ANGIOTENSIN II SIGNALING PATHWAY VIA AT1 RECEPTOR (PW:0000527)

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Description

Agiotensin II (AgtII) is probably the most potent of the biologically active peptides generated by the renin-angiotensin system pathway. Overall AgtII elicits distinct responses through signaling via receptor type 1 and 2, Agtr1 and Agtr2, respectively. Of the two receptors, Agtr1, which is expressed in most tissues and which in rodents is represented by two genes that are 95% identical in their amino acid sequences, is the better understood system. The Agtr1 mediated pathway is involved in vas

Pathway Diagram:

Elsevier Inc. Ca2+ calcium/calcium-mediated signaling pathway protein kinase C (PKC) signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway protein kinase C (PKC) signaling pathway IP3 DAG Gna11 Gnaq G protein mediated signaling pathway via Galphaq family epidermal growth factor/neuregulin signaling pathway EGF transactivation Jak2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway receptor internalization calcium transport pathway renin-angiotensin system signaling pathway Jak-Stat signaling pathway receptor recycling Agtr1 ---- Arrb2 Agtr1 ---- Gnaq Agtr1 ---- Gna11 Agtr1 ---- Jak2 Agtr1b ---- Gnaq Agtr1 ---- Agtrap Agtr1 ---- Arrb1 Agtr1 ---- Arap1 GRK members ---> Agtr1 Agt Agt ---> AgtII AgtII ---- Agtr1 Agtr1b AgtII ---- Agtr1b Agtr1b ---- Gna11 GRK members Arap1 Agtrap ---| Agtr1 Agtr1 Arap1 --+> Agtr1 Rgs2 ---| Gna11 Rgs2 ---| Gnaq Gnaq --+> DAG DAG --+> protein kinase C (PKC) signaling pathway protein kinase C (PKC) signaling pathway ---> epidermal growth factor/neuregulin signaling pathway Rgs2 Arrb2 Arrb1 Agtrap Gnaq --+> IP3 Ca2+ --+> protein kinase C (PKC) signaling pathway IP3 --+> Ca2+ AgtII ---> vasoconstriction vasoconstriction hormone release cell proliferation AgtII ---> cell proliferation AgtII kidney function AgtII ---> kidney function AgtII ---> hormone release
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Genes in Pathway:

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angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
RGD:2316188
RGD:5133683
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
RGD:6478796
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin pathway
Functional ClassGRKG-protein coupled receptor kinase members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor
Disease TermsGene Symbols
Abortion, SpontaneousAgtr1a , Jak2
AIDS-Associated NephropathyAgtr1a
AlbuminuriaAgt , Gnaq
AlkalosisAgt
Allanson Pantzar McLeod SyndromeAgt , Agtr1a
Alzheimer DiseaseAgt , Agtr1a , Grk5 , Jak2
Amphetamine-Related DisordersArrb2
AnaphylaxisAgt
AnemiaAgt , Jak2
Aneurysm, DissectingAgt
Angina, UnstableAgt , Agtr1a
Anti-Glomerular Basement Membrane DiseaseAgt , Agtr1a
AnuriaAgt
Aortic AneurysmAgt
Aortic Aneurysm, AbdominalAgt , Agtr1a
Aortic CalcificationAgt
Arrhythmias, CardiacAgt , Agtr1a
Arteriovenous FistulaArrb1 , Arrb2
Arthritis, ExperimentalArrb1 , Arrb2 , Jak2
Arthritis, RheumatoidGrk2 , Grk5 , Grk6 , Jak2 , Tyk2
AsthmaAgtr1a
AtherosclerosisAgt
Atrial FibrillationAgt , Agtr1a
Bipolar DisorderAgt , Grk3
Blood Coagulation DisordersGnaq
BradycardiaAgt
Brain InjuriesJak2
Breast NeoplasmsAgt , Agtr1a , Rgs2
Budd-Chiari SyndromeJak2
CalcinosisJak2
Capillary Malformations, CongenitalGnaq
Capillary Malformations, Congenital, 1Gnaq
Carcinoma, Pancreatic DuctalAgtr1a
Carcinoma, Renal CellAgtr1a
CardiomegalyAgt , Agtr1a , Agtr1b , Agtrap , Gnaq , Grk2 , Grk3
CardiomyopathiesAgt , Grk2
Cardiomyopathy, AlcoholicAgt
Cardiomyopathy, DilatedAgt , Agtr1a , Gnaq
Cardiomyopathy, HypertrophicAgt
Cardiovascular AbnormalitiesAgt
Cardiovascular DiseasesAgt , Grk2 , Grk5
Carotid Artery DiseasesAgt , Agtr1a
Carotid Artery InjuriesAgtr1a
CatalepsyAgt
Cerebrovascular DisordersAgt , Agtr1a
CholestasisAgt
Chronic Intermittent HypoxiaAgt
Cocaine-Related DisordersTyk2
Cognition DisordersAgt
ColitisArrb1
Congenital AbnormalitiesGrk2
Corneal NeovascularizationAgt , Agtr1a
Coronary Artery DiseaseAgt , Agtr1a
Coronary DiseaseAgtr1a
Craniofacial AbnormalitiesGnaq
Crohn DiseaseAgt , Jak2 , Tyk2
Death, SuddenAgt
Dermatitis, Allergic ContactGrk2
Diabetes Mellitus, ExperimentalAgt
Diabetes Mellitus, Type 2Agt
Diabetic NephropathiesAgt , Agtr1a , Jak2
Diabetic RetinopathyAgt , Agtr1a
Drug OverdoseAgt
Ductus Arteriosus, PatentAgtr1a
Dyskinesia, Drug-InducedGrk6
Embryo LossGrk2
Encephalomyelitis, Autoimmune, ExperimentalJak2
Endomyocardial FibrosisAgt
Epilepsy, Temporal LobeAgt
Erectile DysfunctionAgt
Erythrocytosis, Familial, 1Jak2
Erythrocytosis, Familial, 2Jak2
Fatty LiverJak2
Fetal Growth RetardationAgt , Agtr1a
FibrosisAgt , Agtr1a
GlomerulonephritisAgt
Glomerulonephritis, IGAAgt , Agtr1a
GlomerulosclerosisAgtr1a
Glomerulosclerosis, Focal SegmentalAgt , Agtr1a , Gnaq
Glucose IntoleranceJak2
Growth DisordersJak2
Heart Defects, CongenitalGna11 , Gnaq
Heart DiseasesAgt , Jak2
Heart FailureAgt , Agtr1a , Arrb1 , Grk2
Heart Valve DiseasesJak2
HemorrhageAgt
Hepatitis, AlcoholicAgt
Hernia, DiaphragmaticAgt , Agtr1b
Huntington DiseaseAgtr1a
HydronephrosisAgt
HyperaldosteronismAgtr1b
HyperalgesiaAgt , Jak2
HyperemiaAgt
HyperglycemiaGrk2
HyperinsulinismAgt , Agtr1a
HypersensitivityAgt
HypertensionAgt , Agtr1a , Agtr1b , Agtrap , Grk2 , Rgs2
Hypertension, EssentialAgt , Agtr1a
Hypertension, MalignantAgt
Hypertension, PortalGrk2
Hypertension, Pregnancy-InducedAgt
Hypertension, PulmonaryAgt , Agtr1a
Hypertension, RenalAgt , Agtr1a
Hypertension, RenovascularAgtr1a , Agtr1b
Hypertensive NephropathyAgt , Agtr1a
HypertrophyAgt
Hypertrophy, Left VentricularAgt , Agtr1a , Grk2
HyperuricemiaJak2
Hypocalcemia, Autosomal Dominant 2Gna11
Hypocalciuric Hypercalcemia, Familial, Type 2Gna11
HypokalemiaAgt
HypotensionAgt
HypothyroidismGrk3
Infarction, Middle Cerebral ArteryAgt
InflammationAgt , Agtr1a , Grk5 , Jak2
Inflammatory Bowel Disease 11Jak2
Inflammatory Bowel DiseasesAgt
Insulin ResistanceGrk2
Intestinal Reperfusion InjuryJak2
Ischemic Attack, TransientAgt , Jak2
Kidney DiseasesAgt , Agtr1a
Kidney Failure, ChronicAgt
LeukemiaJak2
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAgt , Jak2
Leukemia, Myeloid, AcuteJak2 , Rgs2
Liver CirrhosisAgt , Arrb1
Liver Cirrhosis, AlcoholicJak2
Liver Cirrhosis, BiliaryAgt , Jak2 , Tyk2
Liver Cirrhosis, ExperimentalAgt , Agtr1a , Arrb2 , Grk2 , Jak2 , Rgs2
Liver DiseasesGrk5
Liver InjuryJak2
Liver Neoplasms, ExperimentalArrb2
Liver Reperfusion InjuryJak2
Lung DiseasesAgtr1a
Lung Diseases, ObstructiveGrk5
Lupus Erythematosus, SystemicJak2
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesJak2
Mammary Neoplasms, ExperimentalAgt , Agtr1a
Meconium Aspiration SyndromeAgt
MelanomaGna11 , Gnaq
Melanoma, Cutaneous MalignantAgt
Mesenteric Vascular OcclusionJak2
Metabolic Syndrome XAgt , Agtr1a
Mitral Valve ProlapseAgt
Multiple SclerosisTyk2
Mycobacterium Infections, NontuberculousTyk2
Myeloproliferative DisordersJak2
Myocardial InfarctionAgt , Agtr1a , Jak2
Myocardial IschemiaAgt , Jak2
Myocardial Reperfusion InjuryAgt , Agtr1a , Jak2
NecrosisAgt
NeointimaAgt
Neoplasm MetastasisAgtr1a
NephritisAgtr1a
NephrosisAgt
Nephrosis, Puromycin AminonucleosideAgt
Nephrotic SyndromeJak2
Nevi Flammei, Familial MultipleGnaq
Niemann-Pick Disease, Type CJak2
Non-alcoholic Fatty Liver DiseaseJak2
ObesityAgt , Jak2
ocular melanomaGna11 , Gnaq
OtosclerosisAgt
Paranoid DisordersTyk2
Parkinson DiseaseAgtr1a , Grk2 , Grk3 , Grk5 , Grk6
Parkinson Disease, SecondaryRgs2
Peptic Ulcer HemorrhageAgt
Pituitary NeoplasmsAgtr1a
Placental InsufficiencyAgtr1a
PolycythemiaJak2
Polycythemia VeraJak2
Port-Wine StainGnaq
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
Pre-EclampsiaAgt
Precursor T-Cell Lymphoblastic Leukemia-LymphomaTyk2
Prediabetic StateAgt
Pregnancy ComplicationsJak2
Prenatal Exposure Delayed EffectsAgtr1b
Primary MyelofibrosisJak2
Prostatic NeoplasmsJak2
ProteinuriaAgt , Agtr1a
PsoriasisTyk2
Pulmonary EdemaAgt
Pulmonary FibrosisAgt , Agtr1a
Purpura, Schoenlein-HenochAgt
Radiation Injuries, ExperimentalAgtr1a
Renal InsufficiencyAgt
Renal Insufficiency, ChronicAgtr1a
Renal Tubular DysgenesisAgt , Agtr1a
Reperfusion InjuryAgt , Jak2
Retinal DetachmentJak2
Retinal VasculitisAgt
Retinopathy of PrematurityAgt
SarcoidosisAgtr1a
Sciatic NeuropathyAgt
Scleroderma, DiffuseAgt
Scleroderma, LimitedJak2
Scleroderma, SystemicAgt
ScrapieJak2
SeizuresAgt
SepsisGrk2 , Grk5 , Jak2
Sepsis-Associated EncephalopathyJak2
Sick Sinus SyndromeAgt
Spinal Cord InjuriesJak2
Spondylitis, AnkylosingJak2
Stomach NeoplasmsRgs2
Stomach UlcerAgt
StrokeAgt , Jak2
Sturge-Weber SyndromeGnaq
Temporomandibular Joint DisordersGrk5
Thrombocythemia 3Jak2
Thrombocythemia, EssentialJak2
ThrombocytosisJak2
ThromboembolismJak2
ThrombosisAgt
Tyrosine Kinase 2 DeficiencyTyk2
Ureteral ObstructionAgt
Uterine Cervical NeoplasmsJak2
Uveal MelanomaGna11 , Gnaq
Vascular RemodelingAgt
Venous ThrombosisJak2
Ventricular Dysfunction, LeftAgt
Ventricular RemodelingAgtr1a
Vesico-Ureteral RefluxAgtr1a
Water-Electrolyte ImbalanceAgtr1b
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Grk5 , Rgs2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyGna11 , Gnaq
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
aldosterone signaling pathwayJak2
altered Jak-Stat signaling pathwayJak2
Alzheimer disease pathwayGnaq
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAgt
angiotensin II signaling pathwayAgt , Agtr1a , Agtr1b , Jak2
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b , Agtrap , Arap1 , Arrb1 , Arrb2 , Gna11 , Gnaq , Grk2 , Grk3 , Grk5 , Grk6 , Jak2 , Rgs2 , Tyk2
angiotensin II signaling pathway via AT2 receptorAgt
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAgt , Agtr1a
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b , Gna11 , Gnaq
candesartan pharmacodynamics pathwayAgt , Agtr1a
captopril pharmacodynamics pathwayAgt , Agtr1a
carvedilol pharmacodynamics pathwayAgtr1a
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Jak2
cilazapril pharmacodynamics pathwayAgt , Agtr1a
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Grk3 , Grk6
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Rgs2
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Rgs2
eicosanoid signaling pathwayArrb2 , Gna11 , Gnaq , Grk2 , Grk3
enalapril pharmacodynamics pathwayAgt , Agtr1a
endocytosis pathwayArap1 , Arrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6
endothelin signaling pathwayGna11 , Gnaq , Jak2
Entamoeba histolyca infection pathwayGna11 , Gnaq
epinephrine signaling pathway via adrenergic receptor betaArrb1 , Arrb2 , Grk2 , Grk5
eprosartan pharmacodynamics pathwayAgt , Agtr1a
erythropoietin signaling pathwayJak2
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAgt , Agtr1a
fosinopril pharmacodynamics pathwayAgt , Agtr1a
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyRgs2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b , Gna11 , Gnaq , Rgs2
G protein mediated signaling pathway via Galphas familyGrk2 , Grk3 , Rgs2
glutamate signaling pathwayGnaq , Grk2 , Grk3
gonadotropin-releasing hormone signaling pathwayGna11 , Gnaq
granulocyte-macrophage colony-stimulating factor signaling pathwayJak2
growth hormone signaling pathwayJak2
Hedgehog signaling pathwayArrb2 , Grk2
Huntington disease pathwayGnaq
ibutilide pharmacodynamics pathwayAgtr1a
influenza A virus infection pathwayJak2
Interleukin-10 signaling pathwayTyk2
interleukin-12 signaling pathwayJak2 , Tyk2
interleukin-23 signaling pathwayJak2 , Tyk2
interleukin-27 signaling pathwayJak2 , Tyk2
interleukin-3 signaling pathwayJak2
interleukin-4 signaling pathwayJak2
interleukin-5 signaling pathwayJak2
interleukin-6 signaling pathwayJak2 , Tyk2
irbesartan pharmacodynamics pathwayAgt , Agtr1a
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
Jak-Stat signaling pathwayJak2 , Tyk2
kinin signaling pathwayArrb1 , Arrb2
Leishmania infection pathwayJak2
leptin system pathwayJak2
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAgt , Agtr1a
long term depressionGna11 , Gnaq
long term potentiationAgt , Gnaq
losartan pharmacodynamics pathwayAgt , Agtr1a
measles infection pathwayJak2
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2
moexipril pharmacodynamics pathwayAgt , Agtr1a
Mycobacterium tuberculosis infection pathwayJak2
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
Non-Stat, Jak dependent pathwayTyk2
nuclear factor kappa B signaling pathwayArrb2
olmesartan pharmacodynamics pathwayAgt , Agtr1a
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxytocin signaling pathwayGna11 , Gnaq
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAgt , Agtr1a
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
platelet-derived growth factor signaling pathwayArap1 , Jak2
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAgt , Agtr1a
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAgt , Agtr1a
renin-angiotensin cascade pathwayAgt , Agtr1a , Agtr1b
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAgtr1a
sphingosine 1-phosphate signaling pathwayGna11 , Gnaq , Jak2
spirapril pharmacodynamics pathwayAgt , Agtr1a
telmisartan pharmacodynamics pathwayAgt , Agtr1a
timolol pharmacodynamics pathwayAgtr1a
Toxoplasma gondii infection pathwayJak2
trandolapril pharmacodynamics pathwayAgt , Agtr1a
transforming growth factor-beta Smad dependent signaling pathwayArrb2
Trypanosoma brucei infection pathwayGnaq
Trypanosoma cruzi infection pathwayGna11 , Gnaq
type II interferon signaling pathwayJak2
valsartan pharmacodynamics pathwayAgt , Agtr1a
vasopressin signaling pathwayGna11 , Gnaq
vasopressin signaling pathway via receptor type 1Gna11 , Gnaq
verapamil pharmacodynamics pathwayAgtr1a
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling, non-canonical pathwayArrb2
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor
Phenotype TermsGene Symbols
cardiac hypertrophyAgtr1b

References Associated with the angiotensin II signaling pathway via AT1 receptor:

Ontology Path Diagram:

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