STEROL REGULATORY ELEMENT-BINDING PROTEIN SIGNALING PATHWAY (PW:0000753)

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Description

Sterol regulatory element-binding protein signaling pathway regulates lipid and cholesterol homeostasis via transcriptional targeting of genes such as LDL receptor and HMG-CoA reductase. HMG-CoA catalyzes the early, rate-limiting step in the cholesterol biosynthetic pathway. The sterol regulatory element binding proteins (SREBF or SREBP) represent a subfamily of basic helix-loop-helix leucine zipper transcription factors (bHLH-LZ) that have been conserved from fungi to man. In mammals, two genes

Pathway Diagram:

Ariadne Genomics Inc. translocated Srebf cholesterol Srebf targets translocated Srebf ---> fatty acid biosynthetic pathway translocated Srebf ---> cholesterol biosynthetic pathway translocated Srebf ---> Srebf targets 25-Hydroxycholesterol ---> Srebf at Golgi cholesterol ---- Scap Scap ---> Srebf at Golgi Srebf1 ---> Srebf at Golgi Srebf2 ---> Srebf at Golgi cholesterol ---> Srebf at Golgi Scap ---- Srebf1 Scap ---- Srebf2 25-Hydroxycholesterol ---- Insig2 Insig2 ---- Scap Mbtps1 ---> Srebf at Golgi Mbtps2 ---> Srebf at Golgi Mbtps1 Mbtps2 Srebf at Golgi 25-Hydroxycholesterol Insig1 Insig2 Scap Srebf2 Srebf1 fatty acid biosynthetic pathway cholesterol biosynthetic pathway Srebf at Golgi ---> translocated Srebf
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Genes in Pathway:

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sterol regulatory element-binding protein signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:2317203
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:2317203
G Mbtps1 membrane-bound transcription factor peptidase, site 1 JBrowse link 19 52,146,507 52,206,310 RGD:2317203
G Mbtps2 membrane-bound transcription factor peptidase, site 2 JBrowse link X 40,258,933 40,309,047 RGD:2317203
G Scap SREBF chaperone JBrowse link 8 118,551,869 118,628,650 RGD:2317203
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:2317203
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:2317203

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Molecule25Hch25-Hydroxycholesterol
Small Moleculecholesterolcholesterol
Gene GroupSrebf targetssterol regulatory element binding transcription factor targets

Pathway Gene Annotations

Disease Annotations Associated with Genes in the sterol regulatory element-binding protein signaling pathway
Pathway Annotations Associated with Genes in the sterol regulatory element-binding protein signaling pathway
Phenotype Annotations Associated with Genes in the sterol regulatory element-binding protein signaling pathway
Phenotype TermsGene Symbols
decreased cholesterol levelSrebf1

References Associated with the sterol regulatory element-binding protein signaling pathway:

Ontology Path Diagram:

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