NUCLEAR FACTOR KAPPA B SIGNALING PATHWAY (PW:0000499)

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Description

Nuclear Factor kappa B (NF-kB) signaling pathway is essential for the proper functioning of the immune system. NF-kB pathway regulates the expression of cytokines, growth factors and other regulatory proteins; its signaling is set in motion in response to the activation of upstream pathways. Tumor necrosis factor (Tnf) alpha via tumor necrosis receptor R1, interleukin-1 via interleukin receptor 1 and lipopolysaccharide (LPS) triggered Toll-like receptors pathways converge on the activation of th

Pathway Diagram:

Elsevier Inc. Nfkb2 RELB K63-ubiquitin M1-Ubiquitin M1-ubiquitination miRNA in NF-kB LUBAC complex SCF ubiquitin ligase complex K63-polyubiquitination NF-kB target genes Tnf receptor superfamily, other upstream activators adapters adapters ---- Ikbkg adapters --+> Map3k14 SCF ubiquitin ligase complex ---| Nfkbia Rel Map3k14 --+> Chuk Chuk Map3k14 Ikbkb ---> Nfkbia Ikbkb ---> Nfkbib Ikbkb ---> Nfkbie Nfkbia Ikbkb Nfkbib K63-ubiquitin ---- Tab3 K63-ubiquitin ---- Tab2 Ikbkg ---- K63-ubiquitin Ikbkg Map3k7 Nfkbie Ikbkb ---- Ikbkg Ikbkg ---- M1-Ubiquitin Nfkbia ---- Rela Nfkbia ---| Rela Nfkb1 ---- Nfkbia Nfkbib ---- Rela Nfkbib ---| Rela Chuk ---- Ikbkg SCF ubiquitin ligase complex ---| Nfkbib SCF ubiquitin ligase complex ---| Nfkbie Chuk ---- Ikbkb Chuk --+> Nfkb2 NF-kB target genes ---> Nfkbia Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb1 ---> NF-kB target genes Rel ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes miRNA in NF-kB ---> NF-kB target genes NF-kB target genes ---> miRNA in NF-kB Rela Nfkb1 Map3k7 --+> Ikbkb LUBAC complex ---> Ikbkg Cyld Tab2 Tab3 Tab1 Cyld ---| K63-polyubiquitination adapters --+> Map3k7 Cyld ---| Map3k7
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Genes in Pathway:

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nuclear factor kappa B signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6484113
G Bcl10 B-cell CLL/lymphoma 10 JBrowse link 2 251,805,392 251,814,957 RGD:6484113
G Bcl3 B-cell CLL/lymphoma 3 JBrowse link 1 80,730,758 80,745,273 RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:5490225
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:2292172
RGD:6484113
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:6484113
G Csnk2a2 casein kinase 2 alpha 2 JBrowse link 19 9,972,537 10,012,043 RGD:6484113
G Csnk2b casein kinase 2 beta JBrowse link 20 5,108,692 5,113,675 RGD:6484113
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:5490225
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:6484113
RGD:7800734
RGD:7800735
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:2292172
RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:2292172
RGD:6484113
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128786
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6484113
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:6484113
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:2292172
RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490225
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:2292172
RGD:6484113
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:2292172
RGD:6484113
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:2292172
RGD:6484113
G Nfkbib NFKB inhibitor beta JBrowse link 1 86,941,073 86,948,845 RGD:2292172
G Nfkbie NFKB inhibitor epsilon JBrowse link 9 17,828,405 17,835,240 RGD:2292172
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6484113
G Ran RAN, member RAS oncogene family JBrowse link 12 31,319,556 31,324,105 RGD:6484113
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:7800730
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:5490225
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:2292172
RGD:6484113
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:2292172
RGD:6484113
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:6484113
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:6484113
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:7800730
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7800730
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:5490225
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490225
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490225
G Tab3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490225
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6484113
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6484113
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 JBrowse link 2 240,626,198 240,655,874 RGD:6484113
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupmiRNA in NF-kB
Gene GroupNF-kB target geneslink to a comprehensive list of NF-kB targets and website
ComplexLUBAC complexM1-ubiqutin
ComplexSCF ubiquitin ligase complextargets Nf-kB inhibitory proteins for degradation

Pathway Gene Annotations

Disease Annotations Associated with Genes in the nuclear factor kappa B signaling pathway
Disease TermsGene Symbols
Abnormalities, MultipleChuk
Acne VulgarisTnf , Tnfrsf1a
Acquired Immunodeficiency SyndromeTnf , Tnfrsf1a
Acute Coronary SyndromeTnf
Acute Kidney InjuryTnf , Tnfrsf1a
Acute Lung InjuryNod2 , Tnf
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaNfkb1 , Pik3ca , Tnf
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungPik3ca
ADENOCARCINOMA OF STOMACHPik3ca
Adenocarcinoma, ProstaticPik3ca , Xpo1
Adenoma, ColorectalTnfrsf1a
Adrenocortical CarcinomaPik3ca
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AlbuminuriaTnf
Alveolar Bone LossTnf
Alveolitis, Extrinsic AllergicTnf , Tnfrsf1a
Alzheimer DiseaseAtm , Ikbkb , Mapk14 , Pik3r1 , Tnf
Amphetamine-Related DisordersArrb2 , Rela
AmyloidosisTnf , Tnfrsf1a
Amyotrophic Lateral SclerosisMapk14 , Tnf
Amyotrophic Lateral Sclerosis 1Tnf
AnemiaTnf , Tnfrsf1a
Anemia, AplasticTnf
Anemia, Hypochromic MicrocyticTnf
Anemia, Iron-DeficiencyTnf
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
Anemia, RefractoryTnf
Anemia, Sickle CellTnf
Angina, StableTnf
AnorexiaTnf , Tnfrsf1a
AnthracosisTnf
Anti-Glomerular Basement Membrane DiseaseMapk14 , Syk , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTnf , Tnfrsf1a
Anxiety DisordersTnf
Apraxia, Oculomotor, Cogan TypeAtm
Arsenic PoisoningTnf
ArteriosclerosisAtm , Rela , Tnfrsf1a
Arteriovenous FistulaArrb2
Arthritis, ExperimentalArrb2 , Ikbkb , Ikbkg , Nod2 , Tnf , Tnfrsf1a
Arthritis, InfectiousTnf
Arthritis, PsoriaticNod2 , Tnf
Arthritis, RheumatoidNfkbie , Rel , Tnf , Tnfrsf1a , Traf6
AsbestosisTnf
Aspergillosis, Allergic BronchopulmonaryTnf , Tnfrsf1a
AsthmaChuk , Irf1 , Nod2 , Tnf , Tnfrsf1a
Asthma, OccupationalPrkca , Tnf
Ataxia TelangiectasiaAtm
Ataxia-Telangiectasia VariantAtm
AtherosclerosisNod2 , Tnf
Atrial FibrillationTnf
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autistic DisorderTnf
Autoimmune DiseasesNod2 , Tnfrsf1a
BacteremiaNod2
Bacterial InfectionsNod2
Barrett EsophagusRela
Behcet SyndromeIkbkg , Nod2 , Tnf , Tnfrsf1a
BerylliosisTnf
Beta-ThalassemiaTnf
bladder urothelial carcinomaPik3ca
Blau syndromeNod2
Bone Diseases, DevelopmentalChuk
Brain EdemaTnf
Brain InjuriesIrf1 , Rela , Tnf , Tnfrsf1a
Brain IschemiaNfkb1 , Nfkbia , Prkca , Rela , Src , Tnf , Tnfrsf1a
Brain NeoplasmsRela
Breast AdenocarcinomaPik3ca
Breast Cancer, FamilialAtm
Breast NeoplasmsAtm , Birc2 , Csnk2a1 , Ikbkb , Nfkbia , Nod2 , Pik3ca , Pik3r1 , Prkca , Rel , Rela , Relb , Src , Tnf , Xpo1
Bronchial HyperreactivityTnf
BronchiectasisTnf
Bronchiectasis with or without Elevated Sweat Chloride 1Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 2Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 3Tnfrsf1a
Bronchiolitis ObliteransNod2
Bronchiolitis, ViralTnf
Bronchopulmonary DysplasiaTnf
Burkitt LymphomaPik3r1
BurnsTnf
CachexiaTnf , Tnfrsf1a
CarcinomaPik3r1 , Ran
Carcinoma, Adenoid CysticAtm , Pik3ca
Carcinoma, Basal CellPik3ca
Carcinoma, HepatocellularAtm , Cyld , Nfkbia , Pik3ca , Tnf
Carcinoma, Intraductal, NoninfiltratingPrkca , Rela , Src
Carcinoma, Large CellPrkca
Carcinoma, Non-Small-Cell LungCyld , Irf1 , Pik3ca , Rela , Tnf , Tnfrsf1a
Carcinoma, Renal CellAtm , Birc2 , Pik3ca , Rela , Tnf , Tnfrsf1a
Carcinoma, Small CellTnf
Carcinoma, Squamous CellAtm , Csnk2a1 , Csnk2a2 , Csnk2b , Pik3ca , Tnfrsf1a
Carcinoma, Squamous Cell of Head and NeckPik3ca
Carcinoma, Transitional CellPik3ca , Rel , Relb , Tnf
Cardiac FibrosisNfkbia
CardiomegalyPrkca , Rbck1 , Rela , Src , Tnf
CardiomyopathiesMapk14 , Tnf
Cardiomyopathy, DilatedAtm , Lck , Prkca , Tnf
Cardiomyopathy, RestrictiveMapk14
Cardiovirus InfectionsTnf
CataractAtm
Cell Transformation, NeoplasticNfkb1 , Rela
Cerebellar AtaxiaAtm
Cerebral HemorrhageNfkb1 , Nfkb2 , Nfkbia , Rela , Relb
Cerebral InfarctionTnf
Cervical Intraepithelial NeoplasiaRela
Chlamydia InfectionsTnf
CholestasisMapk14 , Rela , Tnf
Cholesteatoma, Middle EarRela , Tnf
ChorioamnionitisTnf
Choroidal NeovascularizationIkbkb
Chronic Allograft DysfunctionTnf
Chronic Cerebral HypoperfusionMapk14
Chronic Lymphoid LeukemiaXpo1
Cleft PalateChuk
Cocoon SyndromeChuk
Cognition DisordersMapk14
ColitisChuk , Ikbkb , Nod2 , Rela , Src , Tnf
Colitis, ExperimentalNfkbia , Nod2 , Tnf , Tnfrsf1a
colon cancerBcl10 , Pik3ca
Colonic NeoplasmsBcl10 , Ikbkb , Nfkb1 , Nod2 , Pik3ca , Pik3r1 , Rela , Src , Tnf , Tnfrsf1a
colorectal cancerBcl10 , Pik3ca
Colorectal NeoplasmsBcl10 , Pik3ca , Pik3r1 , Src , Tnf , Xpo1
Common Variable ImmunodeficiencyNfkb2
Congenital Heart Defects, Multiple Types, 2Tab2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctivitis, AllergicIrf1 , Lck
Corneal UlcerTnf
Coronary Artery DiseaseNod2 , Tnf , Tnfrsf1a , Traf6
Coronary RestenosisTnf
CoughTnf
COWDEN SYNDROME 5Pik3ca
Coxsackievirus InfectionsTnf
Crohn DiseaseNod2 , Tnf , Tnfrsf1a
CryoglobulinemiaTnf
Cryptogenic Organizing PneumoniaTnfrsf1a
CryptorchidismNfkbia , Rela
Currarino TriadPik3ca
Cystic FibrosisIrf1 , Tnf , Tnfrsf1a
CystitisRela , Tnf
Cystitis, InterstitialTnf
Cytomegalovirus InfectionsTnf
Cytomegalovirus RetinitisTnf , Tnfrsf1a
Demyelinating DiseasesTnf
DermatitisIkbkb , Nod2 , Sharpin , Tnf
Dermatitis HerpetiformisTnf
Dermatitis, Allergic ContactTnf
Dermatitis, AtopicRelb , Tnf
DermatomyositisTnf
Diabetes Insipidus, NephrogenicPrkca
Diabetes Mellitus, ExperimentalIkbkb , Nfkb2 , Nfkbia , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a
Diabetes Mellitus, Insulin-Dependent, 5Tab2
Diabetes Mellitus, Type 1Ran , Tnf
Diabetes Mellitus, Type 2Ikbkb , Nfkb1 , Pik3r1 , Rela , Src , Tnf , Tnfrsf1a
Diabetic AngiopathiesRela , Tnf
Diabetic CardiomyopathiesTnf
Diabetic NephropathiesMapk14 , Rela , Tnf , Tnfrsf1a
Diabetic NeuropathiesMapk14 , Tnf
Diabetic RetinopathyTnf
Disease Models, AnimalTnf
Disseminated Intravascular CoagulationTnf
Drug HypersensitivityTnf
Drug-Induced Liver InjuryTnf
Dry Eye SyndromesTnf
Dyskinesia, Drug-InducedRela
Eales DiseaseTnf
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Anhidrotic, with T-Cell Immunodeficiency, Autosomal DominantNfkbia
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EdemaTnf
EmphysemaTnf
EncephalitisNfkbia , Rela , Tnf
EncephalomyelitisTnf
Encephalomyelitis, Autoimmune, ExperimentalTnf
End Stage Liver DiseaseTnfrsf1a
Endometrial NeoplasmsAtm , Irf1 , Pik3ca , Prkca , Tnfrsf1a
EndometriosisNfkbia , Tnf
EndophthalmitisTnf
EndotoxemiaMapk14 , Tnf
Enterocolitis, NecrotizingIkbkg , Nod2 , Tnf
Enterovirus InfectionsTnfrsf1a
EosinophiliaSharpin
Epidermal NevusPik3ca
Erectile DysfunctionTnf
Erythema NodosumTnf
Esophageal NeoplasmsPik3ca
EsophagitisTnf
Esophagitis, PepticTnf
Eye DiseasesTnf
Facial AsymmetryPik3ca
Familial CylindromatosisCyld
Familial Mediterranean FeverNod2 , Tnfrsf1a
Fanconi AnemiaTnf
Farmer's LungTnf
Fatty LiverNfkb1 , Rela , Tnf
Fetal DiseasesChuk
FeverTnf , Tnfrsf1a
Fibromatosis, AggressiveTnf
FibrosarcomaTnfrsf1a
FibrosisAtm , Tnf
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal Dysplasia 2Map3k7
GastritisNfkbia , Nod2 , Tnf
Gastrointestinal NeoplasmsPik3ca
Gaucher DiseaseTnf
Genetic Diseases, InbornAtm
GlaucomaTnf
Glaucoma, Open-AngleTnf
Glaucoma, Primary Open AngleTnf
GlioblastomaPik3ca , Pik3r1
GliomaPik3ca , Tnf
GlomerulonephritisTnf , Tnfrsf1a
Glomerulonephritis, IGATnf , Tnfrsf1a
Glomerulosclerosis, Focal SegmentalTnf , Tnfrsf1a
Glucosephosphate Dehydrogenase DeficiencyIkbkg
Graft vs Host DiseaseNod2
GranulomaNod2
Graves DiseaseTnf
Graves OphthalmopathyTnf
Growth DisordersPik3ca
Hamartoma Syndrome, MultiplePik3ca
Head and Neck NeoplasmsPik3ca
Hearing LossTnf
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedTnf
Hearing Loss, SensorineuralTnf
Hearing Loss, SuddenTnf
Heart ArrestTnf
Heart DiseasesMapk14
Heart FailurePrkca , Tnf , Tnfrsf1a
Heat StrokeNfkb1 , Nfkb2 , Rel , Rela , Relb , Tnf
HemimegalencephalyPik3ca
HemochromatosisTnf
Hemolytic-Uremic SyndromeTnf
Hepatic EncephalopathyTnf
Hepatitis C, ChronicTnfrsf1a
Hepatitis, AlcoholicTnf
Hepatolenticular DegenerationTnf
Hepatorenal SyndromeTnf
Hereditary Breast and Ovarian Cancer SyndromeAtm
Hernia, DiaphragmaticTnf
Hernias, Diaphragmatic, CongenitalTnf
Herpes ZosterTnf
Hidradenitis SuppurativaTnf
HIV InfectionsBirc2 , Lck , Ran , Tnf
HIV Wasting SyndromeTnf
Hodgkin DiseaseNfkbia , Rel
Huntington DiseaseNfkb1
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaTnf , Tnfrsf1a
HyperbilirubinemiaTnf
HypercalcemiaTnf
HypercholesterolemiaAtm
HyperhomocysteinemiaTnf
HyperoxaluriaNfkb1
HyperoxiaTnf , Tnfrsf1a
HyperplasiaIkbkb , Pik3ca
HypersensitivityTnf , Tnfrsf1a
HypertensionIkbkb , Nfkbia , Pik3r1 , Prkca , Rela , Src , Tnf
Hypertension, PortalPik3r1
Hypertension, PulmonaryRela , Tnf
Hypertension, RenalTnf
Hypertension, RenovascularRela
Hypertrophy, Left VentricularPrkca , Rela
Hypertrophy, Right VentricularPrkca
Hypoglossal Nerve InjuriesCsnk2b
HypoglycemiaPik3r1 , Tnf
HypotensionTnf
HypothermiaTnf
Idiopathic Dilation CardiomyopathyTnf
Immunodeficiency 12Malt1
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 22Lck
Immunodeficiency 36Pik3r1
IMMUNODEFICIENCY 37Bcl10
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
IMMUNODEFICIENCY, COMMON VARIABLE, 12Nfkb1
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaTnf
Incontinentia PigmentiIkbkg
Infarction, Middle Cerebral ArteryIkbkb , Nfkbia , Nod2 , Tnf
InfectionTnf
InfertilityAtm
InflammationChuk , Tnf
Inflammatory Bowel Disease 11Nod2 , Rela , Ripk2 , Tnf
Inflammatory Bowel DiseasesIkbkb , Nod2 , Tnf
Influenza, HumanTnf , Tnfrsf1a
Insulin ResistanceAtm , Ikbkb , Pik3r1 , Rela , Tnf , Tnfrsf1a
Intervertebral Disc DisplacementTnf
Intestinal DiseasesNod2
Intestinal NeoplasmsPrkca
Intracranial AneurysmTnf
Intracranial HemorrhagesTnf
Intrahepatic Cholestasis of PregnancyTnf
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Irritable Bowel SyndromeIkbkg
IschemiaPrkca , Tnfrsf1a
Ischemic Attack, TransientIkbkb , Nfkb1 , Nod2 , Tnf , Tnfrsf1a
KeloidRan
Keratitis, HerpeticTnf
Keratoconjunctivitis SiccaTnf
Keratoconus 1Skp1
Keratosis, SeborrheicPik3ca
Kidney DiseasesRelb , Tnf , Tnfrsf1a
Kidney Failure, ChronicNfkb1 , Rela , Tnf , Tnfrsf1a
Kidney Reperfusion InjuryAtm , Ikbkb , Src , Tnf , Tnfrsf1a
LabyrinthitisTnf
Laryngeal NeoplasmsNod2
Learning DisordersIkbkg
Legionnaires' DiseaseNod2 , Tnfrsf1a
LeiomyomaCsnk2b
LeishmaniasisTnf
Leishmaniasis, CutaneousTnf
Leishmaniasis, MucocutaneousTnf
Leishmaniasis, VisceralTnf
LeprosyNod2 , Tnf
LeukemiaAtm , Birc2
Leukemia, Lymphocytic, Chronic, B-CellAtm , Tnf , Xpo1
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveMapk14
Leukemia, Prolymphocytic, T-CellAtm
Leukemia-Lymphoma, Adult T-CellCsnk2a1 , Csnk2b
Leukomalacia, PeriventricularTnf
Limb Deformities, CongenitalChuk
ListeriosisCyld , Tnf
Liver Cirrhosis, AlcoholicRela , Tnf
Liver Cirrhosis, BiliaryNfkb1 , Tnfrsf1a
Liver Cirrhosis, ExperimentalArrb2 , Nfkbia , Nfkbie , Rela , Tnf
Liver DiseasesNfkb1 , Tnf
Liver Failure, AcuteAtm , Tnf
Liver NeoplasmsMapk14 , Pik3ca , Tnf
Liver Neoplasms, ExperimentalArrb2
Liver Reperfusion InjuryIkbkg , Tnf , Tnfrsf1a
Long QT SyndromeSyk
Low Tension GlaucomaTnf
lung cancerPik3ca
Lung DiseasesIrf1 , Tnf
Lung Diseases, FungalTnf
Lung InjuryNfkbia , Tnf , Tnfrsf1a
Lung NeoplasmsIkbkg , Irf1 , Mapk14 , Nod2 , Pik3ca , Tnf
Lung Reperfusion InjuryTnf
Lupus Erythematosus, SystemicNod2 , Tnf , Tnfrsf1a
Lupus NephritisTnf , Tnfrsf1a
Lyme DiseaseNod2
Lymphatic MetastasisPik3ca , Rela
LymphomaAtm , Malt1 , Rela
Lymphoma, B-CellAtm
Lymphoma, B-Cell, Marginal ZoneBcl10
Lymphoma, FollicularBcl10
Lymphoma, Large B-Cell, DiffuseMalt1 , Nfkbia , Pik3ca
Lymphoma, Mantle-CellAtm
Lymphoma, Non-HodgkinBcl10 , Malt1 , Pik3ca
Lymphoma, T-Cell, CutaneousAtm , Nfkb2
Lymphoma, T-Cell, PeripheralAtm
LymphopeniaTnf
MalariaTnf
Malaria, FalciparumTnf
Male Germ Cell TumorBcl10
Malformations of Cortical DevelopmentPik3ca
Mammary Neoplasms, AnimalPik3r1 , Ran , Rel , Relb
Mammary Neoplasms, ExperimentalCsnk2a1 , Pik3r1 , Ran , Rela , Relb , Tnf
Manganese PoisoningTnf
MastoiditisRela
MedulloblastomaPik3ca
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
MelanomaAtm , Nfkb1 , Nfkbia , Nfkbie , Pik3ca , Pik3r1 , Syk , Tnf
Melanoma, ExperimentalIkbkb
Memory DisordersRel
Meningitis, MeningococcalNod2
Meningitis, PneumococcalNod2 , Rela , Tnf
MesotheliomaBcl10 , Syk
Mesothelioma, MalignantBcl10
Metabolic Syndrome XAtm , Tnf , Tnfrsf1a
MetaplasiaNod2
Mevalonate Kinase DeficiencyTnf
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
Migraine without AuraTnf
Mitochondrial MyopathiesTnf
Mixed Connective Tissue DiseaseTnf
Mixed Tumor, MullerianPik3ca , Pik3r1
Mouth NeoplasmsPik3ca
Mucocutaneous Lymph Node SyndromeTnf
Multiple MyelomaNfkbia , Pik3ca , Tnf
Multiple Organ FailureTnf
Multiple SclerosisTnf , Tnfrsf1a
Multiple Sclerosis, Relapsing-RemittingNod2
Muscle WeaknessTnfrsf1a
Muscular AtrophyChuk , Ikbkb , Relb , Tnf
Muscular DystrophiesTnf
Mycobacterium Avium-Intracellulare InfectionTnf
Myelodysplastic SyndromesTnf
Myocardial InfarctionAtm , Csnk2a1 , Csnk2b , Nfkbia , Tnf , Tnfrsf1a
Myocardial IschemiaIrf1 , Mapk14 , Nfkbia , Tnf
Myocardial Reperfusion InjuryMapk14 , Nfkbia , Rela , Tnf
Myocardial StunningTnf
MyocarditisTnf
MyositisTnf
Nasal PolypsTnf , Tnfrsf1a
Nasopharyngeal CarcinomaPik3ca
Nasopharyngeal NeoplasmsPik3ca
NauseaTnf
NecrosisTnf
Nematode InfectionsPik3r1 , Tnfrsf1a
Neoplasm InvasivenessRela , Src , Tnf
Neoplasm MetastasisSrc , Tnf
NeoplasmsAtm , Pik3ca , Pik3r1 , Src
Neoplasms, ExperimentalRela , Tnf
Neoplastic Syndromes, HereditaryAtm , Pik3ca
Nerve DegenerationTnf
Nervous System DiseasesTnf
NeuralgiaTnf
Neuritis, Autoimmune, ExperimentalTnf
NeuroblastomaPik3ca
Neurogenic InflammationTnf , Tnfrsf1a
Neuropathy, PainfulTnf
NeutropeniaTnf
Non-alcoholic Fatty Liver DiseaseIkbkg , Tnf
ObesityIkbkb , Pik3r1 , Rela , Tnf , Tnfrsf1a
OKUR-CHUNG NEURODEVELOPMENTAL SYNDROMECsnk2a1
Optic Nerve InjuriesTnfrsf1a
Oral Submucous FibrosisTnf
OsteoarthritisRan
OsteolysisTnf
OsteoporosisAtm , Mapk14
Osteoporosis, PostmenopausalTnf
Otitis MediaRela , Tnf
Otitis Media with EffusionTnf
Ovarian CystsNfkb1
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsNod2 , Pik3ca , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a
Oxygen-Induced RetinopathyCsnk2a1 , Csnk2a2 , Csnk2b , Tnf
PainTnf , Tnfrsf1a
Pancreatic AdenocarcinomaPik3ca
Pancreatic NeoplasmsAtm , Nfkbia , Rela , Tnf
PancreatitisIkbkb , Nod2
Pancreatitis, Acute NecrotizingNfkbia , Rela
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Tnf
papillary renal cell carcinoma Pik3ca
Papillary Renal Cell Carcinoma, SporadicPik3ca
ParacoccidioidomycosisTnf
Parkinson DiseaseAtm , Tnf
Parkinsonian DisordersNfkb2 , Rela , Src , Tnf
Pediatric Crohn's DiseaseTnf
Pemphigoid, Benign Mucous MembraneTnf
Penile NeoplasmsPik3ca
Periodic Fever, Familial, Autosomal DominantTnfrsf1a
PeriodontitisTnf
Peripheral Nerve InjuriesTnf
PeritonitisTnf
PFAPA SyndromeNod2
Picornaviridae InfectionsTnf
Pituitary NeoplasmsPrkca
Placenta DiseasesTnf
PlasmacytomaTnf
Pleural EffusionTnf
PleurisyTnf
PneumoniaIkbkb , Tnf , Tnfrsf1a
Pneumonia, AspirationTnf
Pneumonia, BacterialChuk , Irf1 , Nod2 , Tnf , Tnfrsf1a
Pneumonia, MycoplasmaTnf
Pneumonia, PneumococcalTnf
Pneumonia, StaphylococcalNod2
Pneumonia, ViralTnf
Polychondritis, RelapsingTnf
Polycystic Kidney, Autosomal RecessivePik3ca , Src
Polycystic Ovary SyndromeTab1
POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCYRbck1
PolymyositisTnf , Tnfrsf1a
PolyuriaPrkca
Pre-EclampsiaTnf
Precancerous ConditionsAtm , Nfkbia
Precursor Cell Lymphoblastic Leukemia-LymphomaBcl10
Precursor T-Cell Lymphoblastic Leukemia-LymphomaBcl10
Prediabetic StateRelb
Pregnancy Complications, CardiovascularTnf
Prenatal Exposure Delayed EffectsAtm
Prostatic HyperplasiaRela
Prostatic Intraepithelial NeoplasiaAtm , Rela
Prostatic NeoplasmsAtm , Chuk , Map3k7 , Pik3ca , Pik3r1 , Prkca , Rela , Src , Tnf
PseudohypoaldosteronismTnfrsf1a
Pseudomonas InfectionsTnf , Tnfrsf1a
PsoriasisIkbkb , Nfkbia , Rel , Tnf , Tnfrsf1a
Pulmonary Disease, Chronic ObstructiveNod2 , Tnf , Tnfrsf1a
Pulmonary EdemaTnf
Pulmonary EmphysemaNfkbia , Tnf
Pulmonary FibrosisTnf
Pulmonary Heart DiseaseTnf
Radiation Injuries, ExperimentalTnf
Radiation PneumonitisTnf , Tnfrsf1a
RadiculopathyTnf
Rectal NeoplasmsPik3ca
Renal FibrosisTnfrsf1a
Reperfusion InjuryIrf1 , Nod2 , Pik3r1 , Prkca , Rela , Src , Tnf , Tnfrsf1a
Respiratory Distress Syndrome, AdultTnf , Tnfrsf1a
Respiratory HypersensitivityTnf
Respiratory Syncytial Virus InfectionsIrf1 , Tnf
Respiratory Tract DiseasesTnf
Respiratory Tract InfectionsIrf1 , Tnf
Retina Reperfusion InjuryTnf
Retinal Artery OcclusionTnf
Retinal DetachmentTnf , Tnfrsf1a
Retinal DiseasesTnf
RhinitisNod2 , Tnf
Rhinitis, AllergicNod2
Rhinitis, Allergic, SeasonalNod2
RhinosinusitisTnf
Sarcoidosis, Early-OnsetNod2
Sarcoidosis, PulmonaryTnf
SarcomaPik3ca , Tnf
SarcopeniaNfkbia
SchizophreniaTnf , Xpo1
Schizophrenia, ChildhoodRela
Sciatic NeuropathyNfkbia , Ran , Tnf , Tnfrsf1a
ScleritisTnf
Scleroderma, LocalizedTnf
SeizuresTnf , Tnfrsf1a
SepsisNod2 , Rela , Tnf
Septic PeritonitisPik3r1
Sezary SyndromeBcl10
ShockTnf
Shock, HemorrhagicRela , Tnf
Shock, SepticTnf
SHORT SyndromePik3r1
SilicosisTnf , Tnfrsf1a
Sjogren's SyndromeTnf
Skin AbnormalitiesChuk
Skin DiseasesTnf
Skin NeoplasmsCsnk2a1 , Csnk2a2 , Csnk2b , Cyld , Rela
Sleep Apnea, ObstructiveRela , Tnf , Tnfrsf1a
Small Cell Lung CarcinomaPik3ca
Smith-Magenis SyndromeMap3k14 , Prkca
Soft Tissue NeoplasmsTnf
Spastic Paraplegia 7, Autosomal RecessiveAtm
Spastic Paraplegia Type 7Atm
Spinal Cord CompressionTnf , Tnfrsf1a
Spinal Cord InjuriesAtm , Irf1 , Nfkbia , Rela , Tnf , Tnfrsf1a
SplenomegalyNod2
Squamous Cell Carcinoma of the LungPik3ca
Status EpilepticusAtm , Rela , Src , Tnf
Stevens-Johnson SyndromeCul1 , Rbx1 , Tnf
Stomach NeoplasmsAtm , Birc2 , Irf1 , Nod2 , Pik3ca , Tnf
Stomach UlcerTnf
StrokeIrf1 , Src , Tnf
Subarachnoid HemorrhageTnf
Systemic CandidiasisTnf
TachycardiaTnf
Telangiectasia, Hereditary HemorrhagicTnf
Temporomandibular Joint DisordersTnf
Testicular Germ Cell TumorBcl10
ThalassemiaTnf
ThrombocytopeniaTnf
THROMBOCYTOPENIA 6Src
ThrombosisTnf
ThymomaCyld
Thyroid NeoplasmsTnf
Thyroiditis, AutoimmuneTnf
Tongue NeoplasmsTnf
Toxoplasmosis, OcularNod2
TrachomaTnf
Transplant RejectionIkbkb , Nfkbia , Relb , Tnf
TrichinellosisTnf
Trichoepithelioma, Multiple Familial, 2Cyld
Trigeminal NeuralgiaTnf
TuberculosisTnf
Tuberculosis, MeningealTnf
Tuberculosis, PulmonaryIrf1 , Nod2 , Tnf
Tumor Predisposition SyndromeAtm
Ureteral ObstructionIrf1 , Relb , Tnf , Tnfrsf1a
Urinary Bladder NeoplasmsAtm , Prkca , Rela , Src , Tnf
UrticariaTnf
Uterine Cervical NeoplasmsBirc2 , Pik3ca , Rela , Tnf
Uterine NeoplasmsPik3ca , Pik3r1 , Xpo1
UveitisNod2 , Rela , Tnf , Tnfrsf1a
Uveitis, AnteriorTnf
Uveitis, IntermediateTnf
Uveomeningoencephalitic SyndromeTnf
Uveoretinitis, Autoimmune, ExperimentalTnfrsf1a
Vascular DiseasesTnf
Vascular MalformationsPik3ca
Vascular System InjuriesTnf
Venous ThromboembolismTnf
Ventilator-Induced Lung InjuryNfkbia
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftAtm
VitiligoTnf
Vulvar VestibulitisTnf
Weight GainPik3ca , Tnf
Weill-Marchesani SyndromeTnf
Wounds and InjuriesTnf
Wounds, PenetratingTnf
Pathway Annotations Associated with Genes in the nuclear factor kappa B signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
adenosine signaling pathwayChuk , Ikbkb , Nfkb1 , Nfkb2 , Nfkbia , Pik3ca
aldosterone signaling pathwayPik3ca , Pik3r1 , Prkca
allograft rejection pathwayTnf
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered Reelin signaling pathwaySrc
altered ubiquitin/proteasome degradation pathwayUbe2d3
Alzheimer disease pathwayTnf , Tnfrsf1a , Ube2d3
amyotrophic lateral sclerosis disease pathwayMapk14 , Tnf , Tnfrsf1a
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAtm , Birc2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
asthma disease pathwayTnf
ataxia telangiectasia-mutated (ATM) signaling pathwayAtm
B cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Malt1 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Syk
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2
calcium/calcium-mediated signaling pathwayPrkca
cell cycle pathway, mitoticAtm , Cul1 , Rbx1 , Skp1
ceramide signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
chemokine mediated signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
colorectal cancer pathwayPik3ca , Pik3r1
corticotropin-releasing hormone signaling pathwayArrb2
CRM1 export pathwayRan , Xpo1
cytokine mediated signaling pathwayTnf , Tnfrsf1a
dilated cardiomyopathy pathwayTnf
dopamine signaling pathwaySrc
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayArrb2 , Lck , Mapk14 , Prkca , Src , Syk
endocytosis pathwayArrb2 , Src , Traf6
endometrial cancer pathwayPik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayCul1 , Rbx1 , Skp1 , Ube2d3
endothelin signaling pathwayMapk14 , Prkca , Src
Entamoeba histolyca infection pathwayNfkb1 , Pik3ca , Pik3r1 , Prkca , Rela , Tnf
ephrin - ephrin receptor bidirectional signaling axisLck , Map3k7 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayPik3ca , Pik3r1 , Prkca , Src
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayMapk14 , Nfkb1 , Pik3r1
estrogen signaling pathwaySrc
FasL mediated signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Mapk14 , Pik3ca , Pik3r1 , Src , Syk
Fc epsilon receptor mediated signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Syk , Tnf
Fc gamma receptor mediated signaling pathwayPik3ca , Pik3r1 , Prkca , Syk
fibroblast growth factor signaling pathwayPik3ca , Pik3r1 , Src
glioma pathwayPik3ca , Pik3r1 , Prkca
glutamate signaling pathwayPrkca
glypican signaling pathwayLck , Src
gonadotropin-releasing hormone signaling pathwayMapk14 , Prkca , Src
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1 , Syk
Hedgehog signaling pathwayArrb2 , Btrc , Pik3ca , Pik3r1 , Sspo , Xpo1
hepatitis C virus infection pathwayChuk , Ikbkb , Ikbkg , Irf1 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
homologous recombination pathway of double-strand break repairAtm
hypertrophic cardiomyopathy pathwayTnf
hypoxia inducible factor pathwayRbx1
influenza A virus infection pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a , Xpo1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca
insulin-like growth factor signaling pathwayPik3ca , Pik3r1
integrin mediated signaling pathwaySharpin
interleukin-1 signaling pathwayChuk , Erc1 , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Traf6
interleukin-12 signaling pathwayLck , Mapk14 , Nfkb1 , Nfkb2 , Rela , Relb , Ripk2
interleukin-2 signaling pathwayLck , Mapk14 , Pik3ca , Pik3r1 , Syk
interleukin-23 signaling pathwayNfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf
interleukin-27 signaling pathwayTnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayMapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayIrf1 , Mapk14 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayIrf1 , Pik3ca , Pik3r1
kinin signaling pathwayArrb2
Leishmania infection pathwayMap3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
long term depressionPrkca
long term potentiationPrkca
measles infection pathwayChuk , Csnk2a1 , Csnk2a2 , Csnk2b , Map3k7 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Traf6
melanoma pathwayPik3ca , Pik3r1
microRNA pathwayRan
mitochondrial autophagy pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Src
mitogen activated protein kinase signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Prkca , Rela , Tnf , Tnfrsf1a , Traf6
mTOR signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca , Sspo
Mycobacterium tuberculosis infection pathwayBcl10 , Malt1 , Mapk14 , Nfkb1 , Nod2 , Rela , Ripk2 , Src , Syk , Tnf , Tnfrsf1a , Traf6
N-cadherin signaling pathwayPik3ca , Pik3r1
neddylation pathwayCul1 , Rbx1
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Ripk2 , Traf6
NOD-like receptor signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nod2 , Rela , Ripk2 , Tnf , Traf6
non-small cell lung cancer pathwayPik3ca , Pik3r1 , Prkca
Notch signaling pathwayCul1 , Skp1 , Sspo
nuclear factor kappa B signaling pathwayArrb2 , Atm , Bcl10 , Bcl3 , Birc2 , Btrc , Chuk , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Cyld , Erc1 , Ikbkb , Ikbkg , Irf1 , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Nfkbia , Nfkbib , Nfkbie , Nod2 , Pik3ca , Pik3r1 , Prkca , Ran , Rbck1 , Rbx1 , Rel , Rela , Relb , Ripk2 , Rnf31 , Sharpin , Skp1 , Src , Sspo , Syk , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a , Traf6 , Ube2d3 , Xpo1
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Cul1 , Ikbkb , Rbx1 , Skp1
nucleotide excision repair pathwayRbx1
p38 MAPK signaling pathwayAtm , Irf1 , Map3k7 , Mapk14 , Tab1 , Tab2 , Traf6
p53 signaling pathwayAtm , Mapk14
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayLck , Pik3ca , Pik3r1 , Src , Syk
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1 , Prkca
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3r1 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3r1
Plasmodium infection pathwayTnf
platelet-derived growth factor signaling pathwayCsnk2a1 , Lck , Pik3ca , Pik3r1 , Prkca , Src
primary immunodeficiency disease pathwayIkbkg , Lck
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1 , Rbx1
protein kinase C (PKC) signaling pathwayLck , Prkca
Reelin signaling pathwayPik3ca , Pik3r1 , Src
renal cell cancer pathwayPik3ca , Pik3r1 , Rbx1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
rheumatoid arthritis disease pathwayTnf
ribosome biogenesis pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Ran , Xpo1
RNA transport pathwayRan , Xpo1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Traf6
somatostatin signaling pathwaySrc
sphingosine 1-phosphate signaling pathwayMapk14 , Src
syndecan signaling pathwayPrkca , Src
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Tnf
Toll-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Tnf , Traf6
Toxoplasma gondii infection pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayCul1 , Rbx1 , Skp1 , Tnf
Trypanosoma brucei infection pathwayPrkca , Tnf
Trypanosoma cruzi infection pathwayChuk , Ikbkb , Ikbkg , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
tumor necrosis factor mediated signaling pathwayBirc2 , Chuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rbck1 , Rela , Rnf31 , Sharpin , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a
type 1 diabetes mellitus pathwayTnf
type 2 diabetes mellitus pathwayIkbkb , Pik3ca , Pik3r1 , Tnf
type II interferon signaling pathwayIrf1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayBirc2 , Btrc , Cul1 , Rbx1 , Skp1 , Src , Traf6 , Ube2d3
vascular endothelial growth factor signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Src
visual phototransduction pathwayArrb2
Wnt signaling pathwayBtrc , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Map3k7 , Prkca , Rbx1 , Skp1
Wnt signaling, canonical pathwayBtrc
Wnt signaling, non-canonical pathwayArrb2 , Map3k7 , Tab1 , Tab2
Phenotype Annotations Associated with Genes in the nuclear factor kappa B signaling pathway

References Associated with the nuclear factor kappa B signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: