ERK5 MAPK SIGNALING PATHWAY (PW:0000603)

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Description

The Erk5 MAPK signaling pathway, also known as the big MAP kinase responds to various stresses and under certain conditions to growth factors. Erk5 displays the characteristic three-tier core cascade MAPK architecture. The only downstream and effector in the MAPK tier is Erk5 (represented by Mapk7); its activation requires phosphorylation of threonine and tyrosine residues within the conserved TEY motif in the activation loop by dual specificity kinase of the middle MAP2K tier (Mkk5 represented

Pathway Diagram:

Ariadne Genomics Inc. Map3k3 stress conditions effectors/adapters Map3k2 Sh2d2a Wnk1 nuclear target(s) Mapk7 Map2k5 RTK
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Genes in Pathway:

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Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:2298532
RGD:1582263
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:2298532
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2298532
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298532
RGD:2298794
G Sh2d2a SH2 domain containing 2A JBrowse link 2 187,218,851 187,225,000 RGD:2298532
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:2298532
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:2298532
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298532

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupRap1members of the Ras related protein 1 family

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Erk5 MAPK signaling pathway
Pathway Annotations Associated with Genes in the Erk5 MAPK signaling pathway

References Associated with the Erk5 MAPK signaling pathway:

Ontology Path Diagram:

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