RENIN-ANGIOTENSIN CASCADE PATHWAY (PW:0000492)

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Description

Renin-angiotensin system (RAS) signaling pathway is well known for its cardiovascular roles primarily via the circulating or 'classical' route and also, has become recognized as a complex system with pleiotropic effects that engages both the circulating and the local or 'tissue' routes. Originally viewed as solely endocrine, the system is now regarded as an endocrine, paracrine and autocrine one producing an array of diverse and many times opposing actions. Underlying the system's ability of pro

Pathway Diagram:

Ariadne Genomics Inc. Ren Agtr2 Agtr1a Agtr1b Mas1 Lnpep angiotensin III signaling via AT2 receptor angiotensin III signaling pathway angiotensin (1-7) signaling pathway angiotensin IV signaling pathway angiotensin II signaling pathway angiotensin II signaling via AT2 receptor angiotensin II signaling via AT1 receptor Enpep Anpep Mme Ace2 Ace renin receptor mediated intracellular signaling angiotensin IV signaling pathway ---> cognition AgtIII ---- Agtr1a Renbp ---| Ren Renbp Agt ---> AgtI AgtIII ---- Agtr2 cognition AgtII ---- Agtr1b AgtIV ---- Lnpep AgtII ---- Agtr2 AgtI ---> AgtII Igf2r ---- Ren angiotensin III signaling via AT1 receptor ---> cell proliferation vasodilation AgtII ---- Agtr1a angiotensin III signaling via AT2 receptor ---> vasodilation angiotensin II signaling via AT2 receptor ---> vasodilation Atp6ap2 ---- Ren Cma1 Atp6ap2 ---> renin receptor mediated intracellular signaling Igf2r cell proliferation vasoconstriction angiotensin II signaling via AT1 receptor ---> cell proliferation Igf2r ---> complex internalization complex internalization AgtII ---> AgtIII Agt AgtI ---> Agt(1-7) AgtIII ---> AgtIV AgtII ---> Agt(1-7) AgtIII ---- Agtr1b AgtI Agt(1-7) AgtIII AgtIV AgtII Ren ---- Renbp Ren ---> renin receptor mediated intracellular signaling angiotensin III signaling via AT1 receptor angiotensin III signaling via AT1 receptor ---> vasoconstriction angiotensin II signaling via AT1 receptor ---> vasoconstriction angiotensin (1-7) signaling pathway ---> vasodilation Atp6ap2 Agt(1-7) ---- Mas1
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Genes in Pathway:

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renin-angiotensin cascade pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
RGD:6907045
RGD:1581953
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:1581742
RGD:6907045
RGD:1581931
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581651
RGD:6907045
RGD:1582105
RGD:1581742
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581847
RGD:6907045
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581847
RGD:6907045
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581855
RGD:6907045
G Anpep alanyl aminopeptidase, membrane JBrowse link 1 141,561,364 141,604,249 RGD:1581649
RGD:6907045
G Atp6ap2 ATPase H+ transporting accessory protein 2 JBrowse link X 11,137,889 11,164,854 RGD:5132617
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581742
RGD:6907045
G Cpa3 carboxypeptidase A3 JBrowse link 2 105,016,798 105,047,989 RGD:6907045
G Ctsa cathepsin A JBrowse link 3 161,298,750 161,304,627 RGD:6907045
G Ctsg cathepsin G JBrowse link 15 35,107,333 35,113,678 RGD:6907045
G Enpep glutamyl aminopeptidase JBrowse link 2 233,667,253 233,743,866 RGD:1581649
RGD:6907045
RGD:1581742
G Igf2r insulin-like growth factor 2 receptor JBrowse link 1 48,176,095 48,264,482 RGD:1581738
RGD:1581739
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:1581849
RGD:6907045
RGD:1582105
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1581849
RGD:6907045
RGD:1581931
G Mcpt8l2 mast cell protease 8-like 2 JBrowse link 15 34,622,126 34,625,079 RGD:6907045
G Mcpt8l3 mast cell protease 8-like 3 JBrowse link 15 34,667,266 34,670,303 RGD:6907045
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1581742
RGD:6907045
RGD:1581953
RGD:1581931
G Nln neurolysin JBrowse link 2 34,086,970 34,185,835 RGD:6907045
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:1581651
RGD:6907045
RGD:1581742
RGD:1581739
RGD:1581738
G Renbp renin binding protein JBrowse link X 156,854,490 156,863,548 RGD:5132613
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:1581649
G Thop1 thimet oligopeptidase 1 JBrowse link 7 11,501,145 11,513,576 RGD:6907045
angiotensin (1-7) signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581953
RGD:1598433
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581938
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1581938
RGD:1581931
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1581742
RGD:1581931
RGD:1581953
angiotensin II signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1579760
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:629553
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1566502
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1582323
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581745
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600094
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580992
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1581775
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:12910844
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642674
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
RGD:5133683
RGD:2316188
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
RGD:6478796
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
RGD:7401256
RGD:1582435
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
RGD:7401256
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679
angiotensin III signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582124
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1582124
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1582124
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1582124
G Enpep glutamyl aminopeptidase JBrowse link 2 233,667,253 233,743,866 RGD:1581649
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582152
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1582152
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1582152
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582118
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1582118
angiotensin IV signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582105
G Anpep alanyl aminopeptidase, membrane JBrowse link 1 141,561,364 141,604,249 RGD:1581649
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:1581864
RGD:1582105
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:1581649
angiotensin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1566511

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgt(1-7)angiotensinogen derived peptide
ProteinAgtIVangiotensinogen derived peptide
ProteinAgtIIIangiotensinogen derived peptide
ProteinAgtIIangiotensinogen derived peptide

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the renin-angiotensin cascade pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
Alzheimer disease pathwayMme
amino sugar metabolic pathwayRenbp
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt , Mas1 , Mme
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b , Agtr2 , Enpep
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt , Anpep , Lnpep , Rnpep
angiotensin signaling pathwayAgt
apelin signaling pathwayAce2
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
captopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
carvedilol pharmacodynamics pathwayAgtr1a
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
enalapril pharmacokinetics pathwayAce
Entamoeba histolyca infection pathwayCtsg , Mcpt8l2 , Mcpt8l3
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
french type sialuria disease pathwayRenbp
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b
glutathione metabolic pathwayAnpep
glutathione synthase deficiency pathwayAnpep
glutathionuria disease pathwayAnpep
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
insulin responsive facilitative sugar transporter mediated glucose transport pathwayLnpep
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
kallikrein-kinin cascade pathwayAce
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
long term potentiationAgt , Lnpep
losartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
moexipril pharmacokinetics pathwayAce
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
nucleotide sugar metabolic pathwayRenbp
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Ace2 , Agt , Agtr1a , Agtr1b , Agtr2 , Anpep , Atp6ap2 , Cma1 , Cpa3 , Ctsa , Ctsg , Enpep , Igf2r , Lnpep , Mas1 , Mcpt8l2 , Mcpt8l3 , Mme , Nln , Ren , Renbp , Rnpep , Thop1
sialic acid storage disease pathwayRenbp
sotalol pharmacodynamics pathwayAgtr1a
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
spirapril pharmacokinetics pathwayAce
systemic lupus erythematosus pathwayCtsg , Mcpt8l2 , Mcpt8l3
Tay-Sachs disease pathwayRenbp
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
timolol pharmacodynamics pathwayAgtr1a
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
trandolapril pharmacokinetics pathwayAce
Trypanosoma brucei infection pathwayThop1
Trypanosoma cruzi infection pathwayAce
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
verapamil pharmacodynamics pathwayAgtr1a
Phenotype Annotations Associated with Genes in the renin-angiotensin cascade pathway

References Associated with the renin-angiotensin cascade pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: