CORTISOL BIOSYNTHETIC PATHWAY (PW:0000774)

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Description

Glucocorticoid hormones affect carbohydrate (e.g. gluconeogenesis), protein and lipid metabolism, and influence the inflammatory response. Cortisol, or hydrocortisone, the main C21 glucocorticoid, is primarily synthesized in the cortex of the adrenal gland. Like all steroid hormones, glucocorticoids are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis. The chronic steroidogenic response involves the change in the expression o

Pathway Diagram:

Ariadne Genomics Inc. 11-deoxycortisol ---> cortisol 17alpha-hydroxyprogesterone ---> 11-deoxycortisol pregnenolone ---> progesterone pregnenolone ---> 17-hydroxypregnenolone 17-hydroxypregnenolone ---> 17alpha-hydroxyprogesterone progesterone ---> 17alpha-hydroxyprogesterone NADPH(3) ---> NADP+(3) e e(3) Hsd3b1 Hsd3b2 progesterone 17-hydroxypregnenolone Cyp11b1 Fdx1 Fdxr NADPH(3) NADP+(3) Fdx1 ---> Cyp11a1 Fdx1 ---> Cyp11b1 NADP+ NADPH NADPH ---> e NADPH(3) ---> e(3) Cyp17a1 Por ---> Cyp17a1 Por Cyp21a1 Por ---> Cyp21a1 17alpha-hydroxyprogesterone 11-deoxycortisol cortisol Cyp11a1 NADPH ---> NADP+ cholesterol Star cholesterol ---> pregnenolone pregnenolone
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Genes in Pathway:

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cortisol biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4889549
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:4892309
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:4889549
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Molecule17 a hydroxy Pregnenolone17-alpha-Hydroxypregnenolone

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the cortisol biosynthetic pathway
Phenotype Annotations Associated with Genes in the cortisol biosynthetic pathway

References Associated with the cortisol biosynthetic pathway:

Ontology Path Diagram:

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