TRAIL MEDIATED SIGNALING PATHWAY (PW:0000682)

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Description

Trail mediated signaling is one of the major extrinsic apoptotic pathway engaging the death receptors. Trail, also known as Apo2L (official symbol Tnfsf10) and its receptors belong the to the tumor necrosis superfamily (TNF) of ligands and receptors. Of the five receptors that can bind Tnfsf10, only two can induce apoptosis; they both contain the DD domain (death domain) in their cytoplasmic part while the extracellular part contains the CCG (

Pathway Diagram:

Ariadne Genomics Inc. caspase targets Bid Fadd Casp3 Casp7 ---> caspase targets Casp3 ---> caspase targets Casp8 ---- Fadd Fadd ---- TNFRSF10A intrinsic apoptotic pathway Casp8 ---> Bid Fadd ---- Tnfrsf10b TNFRSF10A ---- Tnfsf10 Tnfrsf10b ---- Tnfsf10 TNFRSF10A Cflar ---- Fadd Casp8 ---> Casp3 Casp8 ---> Casp7 Casp7 ---> caspase targets Casp3 ---> caspase targets Casp7 Casp8 Cflar Tnfrsf10b Tnfsf10 Cflar ---| Casp8 Casp8 --+> Casp7 Casp8 --+> Casp3 Casp8 --+> Bid
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Genes in Pathway:

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Trail mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:4143170
RGD:4143171
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:4143170
RGD:4143171
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:4143171
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:4143170
RGD:4143171
RGD:6484113
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:4143170
RGD:4143171
RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Dap3 death associated protein 3 JBrowse link 2 188,225,607 188,255,324 RGD:6484113
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:4143170
RGD:4143171
RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6484113
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:4142856
RGD:4143170
RGD:4143171
RGD:6484113
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:2312745
RGD:4143170
RGD:4143171
RGD:6484113
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupCaspase targetstargets for caspase

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Trail mediated signaling pathway
Disease TermsGene Symbols
46,XY Sex Reversal 6Map3k1
Aberrant Crypt FociMapk1 , Mapk3
Abnormalities, MultipleChuk , Mapk1
Abortion, SpontaneousTnfsf10
Acute Lung InjuryFadd
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaCasp8 , Pik3ca , Tnfrsf10b
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungPik3ca , Tnfsf10
ADENOCARCINOMA OF STOMACHPik3ca
Adenocarcinoma, ColonMapk1 , Mapk3 , Pik3r3
Adenocarcinoma, ColorectalMapk1 , Mapk3 , Mapk8
Adenocarcinoma, ProstaticPik3ca , Pik3cb
Adenoma, ColorectalMapk8
Adrenocortical CarcinomaPik3ca
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AlopeciaTnfrsf10b
Alzheimer DiseaseCasp3 , Ikbkb , Mapk8 , Pik3r1
Amyotrophic Lateral SclerosisCasp3
AnemiaTnfrsf10b
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
AnorexiaTnfrsf10b
AnoxiaCasp3
Anti-Glomerular Basement Membrane DiseaseMapk8
Aortic Aneurysm, AbdominalMapk8
Arrhythmias, CardiacMap2k4
ArteriosclerosisTnfsf10
Arthritis, ExperimentalIkbkb , Ikbkg , Pik3cd
Arthritis, JuvenileMapk1
Arthritis, RheumatoidCasp7
AsthmaChuk
AtrophyMapk3
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autism Spectrum DisorderMapk3
Autoimmune DiseasesCasp8
Autoimmune Lymphoproliferative SyndromeCasp8
Bacterial InfectionsCasp3 , Casp8
Behcet SyndromeIkbkg
bladder urothelial carcinomaPik3ca
Bone Diseases, DevelopmentalChuk
Brain DeathMap2k4
Brain InjuriesCasp3 , Casp8 , Tnfsf10
Brain IschemiaCasp3 , Mapk1 , Mapk3 , Mapk8
Breast AdenocarcinomaPik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsCasp3 , Casp7 , Casp8 , Dap3 , Ikbkb , Map2k4 , Map3k1 , Mapk1 , Pik3ca , Pik3r1 , Tnfrsf10b , Tnfsf10
Burkitt LymphomaPik3r1
BurnsCasp3 , Tnfrsf10b
CalcinosisCasp3
Carbon Tetrachloride PoisoningFadd
CarcinomaPik3r1
Carcinoma, Adenoid CysticPik3ca
Carcinoma, Basal CellPik3ca
Carcinoma, Ductal, BreastMap2k4
Carcinoma, EndometrioidPik3r2
Carcinoma, HepatocellularBid , Casp8 , Pik3ca , Tnfsf10
Carcinoma, Non-Small-Cell LungCasp8 , Pik3ca
Carcinoma, Renal CellCasp3 , Pik3ca , Tnfrsf10b , Tnfsf10
Carcinoma, Small CellTnfsf10
Carcinoma, Squamous CellMapk1 , Mapk3 , Pik3ca , Ripk1
Carcinoma, Squamous Cell of Head and NeckCasp8 , Mapk1 , Pik3ca , Tnfrsf10b
Carcinoma, Transitional CellCasp3 , Mapk1 , Pik3ca
CardiomegalyMapk1 , Mapk8
CardiomyopathiesMapk1 , Mapk3
Cardiomyopathy, HypertrophicCasp3
Carotid Artery InjuriesCflar
Cell Transformation, NeoplasticMapk8
Cerebral HemorrhageCasp3 , Casp8
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3 , Smpd1
Choroidal NeovascularizationIkbkb
Cleft PalateChuk
Cocaine-Related DisordersMapk1 , Mapk3
Cocoon SyndromeChuk
ColitisChuk , Ikbkb
colon cancerPik3ca
Colonic NeoplasmsCasp3 , Casp7 , Ikbkb , Mapk8 , Pik3ca , Pik3r1 , Pik3r2 , Tnfrsf10b , Tnfsf10
colorectal cancerPik3ca
Colorectal NeoplasmsCasp8 , Mapk1 , Mapk3 , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Tnfsf10
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Copper-Overload CirrhosisCasp3
Coronary RestenosisMapk1
COWDEN SYNDROME 5Pik3ca
Craniofacial AbnormalitiesFadd
CryptorchidismCasp3
Currarino TriadPik3ca
DermatitisIkbkb
Dermatitis, Allergic ContactCasp8
Dermatitis, AtopicMapk8
Dermatitis, ContactCasp8
Diabetes Mellitus, ExperimentalCasp3 , Casp8 , Ikbkb , Mapk1 , Mapk3 , Pik3r1 , Smpd1 , Tnfsf10
Diabetes Mellitus, Type 1Casp3 , Casp8 , Tnfsf10
Diabetes Mellitus, Type 2Casp3 , Casp7 , Casp8 , Ikbkb , Pik3r1
Diabetic AngiopathiesCasp3
Diabetic NephropathiesCasp3 , Mapk1 , Tnfsf10
Diabetic NeuropathiesCasp3
Diabetic RetinopathyCasp3
Disease Models, AnimalMapk1 , Mapk3 , Mapk8
Drug HypersensitivityTnfrsf10b
Drug-Induced Liver InjuryCasp8 , Fadd
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EdemaCasp3 , Casp8
Encephalomyelitis, Autoimmune, ExperimentalCasp3 , Casp8
Endometrial NeoplasmsPik3ca , Tnfsf10
EndotoxemiaCasp3 , Casp7
Enterocolitis, NecrotizingIkbkg
Epidermal NevusPik3ca
Erectile DysfunctionCasp3
Esophageal NeoplasmsCasp8 , Pik3ca , Tnfrsf10b
Facial AsymmetryPik3ca
FatigueTnfrsf10b
Fatty LiverMapk8
Fetal DiseasesChuk
Fetal Growth RetardationCasp3
Gastrointestinal NeoplasmsPik3ca
Genetic Diseases, InbornMapk1 , Pik3r2
GlioblastomaPik3ca , Pik3r1 , Tnfsf10
GliomaPik3ca , Tnfsf10
GliosisMapk1 , Mapk3
GlomerulonephritisMapk1
Glucosephosphate Dehydrogenase DeficiencyIkbkg
Growth DisordersPik3ca
Hamartoma Syndrome, MultiplePik3ca
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca
Hearing Loss, SensorineuralFadd
Heart FailureCflar
Heart Valve DiseasesCasp3
HemimegalencephalyPik3ca
Hepatitis, ChronicCasp3
Hepatolenticular DegenerationSmpd1
Hodgkin DiseaseCflar
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaMapk1 , Mapk3 , Mapk8
HyperglycemiaCasp8
HyperoxiaCflar , Fadd
HyperplasiaIkbkb , Pik3ca
HypertensionCasp3 , Fadd , Ikbkb , Mapk8 , Pik3r1
Hypertension, PortalPik3r1
HypertrophyMapk1 , Mapk3
HypoglycemiaPik3r1
Hypoxia-Ischemia, BrainCasp3
Idiopathic Pulmonary FibrosisCflar
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
Immunologic Deficiency SyndromesCasp8
Incontinentia PigmentiIkbkg
Infarction, Middle Cerebral ArteryCasp3 , Fadd , Ikbkb
Infections, Recurrent, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsFadd
Infertility, FemaleMapk1 , Mapk3
InflammationChuk
Inflammatory Bowel Disease 11Casp3
Inflammatory Bowel DiseasesIkbkb
Influenza, HumanTnfsf10
Insulin ResistanceIkbkb , Pik3r1
Intermittent ClaudicationCasp3
Intestinal DiseasesCasp3
Intestinal NeoplasmsMapk8
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Irritable Bowel SyndromeIkbkg
Ischemic Attack, TransientCasp3 , Ikbkb , Map2k4
Keratosis, SeborrheicPik3ca
Kidney DiseasesMapk1
Kidney NeoplasmsMapk1 , Mapk3 , Tnfrsf10b , Tnfsf10
Kidney Reperfusion InjuryCasp3 , Ikbkb
Learning DisordersIkbkg
LeukemiaCflar , Fadd , Tnfsf10
Leukemia, Lymphocytic, Chronic, B-CellTnfrsf10b
Leukemia, Myeloid, AcuteCasp7 , Cflar , Fadd , Tnfsf10
Lichen PlanusRipk1
Limb Deformities, CongenitalChuk
Liver Cirrhosis, ExperimentalCasp7
Liver Failure, AcuteMapk8
Liver NeoplasmsCasp8 , Pik3ca , Tnfsf10
Liver Reperfusion InjuryCasp8 , Fadd , Ikbkg , Mapk8 , Tradd
lung cancerPik3ca
Lung NeoplasmsCasp7 , Casp8 , Ikbkg , Mapk1 , Mapk3 , Pik3ca
Lung Reperfusion InjuryCasp3
Lymphatic MetastasisPik3ca , Pik3cb
Lymphoma, Extranodal NK-T-CellCflar
Lymphoma, Large B-Cell, DiffusePik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellPik3cd , Tnfrsf10b
Lymphoma, Non-HodgkinPik3ca
Macular DegenerationTnfrsf10b
Malformations of Cortical DevelopmentPik3ca
Mammary Neoplasms, AnimalPik3r1
Mammary Neoplasms, ExperimentalCasp3 , Casp7 , Casp8 , Pik3r1 , Tnfrsf10b , Tnfsf10
MedulloblastomaPik3ca
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca , Pik3r2
MelanomaCasp8 , Pik3ca , Pik3r1
Melanoma, ExperimentalIkbkb
Metabolic Syndrome XFadd
Microphthalmia, Syndromic 1Map3k1
Mixed Tumor, MullerianPik3ca , Pik3r1
Morphine DependenceFadd
Mouth NeoplasmsPik3ca
Multiple MyelomaPik3ca , Tnfrsf10b
Multiple Organ FailureMapk1
Muscular AtrophyChuk , Ikbkb
Mycoplasma InfectionsCasp3
Myelodysplastic SyndromesCflar
Myocardial InfarctionCasp3 , Mapk1
Myocardial Reperfusion InjuryBid , Casp3 , Casp7 , Casp8 , Cflar , Fadd , Mapk1 , Mapk8
Nasopharyngeal CarcinomaPik3ca
Nasopharyngeal NeoplasmsPik3ca
NauseaTnfrsf10b
Nematode InfectionsPik3r1
Neoplasm InvasivenessMapk1 , Mapk3 , Smpd1
Neoplasm MetastasisCasp3 , Fadd , Mapk1 , Mapk3 , Pik3r3 , Tnfsf10
NeoplasmsPik3ca , Pik3r1 , Tnfrsf10b
Neoplasms, ExperimentalTnfsf10
Neoplastic Syndromes, HereditaryPik3ca
Neovascularization, PathologicTnfsf10
Nerve DegenerationCasp3 , Mapk1 , Mapk3
Nervous System DiseasesCasp3
NeuroblastomaPik3ca , Tnfsf10
Neurotoxicity SyndromesCasp3
NeutropeniaTnfrsf10b
Niemann-Pick Disease, Intermediate, Protracted NeurovisceralSmpd1
Niemann-Pick Disease, Type ASmpd1
Niemann-Pick Disease, Type BSmpd1
Niemann-Pick DiseasesSmpd1
Non-alcoholic Fatty Liver DiseaseIkbkg
ObesityFadd , Ikbkb , Pik3r1
Optic Nerve InjuriesTradd
OsteoarthritisTnfrsf10b , Tnfsf10
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsMap2k4 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Tnfsf10
Oxygen-Induced RetinopathyMapk8
Pancreatic AdenocarcinomaPik3ca
Pancreatic NeoplasmsBid , Casp8 , Cflar , Map2k4 , Tnfsf10
PancreatitisCasp3 , Ikbkb
Pancreatitis, Acute NecrotizingCasp3
Pancreatitis, ExperimentalIkbkg
papillary renal cell carcinoma Pik3ca
Papillary Renal Cell Carcinoma, SporadicPik3ca
PapillomaMap2k4
Papillomavirus InfectionsCasp8
Penile NeoplasmsPik3ca
Peripheral Nervous System DiseasesTnfrsf10b
Plaque, AtheroscleroticCflar
PneumoniaIkbkb
Pneumonia, BacterialChuk
Pneumonia, PneumococcalMapk1 , Mapk3
Polycystic Kidney, Autosomal RecessivePik3ca
Polycystic Ovary SyndromeTnfsf10
Precancerous ConditionsMapk8
Precursor Cell Lymphoblastic Leukemia-LymphomaCasp8
Prostatic Intraepithelial NeoplasiaMap2k4
Prostatic NeoplasmsCasp3 , Chuk , Map2k4 , Mapk3 , Pik3ca , Pik3cd , Pik3r1 , Tnfrsf10b , Tnfsf10
PsoriasisIkbkb
Pulmonary Disease, Chronic ObstructiveMap2k4 , Mapk8
Pulmonary FibrosisCflar
Radiation Injuries, ExperimentalMapk1 , Mapk3
Rectal NeoplasmsMapk8 , Pik3ca , Pik3cb
Renal FibrosisMapk1
Reperfusion InjuryBid , Casp3 , Casp7 , Casp8 , Mapk8 , Pik3r1
Retina Reperfusion InjuryMap2k4
Retinal DetachmentCasp3
Retinal DiseasesCasp3
Retinitis PigmentosaCasp7 , Ripk1
Salivary Gland DiseasesCasp3
SarcomaPik3ca
SchizophreniaMapk3 , Pik3cb
SepsisCasp3 , Casp8 , Mapk1 , Mapk3
Septic PeritonitisPik3r1
Sezary SyndromeMapk1
Shock, HemorrhagicMapk1
SHORT SyndromePik3r1
Skin AbnormalitiesChuk
Skin NeoplasmsCasp8 , Map2k4
Sleep DeprivationMap2k4
Small Cell Lung CarcinomaPik3ca
Spinal Cord InjuriesCasp3 , Fadd
Spinocerebellar AtaxiasCasp7
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungPik3ca
Status EpilepticusCasp3 , Casp8
Stomach NeoplasmsBid , Casp8 , Mapk1 , Mapk3 , Mapk8 , Pik3ca
Stomatognathic DiseasesFadd
StrokeCasp3 , Mapk8
Subarachnoid HemorrhageCasp3
Substance Withdrawal SyndromeMapk1 , Mapk3
ThrombocytopeniaTnfrsf10b
ThrombosisPik3cb
Transplant RejectionIkbkb
Trigeminal NeuralgiaMapk1 , Mapk3 , Mapk8
Urethral ObstructionMapk1
Urinary Bladder NeoplasmsCasp3 , Map2k4 , Tnfrsf10b
Urinary IncontinenceMapk1
Uterine Cervical NeoplasmsCasp3 , Casp8 , Mapk1 , Pik3ca , Tnfrsf10b
Uterine NeoplasmsPik3ca , Pik3r1
Vascular MalformationsPik3ca
VitiligoCasp7
Weight GainPik3ca
Wet Macular DegenerationMapk8
Pathway Annotations Associated with Genes in the Trail mediated signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
adenosine signaling pathwayChuk , Ikbkb , Map3k1 , Mapk1 , Mapk8 , Pik3ca
aldosterone signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
Alzheimer disease pathwayBid , Casp3 , Casp7 , Casp8 , Fadd , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBid , Casp3
apoptotic cell death pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tnfrsf10b , Tnfsf10 , Tradd , Traf2
B cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
bladder cancer pathwayMapk1 , Mapk3
Bone morphogenetic proteins signaling pathwayMapk1
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map3k1 , Mapk8 , Traf2
ceramide signaling pathwayBid , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1 , Tradd , Traf2
chemokine mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
colorectal cancer pathwayCasp3 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
cytokine mediated signaling pathwayTnfsf10
E-cadherin signaling pathwayPik3ca , Pik3r1
endometrial cancer pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Endoplasmic Reticulum-associated degradation pathwayMapk8 , Traf2
endothelin signaling pathwayMapk1 , Mapk3 , Mapk8
Entamoeba histolyca infection pathwayCasp3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
ephrin - ephrin receptor bidirectional signaling axisMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
erythropoietin signaling pathwayMapk8 , Pik3r1
extrinsic apoptotic pathwayCasp3 , Casp7 , Casp8
FasL mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1
Fc epsilon receptor mediated signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc gamma receptor mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3r1
glioma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
glutamate signaling pathwayMapk1 , Mapk3
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
glypican signaling pathwayMapk8
gonadotropin-releasing hormone signaling pathwayMap2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3r1
Hedgehog signaling pathwayPik3ca , Pik3r1
hepatitis C virus infection pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd , Traf2
Huntington disease pathwayCasp3 , Casp8
inflammatory response pathwayMapk8
influenza A virus infection pathwayIkbkb , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Tnfrsf10b , Tnfsf10
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin signaling pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
insulin-like growth factor signaling pathwayPik3ca , Pik3r1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Pik3ca , Pik3r1
interleukin-2 signaling pathwayMapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayPik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayMap2k4 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBid , Casp3 , Casp7
Jak-Stat signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Leishmania infection pathwayMapk1 , Mapk3
long term depressionMapk1 , Mapk3
long term potentiationMapk1 , Mapk3
measles infection pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Tnfrsf10b , Tnfsf10
melanoma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
mitogen activated protein kinase signaling pathwayCasp3 , Chuk , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Traf2
mTOR signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Mycobacterium tuberculosis infection pathwayBid , Casp3 , Casp8 , Fadd , Mapk1 , Mapk3 , Mapk8 , Tradd
myocarditis pathwayBid , Casp3 , Casp8
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
neurotrophic factor signaling pathwayIkbkb , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
NOD-like receptor signaling pathwayCasp8 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8
non-small cell lung cancer pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
p38 MAPK signaling pathwayMap3k1 , Traf2
p53 signaling pathwayBid , Casp3 , Casp8 , Mapk8
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Parkinson disease pathwayCasp3
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
primary immunodeficiency disease pathwayIkbkg
prion diseases pathwayMapk1 , Mapk3
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Reelin signaling pathwayMapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Ripk1 , Tradd , Traf2
Rho/Rac/Cdc42 mediated signaling pathwayMap2k4 , Mapk8
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung cancer pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Traf2
sphingolipid metabolic pathwaySmpd1
sphingosine 1-phosphate signaling pathwayMapk1 , Mapk3 , Mapk8
syndecan signaling pathwayCasp3 , Mapk1 , Mapk3 , Mapk8
T cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1 , Mapk1 , Mapk3
thyroid cancer pathwayMapk1 , Mapk3
titanium dioxide nanoparticle response pathwayCasp3 , Casp8
Toll-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd
Toxoplasma gondii infection pathwayCasp3 , Casp8 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Dap3 , Fadd , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1 , Tnfrsf10b , Tnfsf10 , Tradd , Traf2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3
Trypanosoma cruzi infection pathwayCasp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tumor necrosis factor mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Ripk1 , Smpd1 , Tradd , Traf2
type 2 diabetes mellitus pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
type II interferon signaling pathwayMap3k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayMap3k1
vascular endothelial growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Wnt signaling pathwayMapk8
Wnt signaling, non-canonical pathwayMapk8

References Associated with the Trail mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: