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Estrogen hormones are responsible for the development and maintenance of female phenotype and reproductive functions and a range of other processes in nonreproductive tissues. Estradiol, the main C18 estrogen, is primarily synthesized in the ovaries. Like all steroid hormones, estrogens are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis. The chronic steroidogenic response involves the change in the expression of steroidogen

Pathway Diagram:

Ariadne Genomics Inc. Por e Sts Sult1e1 Hsd17b1 Hsd3b2 Hsd3b1 Sts. Sult2a1 Cyp17a1 e(3) Cyp11a1 Fdx1 Fdxr cholesterol androstenediol ---> testosterone NADPH(3) ---> e(3) NADP+(3) NADPH(3) androstenediol DHEA ---> androstenedione Star NADP+ NADPH Por ---> Cyp17a1 Por ---> Cyp19a1 androstenedione testosterone NADPH(3) ---> NADP+(3) NADPH ---> e estradiol pregnenolone cholesterol ---> pregnenolone DHEA ---> DHEAS androstenedione ---> estrone testosterone ---> androstenedione estradiol ---> estrone NADPH ---> NADP+ 17-hydroxypregnenolone pregnenolone ---> 17-hydroxypregnenolone 17-hydroxypregnenolone ---> DHEA Cyp19a1 estrone ---> estrone-S estrone estrone-S ---> estrone DHEAS DHEA DHEAS ---> DHEA estrone-S Hsd17b2 estrone ---> estradiol Hsd17b3 DHEA ---> androstenediol androstenedione ---> testosterone testosterone ---> estradiol

Genes in Pathway:

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estradiol biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:4892309
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:2325883
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 JBrowse link 10 88,987,558 88,989,758 RGD:4889549
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:4889549
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6893583
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:6893583
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeDHEAdehydroepiandrosterone

Pathway Gene Annotations

Disease Annotations Associated with Genes in the estradiol biosynthetic pathway
Disease TermsGene Symbols
17,20-Lyase Deficiency, IsolatedCyp17a1
17-Hydroxysteroid Dehydrogenase DeficiencyHsd17b3
46, XY Disorders of Sex DevelopmentCyp11a1
Abortion, SpontaneousHsd17b1
Adrenal Hyperplasia 2Hsd3b2
Adrenal Hyperplasia, CongenitalCyp11a1 , Cyp17a1 , Hsd3b2 , Por , Star
Adrenal Hyperplasia, Congenital, Type 5Cyp17a1
Adrenal InsufficiencyCyp11a1
Adrenal Insufficiency, CongenitalCyp11a1
Adrenal Insufficiency, Congenital, with 46,Xy Sex ReversalCyp11a1
Alzheimer DiseaseCyp19a1 , Hsd17b3 , Hsd3b1
AmenorrheaCyp17a1 , Cyp19a1 , Por
Antley-Bixler Syndrome PhenotypePor
Antley-Bixler Syndrome with Genital Anomalies and Disordered SteroidogenesisPor
Aromatase DeficiencyCyp19a1
Arthritis, RheumatoidSts
Attention Deficit Disorder with HyperactivitySts
Autistic DisorderCyp19a1
Bone ResorptionCyp19a1
Brain InjuriesCyp11a1
Breast NeoplasmsCyp17a1 , Cyp19a1 , Hsd17b1 , Sult1e1
Carcinoma, HepatocellularCyp17a1 , Hsd3b2
CardiomegalyCyp11a1 , Star
Cell Transformation, NeoplasticPor
Chemical and Drug Induced Liver InjurySult1e1
Critical IllnessCyp19a1
CryptorchidismHsd3b2 , Sts
Diabetes Mellitus, ExperimentalCyp11a1 , Cyp19a1 , Star , Sts
Diabetes Mellitus, Type 2Cyp11a1 , Hsd17b3 , Hsd3b1 , Star
Diabetes, GestationalCyp19a1
Diabetic NephropathiesCyp19a1
Disorders of Sex DevelopmentHsd17b3
Endometrial NeoplasmsCyp11a1 , Cyp19a1 , Hsd17b2 , Star , Sult1e1
EndometriosisCyp19a1 , Hsd17b1 , Hsd17b2
Esophageal NeoplasmsCyp19a1
Fatty LiverCyp19a1 , Sts
Fetal Growth RetardationCyp11a1 , Star
Gallbladder NeoplasmsCyp17a1
HyperprolactinemiaHsd3b1 , Hsd3b2
HypertensionCyp11a1 , Cyp19a1 , Hsd3b1 , Hsd3b2 , Sts
Hypertension, MalignantCyp17a1
HypogonadismCyp11a1 , Cyp17a1 , Cyp19a1 , Hsd3b1 , Star
HypopituitarismCyp17a1 , Cyp19a1
HypospadiasHsd3b1 , Hsd3b2
HypothyroidismCyp19a1 , Hsd3b1 , Star
Ichthyosis, X-LinkedSts
Infertility, FemaleCyp17a1 , Cyp19a1
Infertility, MaleCyp17a1
Insulin ResistanceSts
Kidney Reperfusion InjuryCyp19a1
Learning DisordersPor
Lipoid Congenital Adrenal HyperplasiaCyp11a1 , Star
Liver Cirrhosis, ExperimentalCyp17a1 , Hsd17b2 , Sult1e1 , Sult2a1
Liver DiseasesSult1e1
Melanoma, Cutaneous Malignant, Susceptibility To, 1Cyp17a1
Musculoskeletal AbnormalitiesPor
Neoplasm MetastasisCyp19a1 , Sult1e1
NephrosisCyp11a1 , Star
Neural Tube DefectsPor
Non-alcoholic Fatty Liver DiseaseCyp17a1
OsteoporosisCyp17a1 , Cyp19a1
Osteoporosis, PostmenopausalCyp19a1
Ovarian CystsCyp17a1
Ovarian DiseasesCyp19a1
Ovarian NeoplasmsCyp19a1
Pancreatic NeoplasmsCyp17a1
Paranoid DisordersHsd3b2
Placental InsufficiencyCyp19a1
Pleomorphic Xanthoastrocytoma Por
Polycystic Ovary SyndromeCyp17a1 , Cyp19a1 , Hsd3b1 , Hsd3b2 , Star
Prostatic Intraepithelial NeoplasiaCyp19a1
Prostatic NeoplasmsCyp17a1 , Cyp19a1 , Hsd17b1 , Hsd17b3 , Hsd3b1 , Hsd3b2 , Sult1e1 , Sult2a1
Protein-Energy MalnutritionCyp19a1
Reperfusion InjuryCyp19a1 , Sult1e1
Sciatic NeuropathyCyp11a1 , Cyp17a1 , Hsd3b1
Sexual Dysfunctions, PsychologicalCyp17a1
Sexual InfantilismCyp19a1
Smith-Magenis SyndromeFdxr , Hsd17b1
Status EpilepticusCyp11a1
Tissue AdhesionsCyp19a1
Toe Syndactyly, Telecanthus, and Anogenital and Renal MalformationsStar
Urethral ObstructionCyp19a1
Urinary Bladder Neck ObstructionCyp19a1
Urinary Bladder NeoplasmsCyp19a1 , Por
Weight GainSts
Pathway Annotations Associated with Genes in the estradiol biosynthetic pathway

References Associated with the estradiol biosynthetic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: