MISMATCH REPAIR PATHWAY (PW:0000662)

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Description

DNA mismatch repair (MMR) represents a highly conserved pathway that assures the correct base matching of the duplex. Despite the high replication fidelity of polymerases, mismatched bases may be introduced into the daughter strand during DNA replication; small deletion/insertion loops may be introduced during replication of repetitive DNA tracts. If uncorrected, mismatches will give rise to potentially deleterious mutations. MMR pathway has been well studied and characterized in E. col

Pathway Diagram:

Ariadne Genomics Inc. Rpa complex Pcna pold complex ATP Rfc complex Msh members Mlh members Pms members Exo1 ---- Pcna Msh members ---- Pcna Mlh members ---- Pcna Pcna ---- pold complex Exo1 ---- Mlh members Exo1 ---- Msh members Lig1 ---- Pcna Pcna ---- Rfc complex Exo1 excised base Lig1
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Genes in Pathway:

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mismatch repair pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:2306716
RGD:6907045
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:2306716
G Lig1 DNA ligase 1 JBrowse link 1 75,356,212 75,394,757 RGD:2306716
RGD:6907045
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:2306716
RGD:6907045
G Mlh3 mutL homolog 3 JBrowse link 6 109,059,386 109,095,876 RGD:2306716
RGD:6907045
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:2306716
RGD:6907045
G Msh3 mutS homolog 3 JBrowse link 2 21,790,048 21,931,791 RGD:2306716
RGD:6907045
G Msh6 mutS homolog 6 JBrowse link 6 11,644,565 11,662,389 RGD:2306716
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:2306716
RGD:6907045
G Pms1 PMS1 homolog 1, mismatch repair system component JBrowse link 9 53,120,656 53,206,520 RGD:2306716
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:2306716
RGD:6907045
G Pold1 DNA polymerase delta 1, catalytic subunit JBrowse link 1 100,538,066 100,554,105 RGD:2306716
RGD:6907045
G Pold2 DNA polymerase delta 2, accessory subunit JBrowse link 14 86,111,416 86,117,578 RGD:2306716
RGD:6907045
G Pold3 DNA polymerase delta 3, accessory subunit JBrowse link 1 165,085,142 165,122,385 RGD:2306716
RGD:6907045
G Pold4 DNA polymerase delta 4, accessory subunit JBrowse link 1 219,480,841 219,483,244 RGD:2306716
RGD:6907045
G Rfc1 replication factor C subunit 1 JBrowse link 14 44,627,528 44,702,205 RGD:2306716
RGD:6907045
G Rfc2 replication factor C subunit 2 JBrowse link 12 25,130,375 25,143,480 RGD:2306716
RGD:6907045
G Rfc3 replication factor C subunit 3 JBrowse link 12 1,460,581 1,471,344 RGD:2306716
RGD:6907045
G Rfc4 replication factor C subunit 4 JBrowse link 11 81,358,592 81,373,044 RGD:2306716
RGD:6907045
G Rfc5 replication factor C subunit 5 JBrowse link 12 44,931,494 44,941,051 RGD:2306716
RGD:6907045
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:2306716
RGD:6907045
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:2306716
RGD:6907045
G Rpa3 replication protein A3 JBrowse link 4 34,279,320 34,282,351 RGD:2306716
RGD:6907045
G Ssbp1 single stranded DNA binding protein 1 JBrowse link 4 68,634,844 68,645,112 RGD:6907045
altered mismatch repair pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:2306714
RGD:4143515
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:2306714
G Msh6 mutS homolog 6 JBrowse link 6 11,644,565 11,662,389 RGD:2306714
G Pms1 PMS1 homolog 1, mismatch repair system component JBrowse link 9 53,120,656 53,206,520 RGD:2306714
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:2306714

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassMlh membersMhh gene products orthologs of MutL
Functional ClassMsh membersMsh gene products orthologs of MutS
Functional ClassPms membersPms gene products orthologs of MutL
ComplexPOLD complexpolymerase delta complex
ComplexRfc complexreplication factor C complex
ComplexRpa complexreplication protein A complex

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the mismatch repair pathway

References Associated with the mismatch repair pathway:

Ontology Path Diagram:

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