PROSTATE CANCER PATHWAY (PW:0000609)

View Ontology Report

Description

Prostate neoplasm is a common form of cancer affecting about 1 in 5 men. Normal as well as malignant prostate tissues rely on the action of androgen hormones for growth and proliferation. Testosterone, the main androgen, is primarily synthesized in the testes; others are synthesized in the adrenal gland and can be converted to testosterone in peripheral tissues. In some of the target cells, testosterone can be converted to its very potent metabolite dehydrotestosterone (DHT). Testosterone and DH

Pathway Diagram:

Elsevier Inc. upregulated target translation downregulated target translation Prostatic Neoplasms altered p53 signaling pathway ---> altered expression of target genes gene fusion events ---> Prostatic Neoplasms androgen independent Ar activity ---> altered expression of target genes androgen independent Ar activity altered androgen signaling pathway ---> androgen independent Ar activity gene fusion events Tp53 altered p53 signaling pathway donwregulated miRNA altered expression of target genes upergulated miRNA Ncor2 Ncoa2 Ar altered androgen signaling pathway donwregulated miRNA ---> upregulated target translation potential PC miRNA ---> Prostatic Neoplasms upergulated miRNA ---> downregulated target translation potential PC miRNA Pten Pik3ca altered androgen signaling pathway ---> increased Ar activity increased Ar activity altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes increased Ar activity ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway altered regulation of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
prostate cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326139
RGD:8693397
RGD:6907045
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6907045
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6907045
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6907045
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6907045
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:6907045
G Creb3l2 cAMP responsive element binding protein 3-like 2 JBrowse link 4 64,869,285 64,981,519 RGD:6907045
G Creb3l3 cAMP responsive element binding protein 3-like 3 JBrowse link 7 11,490,852 11,499,287 RGD:6907045
G Creb3l4 cAMP responsive element binding protein 3-like 4 JBrowse link 2 189,596,657 189,602,243 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6907045
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:6907045
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6907045
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6907045
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:6907045
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:6907045
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6907045
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:8693397
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:8693397
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6907045
G Nkx3-1 NK3 homeobox 1 JBrowse link 15 51,065,316 51,067,908 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6907045
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6907045
G Pdgfc platelet derived growth factor C JBrowse link 2 179,952,227 180,126,897 RGD:6907045
G Pdgfd platelet derived growth factor D JBrowse link 8 4,441,010 4,666,754 RGD:6907045
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6907045
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
RGD:8693397
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2326139
RGD:8693397
RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:6907045
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045
RGD:8693397

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayaltered p53 signaling pathway
Gene Grouppotential PC miRNA
Diseaseprostatic neoplasms
Pathwayaltered androgen signaling pathway
Pathwayaltered phosphatidylinositol 3-kinase-Akt signaling pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the prostate cancer pathway
Disease TermsGene Symbols
Colitis, UlcerativeTp53
Pathway Annotations Associated with Genes in the prostate cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Chuk , Grb2 , Hras , Ikbkb , Ikbkg , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nfkb1 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Chuk , Creb1 , Hras , Ikbkb , Map2k2 , Mapk1 , Nfkb1 , Nfkbia , Pdpk1 , Pik3ca
aldosterone signaling pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Igf1 , Ins1 , Ins2 , Kras , Mapk1 , Mapk3 , Ncoa2 , Ncor2 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered androgen signaling pathwayAr , Ncoa2 , Ncor2
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin signaling pathwayIns2
altered insulin-like growth factor signaling pathwayIgf1
altered p53 signaling pathwayMdm2 , Tp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Wnt signaling, canonical pathwayCtnnb1 , Tcf7l2
Alzheimer disease pathwayBad , Casp9 , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Bcl2 , Casp9 , Tp53
androgen signaling pathwayAr , Crebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
angiotensin II signaling pathwayPdpk1
antigen processing and presentation pathwayCreb1 , Hsp90aa1 , Hsp90ab1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Casp9 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tp53
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
autophagy pathwayIns1 , Ins2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Grb2 , Gsk3b , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2
basal cell carcinoma pathwayCtnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
bladder cancer pathwayBraf , Ccnd1 , Cdkn1a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mdm2 , Nras , Raf1 , Rb1 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2 , Pdgfra , Pdgfrb
cardiovascular system disease pathwayIgf1
cell cycle pathway, mitoticCcnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Cdkn1b , Crebbp , E2f1 , E2f3 , Ep300 , Gsk3b , Mdm2 , Rb1 , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Igf1 , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pdgfa , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Tgfa , Tp53
cerium oxide nanoparticle response pathwayFgfr1
cetuximab pharmacodynamics pathwayEgfr
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Chuk , Grb2 , Gsk3b , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdkn1a , Cdkn1b , Chuk , E2f1 , E2f3 , Grb2 , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mdm2 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Sos1 , Sos2 , Tp53
codeine and morphine pharmacodynamics pathwayHsp90b1
codeine and morphine pharmacokinetics pathwayHsp90b1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
cortisol signaling pathwayCrebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
cytokine mediated signaling pathwayEgf , Egfr , Pdgfa , Pdgfra , Pdgfrb
dilated cardiomyopathy pathwayIgf1
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Ctnnb1 , Egf , Egfr , Igf1 , Igf1r , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayEgf , Egfr , Fgfr2 , Hras , Igf1r , Mdm2 , Pdgfra
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
endoplasmic reticulum stress - the unfolded protein response pathwayAtf4 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4
Endoplasmic Reticulum-associated degradation pathwayAtf4 , Bcl2 , Hsp90aa1 , Hsp90ab1 , Hsp90b1
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
Entamoeba histolyca infection pathwayNfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Cdkn1b , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayBcl2 , Grb2 , Hras , Nfkb1 , Pik3r1 , Sos1
estrogen signaling pathwayCrebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
etoposide pharmacodynamics pathwayHsp90b1
etoposide pharmacokinetics pathwayHsp90b1
FasL mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Fgfr1 , Fgfr2 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Sos1
follicle-stimulating hormone signaling pathwayCreb1
forkhead class A signaling pathwayAkt1 , Ar , Cdkn1b , Creb1 , Crebbp , Ep300 , Ins2 , Nkx3-1
G1 phase pathwayCcnd1
G1/S DNA damage checkpoint pathwayCcne1
G1/S transition pathwayCcnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Cdkn1b , Rb1
gefitinib pharmacodynamics pathwayEgfr
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdkn1a , E2f1 , E2f3 , Egf , Egfr , Grb2 , Hras , Igf1 , Igf1r , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mdm2 , Mtor , Nras , Pdgfa , Pdgfb , Pdgfra , Pdgfrb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glutathione conjugation pathwayGstp1
glutathione metabolic pathwayGstp1
glyburide pharmacodynamics pathwayIns2
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayFgfr1
gonadotropin-releasing hormone signaling pathwayAtf4 , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Chuk , Egf , Egfr , Grb2 , Gsk3b , Hras , Ikbkb , Ikbkg , Kras , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2 , Tp53
histamine signaling pathway, immunologicalCreb1
histone modification pathwayCrebbp , Ep300
Huntington disease pathwayCasp9 , Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Crebbp , Ep300 , Tp53
hypertrophic cardiomyopathy pathwayIgf1
hypoxia inducible factor pathwayAkt1 , Creb1 , Crebbp , Ep300 , Ncoa2
ibuprofen pharmacodynamics pathwayHsp90b1
ibuprofen pharmacokinetics pathwayHsp90b1
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Crebbp , Ep300 , Gsk3b , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b , Ins2
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo1 , Grb2 , Gsk3b , Hras , Ikbkb , Ins1 , Ins2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Igf1 , Igf1r , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
interleukin-12 signaling pathwayMtor , Nfkb1 , Rela
interleukin-2 signaling pathwayBcl2 , Cdk2 , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-23 signaling pathwayNfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Mtor , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Foxo1 , Grb2 , Hsp90b1 , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Bcl2 , Casp9
irinotecan pharmacodynamics pathwayHsp90b1
irinotecan pharmacokinetics pathwayHsp90b1
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Crebbp , Ep300 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmania infection pathwayMapk1 , Mapk3 , Nfkb1 , Nfkbia , Rela
long term depressionBraf , Gsk3b , Hras , Igf1 , Igf1r , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationAtf4 , Braf , Crebbp , Ep300 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
luteinizing hormone signaling pathwayCreb1
maturity onset diabetes of the young pathwayIns1 , Ins2
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1b , Chuk , Gsk3b , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdkn1a , E2f1 , E2f3 , Egf , Egfr , Fgfr1 , Hras , Igf1 , Igf1r , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mdm2 , Nras , Pdgfa , Pdgfb , Pdgfc , Pdgfd , Pdgfra , Pdgfrb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Atf4 , Braf , Chuk , Egf , Egfr , Erbb2 , Fgfr1 , Fgfr2 , Grb2 , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nras , Pdgfa , Pdgfb , Pdgfra , Pdgfrb , Raf1 , Rela , Sos1 , Sos2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Ccne1 , Cdk2 , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Casp9 , Creb1 , Crebbp , Ep300 , Mapk1 , Mapk3 , Nfkb1 , Raf1 , Rela
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayCtnnb1 , Fgfr1 , Pik3ca , Pik3r1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Atf4 , Bad , Bcl2 , Braf , Grb2 , Gsk3b , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayChuk , Hsp90aa1 , Hsp90ab1 , Hsp90b1 , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Rela
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
Notch signaling pathwayCcnd1 , Cdkn1a , Crebbp , Ep300 , Ncor2
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Crebbp , Gsk3b , Ikbkb , Pten
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Crebbp , Ep300 , Gsk3b , Igf1 , Mdm2 , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayCcne1 , Tp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Rela , Tcf7l2 , Tgfa , Tp53
panitumumab pharmacodynamics pathwayEgfr
paracetamol pharmacokinetics pathwayGstp1 , Hsp90b1
Parkinson disease pathwayCasp9
phase I biotransformation pathway via cytochrome P450Gstp1
phenytoin pharmacodynamics pathwayHsp90b1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Hsp90aa1 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Gsk3b , Hsp90aa1 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
platelet-derived growth factor signaling pathwayBraf , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdgfa , Pdgfb , Pdgfc , Pdgfd , Pdgfra , Pdgfrb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1
potassium channel inhibitors pharmacodynamics pathwayIns2
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
primary immunodeficiency disease pathwayIkbkg
prion diseases pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Ar , Atf4 , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Cdkn1b , Chuk , Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Crebbp , Ctnnb1 , E2f1 , E2f3 , Egf , Egfr , Ep300 , Erbb2 , Fgfr1 , Fgfr2 , Foxo1 , Grb2 , Gsk3b , Gstp1 , Hras , Hsp90aa1 , Hsp90ab1 , Hsp90b1 , Igf1 , Igf1r , Ikbkb , Ikbkg , Ins1 , Ins2 , Insrr , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mdm2 , Mtor , Ncoa2 , Ncor2 , Nfkb1 , Nfkbia , Nkx3-1 , Nras , Pdgfa , Pdgfb , Pdgfc , Pdgfd , Pdgfra , Pdgfrb , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Rela , Sos1 , Sos2 , Srd5a2 , Tcf3 , Tcf7 , Tcf7l2 , Tgfa , Tp53
protein kinase C (PKC) signaling pathwayHsp90aa1 , Pdpk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Crebbp , Ep300 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
retinoic acid signaling pathwayNcoa2 , Ncor2
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Rela
retinol metabolic pathwayHsp90b1
RNA polymerase I transcription pathwayCrebbp
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Pik3r1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2 , Casp9 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1b , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rb1 , Rela , Tp53
sorafenib pharmacokinetics pathwayHsp90b1
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Mapk1 , Mapk3 , Pdgfb , Pdgfrb
spinobulbar muscular atrophy disease pathwayAr
steroid hormone biosynthetic pathwaySrd5a2
syndecan signaling pathwayEgfr , Fgfr1 , Hras , Mapk1 , Mapk3
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Grb2 , Gsk3b , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2
tamoxifen pharmacodynamics pathwayNcor2
testosterone biosynthetic pathwaySrd5a2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Ctnnb1 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Tcf3 , Tcf7 , Tcf7l2 , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Casp9 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayCreb1 , Crebbp , Ctnnb1 , Foxo1 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Mapk1 , Mapk3
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
tumor necrosis factor mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
type 1 diabetes mellitus pathwayIns1 , Ins2
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Ins1 , Ins2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Crebbp , Ep300 , Map2k1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayMdm2
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnnb1 , Grb2 , Hras , Hsp90aa1 , Hsp90ab1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
vasopressin signaling pathway via receptor type 2Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4
vinblastine pharmacodynamics pathwayCdkn1a , Tp53
vincristine pharmacodynamics pathwayCdkn1a , Tp53
vindesine pharmacodynamics pathwayCdkn1a , Tp53
vinorelbine pharmacodynamics pathwayCdkn1a , Tp53
vitamin A deficiency pathwayHsp90b1
Wnt signaling pathwayCcnd1 , Crebbp , Ctnnb1 , Ep300 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Wnt signaling, canonical pathwayCrebbp , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
Phenotype Annotations Associated with Genes in the prostate cancer pathway

References Associated with the prostate cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: