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Norepinephrine and epinephrine, whose synthesis and release are prompted by various but distinct stresses, act as neurotransmitters and hormones that signal via various adrenergic receptors, G-protein coupled receptors (GPCR) that couple to distinct G alpha subunits of heterotrimeric G proteins. The beta receptors, for which epinephrine appears to be a favorite agonist, couple to the Gs alpha subunit leading to activation of adenylyl cyclases, cAMP production and subsequent triggering of PKA sig

Pathway Diagram:

Ariadne Genomics Inc. epinephrine prompting stresses epinephrine receptor internalization receptor - G protein uncoupling Gnas G protein mediated signaling pathway via Galphas family beta-arrestin mediated signaling epinephrine biosynthetic pathway protein kinase A (PKA) signaling pathway cAMP --+> protein kinase A (PKA) signaling pathway cAMP G protein mediated signaling pathway via Galphas family --+> cAMP Snx13 ---| Gnas Adrb2 ---- epinephrine Adrb1 ---- epinephrine receptor - G protein uncoupling ---| G protein mediated signaling pathway via Galphas family Grk5 ---| Adrb2 Grk5 ---| Adrb1 Adrbk1 ---| Adrb2 Adrbk1 ---| Adrb1 Grk5 Adrbk1 Snx13 Adrb2 ---- Gnas Adrb1 ---- Gnas Adrb2 ---- Arrb1 Adrb2 ---- Arrb2 Adrb1 ---- Arrb2 Adrb1 ---- Arrb1 Adrb1 Adrb2 Arrb1 Arrb2 Arrb2 ---> beta-arrestin mediated signaling Arrb1 ---> beta-arrestin mediated signaling epinephrine prompting stresses ---> epinephrine epinephrine release

Genes in Pathway:

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epinephrine signaling pathway via adrenergic receptor beta term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:4140391
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:4140391
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5135529
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5135529
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:4140391
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:4140391
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:4140391
G Snx13 sorting nexin 13 JBrowse link 6 54,487,626 54,591,716 RGD:4140388

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculecAMPcyclic AMP

Pathway Gene Annotations

Disease Annotations Associated with Genes in the epinephrine signaling pathway via adrenergic receptor beta
Disease TermsGene Symbols
Abnormalities, MultipleGnas
Acth-Independent Macronodular Adrenal HyperplasiaGnas
ACTH-Secreting Pituitary AdenomaGnas
Acute Kidney InjuryAdrb2
Adenocarcinoma of LungGnas
Adrenal Gland NeoplasmsGnas
Adrenocortical CarcinomaGnas
Albright's Hereditary OsteodystrophyGnas
Alzheimer DiseaseGnas , Grk5
Amphetamine-Related DisordersArrb2
Angina PectorisAdrb1 , Adrb2
Aortic Valve StenosisAdrb1
Arteriovenous FistulaArrb1 , Arrb2
Arthritis, ExperimentalArrb1 , Arrb2
Arthritis, RheumatoidGrk2 , Grk5
Autistic DisorderAdrb2
Birth WeightAdrb1
Body Mass Index Quantitative Trait Locus 10Adrb2
Body Mass Index Quantitative Trait Locus 11Adrb2
Body Mass Index Quantitative Trait Locus 12Adrb2
Body Mass Index Quantitative Trait Locus 14Adrb2
Body Mass Index Quantitative Trait Locus 4Adrb2
Body Mass Index Quantitative Trait Locus 7Adrb2
Body Mass Index Quantitative Trait Locus 8Adrb2
Body Mass Index Quantitative Trait Locus 9Adrb2
Bone Diseases, MetabolicGnas
breast cancerGnas
Breast NeoplasmsAdrb2 , Gnas
Cafe-au-Lait SpotsGnas
Carcinoma, HepatocellularGnas
Carcinoma, Squamous Cell of Head and NeckGnas
CardiomyopathiesAdrb2 , Grk2
Cardiomyopathy, DilatedAdrb1 , Adrb2
Cardiovascular DiseasesAdrb1 , Adrb2 , Grk2 , Grk5
CholangiocarcinomaAdrb2 , Gnas
Cognitive DysfunctionGnas
Colorectal NeoplasmsGnas
Congenital AbnormalitiesGrk2
Coronary DiseaseAdrb2
Cushing SyndromeGnas
Cystic FibrosisAdrb1 , Adrb2
Cystitis, InterstitialAdrb2
Dermatitis, Allergic ContactGrk2
Diabetes MellitusAdrb1
Diabetes Mellitus, ExperimentalAdrb1
Diabetes Mellitus, Type 1Adrb1
Diabetes Mellitus, Type 2Adrb2
Embryo LossGrk2
Endocrine System DiseasesGnas
Endomyocardial FibrosisAdrb1
Fatty LiverAdrb2
Fibrous Dysplasia, PolyostoticGnas
Genetic Diseases, InbornGnas
Glaucoma, Open-AngleAdrb2
Glaucoma, Primary Open AngleAdrb2
Graves DiseaseAdrb2
Growth Hormone-Secreting Pituitary AdenomaGnas
Heart FailureAdrb1 , Adrb2 , Arrb1 , Grk2
Hemorrhagic DisordersGnas
HyperglycemiaAdrb1 , Grk2
Hyperlipoproteinemia Type IIAdrb2
HypertensionAdrb1 , Adrb2 , Gnas , Grk2
Hypertension, PortalGrk2
Hypertension, RenovascularAdrb1
Hypertrophy, Left VentricularAdrb1 , Adrb2 , Grk2
Hypotension, OrthostaticGnas
Inflammatory Bowel Disease 11Adrb2
Insulin ResistanceAdrb2 , Gnas , Grk2
Intellectual DisabilityGnas
Kidney DiseasesAdrb2
Kidney Failure, ChronicAdrb2
Leukemia, Lymphocytic, Chronic, B-CellGnas
liver cancerGnas
Liver CirrhosisArrb1
Liver Cirrhosis, ExperimentalAdrb1 , Adrb2 , Arrb2 , Grk2
Liver DiseasesGrk5
Liver Diseases, ParasiticGnas
Liver InjuryAdrb2
Liver NeoplasmsGnas
Liver Neoplasms, ExperimentalArrb2
Low Tension GlaucomaAdrb1
Lung DiseasesAdrb2
Lung Diseases, ObstructiveGrk5
McCune Albright syndromeGnas
Metabolic DiseasesAdrb2
Metabolic Syndrome XAdrb2
Myasthenia GravisAdrb2
Myocardial InfarctionAdrb1 , Adrb2
Myocardial IschemiaAdrb1 , Adrb2
Myocardial Reperfusion InjuryAdrb1 , Adrb2
Nasal PolypsAdrb2
Nervous System DiseasesAdrb2
ObesityAdrb1 , Adrb2 , Gnas
Osseous Heteroplasia, ProgressiveGnas
Ossification, HeterotopicGnas
Pancreatic AdenocarcinomaGnas
Pancreatic NeoplasmsGnas
Parkinson DiseaseGrk2 , Grk5
Pituitary ACTH HypersecretionGnas
Pituitary NeoplasmsGnas
Pleomorphic Xanthoastrocytoma Snx13
Polycystic Ovary SyndromeAdrb2 , Gnas
Prolonged Bleeding Time, Brachydactyly, and Mental RetardationGnas
Prostatic NeoplasmsAdrb2
Pseudohypoparathyroidism Type 1AGnas
Pseudohypoparathyroidism Type 1BGnas
Pseudohypoparathyroidism Type 1CGnas
Puberty, PrecociousGnas
Pulmonary Disease, Chronic ObstructiveAdrb1 , Adrb2
Pulmonary EdemaAdrb2
Reperfusion InjuryAdrb1 , Adrb2
Respiration DisordersGnas
Sciatic NeuropathyAdrb2
SepsisAdrb2 , Grk2 , Grk5
Sex Cord-Gonadal Stromal TumorsGnas
Shock, SepticAdrb2
Sleep Apnea, ObstructiveAdrb1
Stomach NeoplasmsAdrb1 , Adrb2
Substance Withdrawal SyndromeGnas
Temporomandibular Joint DisordersGrk5
Uterine Cervical NeoplasmsGnas
Ventricular DysfunctionAdrb1
Ventricular Dysfunction, LeftAdrb2
Vestibulocochlear Nerve InjuriesAdrb2
Pathway Annotations Associated with Genes in the epinephrine signaling pathway via adrenergic receptor beta
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAdrb1
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Grk5
adenosine signaling pathwayGnas
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAdrb1 , Adrb2
amiodarone pharmacodynamics pathwayAdrb1
amlodipine pharmacodynamics pathwayAdrb1
angiotensin II signaling pathway via AT1 receptorArrb1 , Arrb2 , Grk2 , Grk5
atenolol pharmacodynamics pathwayAdrb1
betaxolol pharmacodynamics pathwayAdrb1
bile acid transport pathwayGnas
bisoprolol pharmacodynamics pathwayAdrb1
bupranolol drug pathwayAdrb1
bupranolol pharmacodynamics pathwayAdrb1
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Grk2
calcium/calcium-mediated signaling pathwayAdrb1 , Adrb2 , Gnas
carvedilol pharmacodynamics pathwayAdrb1
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk5
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Gnas
dilated cardiomyopathy pathwayAdrb1 , Gnas
diltiazem pharmacodynamics pathwayAdrb1
disopyramide pharmacodynamics pathwayAdrb1
dobutamine pharmacodynamics pathwayAdrb1
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Gnas , Grk2 , Grk5
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk5
eicosanoid signaling pathwayArrb2 , Grk2
endocytosis pathwayAdrb1 , Adrb2 , Arrb1 , Arrb2 , Grk2 , Grk5
Entamoeba histolyca infection pathwayGnas
epinephrine signaling pathway via adrenergic receptor betaAdrb1 , Adrb2 , Arrb1 , Arrb2 , Gnas , Grk2 , Grk5 , Snx13
esmolol pharmacodynamics pathwayAdrb1
flecainde pharmacodynamics pathwayAdrb1
follicle-stimulating hormone signaling pathwayGnas
fosphenytoin pharmacodynamics pathwayAdrb1
G protein mediated signaling pathway via Galphai familyAdrb2
G protein mediated signaling pathway via Galphas familyAdrb1 , Adrb2 , Gnas , Grk2 , Snx13
glucagon signaling pathwayGnas
glutamate signaling pathwayGnas , Grk2
gonadotropin-releasing hormone signaling pathwayGnas
Hedgehog signaling pathwayArrb2 , Grk2
histamine signaling pathway, immunologicalGnas
ibutilide pharmacodynamics pathwayAdrb1
isoprenaline pharmacodynamics pathwayAdrb1
isradipine pharmacodynamics pathwayAdrb1
kinin signaling pathwayArrb1 , Arrb2
levobunolol pharmacodynamics pathwayAdrb1
lidocaine pharmacodynamics pathwayAdrb1
long term depressionGnas
luteinizing hormone signaling pathwayGnas
melanocortin system pathwayGnas
metoprolol pharmacodynamics pathwayAdrb1
mexiletine pharmacodynamics pathwayAdrb1
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2
nadolol pharmacodynamics pathwayAdrb1
nebivolol pharmacodynamics pathwayAdrb1
nifedipine pharmacodynamics pathwayAdrb1
nimodipine pharmacodynamics pathwayAdrb1
nisoldipine pharmacodynamics pathwayAdrb1
nitrendipine pharmacodynamics pathwayAdrb1
nuclear factor kappa B signaling pathwayArrb2
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
penbutolol pharmacodynamics pathwayAdrb1
phenytoin pharmacodynamics pathwayAdrb1
pindolol pharmacodynamics pathwayAdrb1
procainamide pharmacodynamics pathwayAdrb1
propranolol pharmacodynamics pathwayAdrb1
prostaglandin D2 signaling pathwayGnas
prostaglandin I2 signaling pathwayGnas
quinidine pharmacodynamics pathwayAdrb1
Rho/Rac/Cdc42 mediated signaling pathwayAdrb1
serotonin signaling pathway via receptors engaging G alphas protein familyGnas
sotalol pharmacodynamics pathwayAdrb1
timolol pharmacodynamics pathwayAdrb1
transforming growth factor-beta Smad dependent signaling pathwayArrb2
Trypanosoma cruzi infection pathwayGnas
vasopressin signaling pathwayGnas
vasopressin signaling pathway via receptor type 2Gnas
verapamil pharmacodynamics pathwayAdrb1
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling, non-canonical pathwayArrb2
Phenotype Annotations Associated with Genes in the epinephrine signaling pathway via adrenergic receptor beta
Phenotype TermsGene Symbols
congestive heart failureAdrb2

References Associated with the epinephrine signaling pathway via adrenergic receptor beta:

Ontology Path Diagram:

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