1300196
RGD:5135538
G Itga6 integrin subunit alpha 6 JBrowse link 3 58,442,904 58,515,124 RGD:1358329
RGD:5135538
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
RGD:5135538
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:633055
RGD:5135538
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:1358329
G Itgad integrin subunit alpha D JBrowse link 1 199,595,968 199,623,931 RGD:1358329
RGD:5135538
G Itgae integrin subunit alpha E JBrowse link 10 59,652,324 59,711,885 RGD:633077
RGD:5135538
G Itgal integrin subunit alpha L JBrowse link 1 198,744,053 198,781,745 RGD:1358329
RGD:5135538
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:1358329
RGD:5135538
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1358329
RGD:5135538
RGD:1625134
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:5135538
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874
RGD:5135538
RGD:1625134
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:7349373
RGD:7364738
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1358329
RGD:5135538
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:633129
RGD:5135538
RGD:1625134
G Itgb4 integrin subunit beta 4 JBrowse link 10 104,524,000 104,560,180 RGD:729025
RGD:5135538
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:724441
RGD:5135538
G Itgb6 integrin beta 6 JBrowse link 3 46,652,624 46,775,362 RGD:1358329
RGD:5135538
G Itgb7 integrin subunit beta 7 JBrowse link 7 143,820,236 143,837,802 RGD:633040
RGD:5135538
G Itgb8 integrin subunit beta 8 JBrowse link 6 147,089,280 147,172,846 RGD:1358329
RGD:5135538
G Krit1 KRIT1, ankyrin repeat containing JBrowse link 4 27,438,609 27,473,150 RGD:7349373
RGD:7364738
G Lims1 LIM zinc finger domain containing 1 JBrowse link 20 27,895,981 28,004,767 RGD:2300344
G Lims2 LIM zinc finger domain containing 2 JBrowse link 18 24,707,951 24,746,159 RGD:2300344
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:2300344
G Parva parvin, alpha JBrowse link 1 177,249,302 177,408,160 RGD:2300344
G Parvb parvin, beta JBrowse link 7 125,189,827 125,275,977 RGD:2300344
G Parvg parvin, gamma JBrowse link 7 125,288,081 125,307,587 RGD:2300344
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:2300402
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:2300344
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7349373
RGD:7364738
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:2300340
RGD:7349373
G Tln2 talin 2 JBrowse link 8 73,009,980 73,441,536 RGD:7349373
altered integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:1302875
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1302879
RGD:5490966
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1302875
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:633055
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupfilaminsfilamin activators
Functional ClassItgaintegrin alpha subunit
Functional ClassItgbintegrin beta subunit
Gene Groupkindlins (Fermt)kindlin activators

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the integrin mediated signaling pathway
Pathway TermsGene Symbols
abciximab pharmacodynamics pathwayItga2b , Itgb3
altered integrin mediated signaling pathwayIlk , Itga1 , Itga11 , Itga4 , Itga5 , Itga7 , Itga8 , Itga9 , Itgb1
altered Reelin signaling pathwayItga3 , Itgb1
arrhythmogenic right ventricular cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
calcium signaling pathway via the calcium-sensing receptorFlna
cell-extracellular matrix signaling pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
chemokine mediated signaling pathwayPtk2 , Pxn
dilated cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
E-cadherin signaling pathwayItgae , Itgb7
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaFabp3 , Ilk
endometrial cancer pathwayIlk
Entamoeba histolyca infection pathwayItgam , Itgb2 , Ptk2
ephrin - ephrin receptor bidirectional signaling axisItga2b , Itgb3 , Nck2 , Pxn
epidermal growth factor/neuregulin signaling pathwayNck2 , Ptk2 , Tln1
eptifibatide pharmacodynamics pathwayItga2b , Itgb3
glomerulonephritis pathwayItga8 , Itgb1
hypertrophic cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
hypoxia inducible factor pathwayItgb2
insulin signaling pathwayNck2
insulin-like growth factor signaling pathwayNck2 , Pxn
integrin mediated signaling pathwayApbb1ip , Fabp3 , Fblim1 , Fermt1 , Fermt2 , Fermt3 , Flna , Flnb , Flnc , Ilk , Ilkap , Itga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga3 , Itga4 , Itga5 , Itga6 , Itga7 , Itga8 , Itga9 , Itgad , Itgae , Itgal , Itgam , Itgav , Itgax , Itgb1 , Itgb1bp1 , Itgb2 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8 , Krit1 , Lims1 , Lims2 , Nck2 , Parva , Parvb , Parvg , Ptk2 , Pxn , Sharpin , Tln1 , Tln2
interleukin-4 signaling pathwayItgb3
Leishmania infection pathwayItga4 , Itgam , Itgb1 , Itgb2
long term potentiationPtk2
mitogen activated protein kinase signaling pathwayFlna , Flnb , Flnc
mTOR signaling pathwayPxn
Mycobacterium tuberculosis infection pathwayItgam , Itgax , Itgb2
myocardial infarction pathwayItga1 , Itga5
myocarditis pathwayItgal , Itgb2
nuclear factor kappa B signaling pathwaySharpin
pancreatic cancer pathwayIlk , Itga11 , Itga4 , Itga9
phagocytosis pathwayItga2 , Itga5 , Itgam , Itgb1 , Itgb2 , Itgb3 , Itgb5
Plasmodium infection pathwayItgal , Itgb2
platelet aggregation pathwayItgb3
platelet-derived growth factor signaling pathwayItgav , Itgb3 , Nck2
Reelin signaling pathwayItga3 , Itgb1 , Nck2
rheumatoid arthritis disease pathwayItgal , Itgb2
Rho/Rac/Cdc42 mediated signaling pathwayFlna
small cell lung cancer pathwayItga2 , Itga2b , Itga6 , Itgb1 , Ptk2
sphingosine 1-phosphate signaling pathwayItgav , Itgb3
Staphylococcus aureus infection pathwayItgal , Itgam , Itgb2
syndecan signaling pathwayItga2 , Itga5 , Itgb1
T cell receptor signaling pathwayNck2
tirofiban pharmacodynamics pathwayItga2b , Itgb3
Toxoplasma gondii infection pathwayItga6 , Itgb1
tumor necrosis factor mediated signaling pathwaySharpin
vascular endothelial growth factor signaling pathwayItgav , Itgb3 , Nck2 , Ptk2 , Pxn
Wnt signaling, non-canonical pathwayFlna
Phenotype Annotations Associated with Genes in the integrin mediated signaling pathway

References Associated with the integrin mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: