NUCLEAR FACTOR KAPPA B SIGNALING PATHWAY (PW:0000499)

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Description

Nuclear Factor kappa B (NF-kB) signaling pathway is essential for the proper functioning of the immune system. NF-kB pathway regulates the expression of cytokines, growth factors and other regulatory proteins; its signaling is set in motion in response to the activation of upstream pathways. Tumor necrosis factor (Tnf) alpha via tumor necrosis receptor R1, interleukin-1 via interleukin receptor 1 and lipopolysaccharide (LPS) triggered Toll-like receptors pathways converge on the activation of th

Pathway Diagram:

Elsevier Inc. Nfkb2 RELB K63-ubiquitin M1-Ubiquitin M1-ubiquitination miRNA in NF-kB LUBAC complex SCF ubiquitin ligase complex K63-polyubiquitination NF-kB target genes Tnf receptor superfamily, other upstream activators adapters adapters ---- Ikbkg adapters --+> Map3k14 SCF ubiquitin ligase complex ---| Nfkbia Rel Map3k14 --+> Chuk Chuk Map3k14 Ikbkb ---> Nfkbia Ikbkb ---> Nfkbib Ikbkb ---> Nfkbie Nfkbia Ikbkb Nfkbib K63-ubiquitin ---- Tab3 K63-ubiquitin ---- Tab2 Ikbkg ---- K63-ubiquitin Ikbkg Map3k7 Nfkbie Ikbkb ---- Ikbkg Ikbkg ---- M1-Ubiquitin Nfkbia ---- Rela Nfkbia ---| Rela Nfkb1 ---- Nfkbia Nfkbib ---- Rela Nfkbib ---| Rela Chuk ---- Ikbkg SCF ubiquitin ligase complex ---| Nfkbib SCF ubiquitin ligase complex ---| Nfkbie Chuk ---- Ikbkb Chuk --+> Nfkb2 NF-kB target genes ---> Nfkbia Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb1 ---> NF-kB target genes Rel ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes miRNA in NF-kB ---> NF-kB target genes NF-kB target genes ---> miRNA in NF-kB Rela Nfkb1 Map3k7 --+> Ikbkb LUBAC complex ---> Ikbkg Cyld Tab2 Tab3 Tab1 Cyld ---| K63-polyubiquitination adapters --+> Map3k7 Cyld ---| Map3k7
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Genes in Pathway:

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nuclear factor kappa B signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6484113
G Bcl10 B-cell CLL/lymphoma 10 JBrowse link 2 251,805,392 251,814,957 RGD:6484113
G Bcl3 B-cell CLL/lymphoma 3 JBrowse link 1 80,730,758 80,745,273 RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:5490225
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:2292172
RGD:6484113
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:6484113
G Csnk2a2 casein kinase 2 alpha 2 JBrowse link 19 9,972,537 10,012,043 RGD:6484113
G Csnk2b casein kinase 2 beta JBrowse link 20 5,108,692 5,113,675 RGD:6484113
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:5490225
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:6484113
RGD:7800735
RGD:7800734
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:2292172
RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:2292172
RGD:6484113
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128786
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6484113
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:6484113
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:2292172
RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490225
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:2292172
RGD:6484113
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:2292172
RGD:6484113
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:2292172
RGD:6484113
G Nfkbib NFKB inhibitor beta JBrowse link 1 86,941,073 86,948,845 RGD:2292172
G Nfkbie NFKB inhibitor epsilon JBrowse link 9 17,828,405 17,835,240 RGD:2292172
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6484113
G Ran RAN, member RAS oncogene family JBrowse link 12 31,319,556 31,324,105 RGD:6484113
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:7800730
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:5490225
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:2292172
RGD:6484113
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:2292172
RGD:6484113
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:6484113
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:6484113
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:7800730
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7800730
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:5490225
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490225
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490225
G Tab3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490225
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6484113
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6484113
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 JBrowse link 2 240,626,198 240,655,874 RGD:6484113
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupmiRNA in NF-kB
Gene GroupNF-kB target geneslink to a comprehensive list of NF-kB targets and website
ComplexLUBAC complexM1-ubiqutin
ComplexSCF ubiquitin ligase complextargets Nf-kB inhibitory proteins for degradation

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the nuclear factor kappa B signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
adenosine signaling pathwayChuk , Ikbkb , Nfkb1 , Nfkb2 , Nfkbia , Pik3ca
aldosterone signaling pathwayPik3ca , Pik3r1 , Prkca
allograft rejection pathwayTnf
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered Reelin signaling pathwaySrc
altered ubiquitin/proteasome degradation pathwayUbe2d3
Alzheimer disease pathwayTnf , Tnfrsf1a , Ube2d3
amyotrophic lateral sclerosis disease pathwayMapk14 , Tnf , Tnfrsf1a
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAtm , Birc2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
asthma disease pathwayTnf
ataxia telangiectasia-mutated (ATM) signaling pathwayAtm
B cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Malt1 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Syk
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2
calcium/calcium-mediated signaling pathwayPrkca
cell cycle pathway, mitoticAtm , Cul1 , Rbx1 , Skp1
ceramide signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
chemokine mediated signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
colorectal cancer pathwayPik3ca , Pik3r1
corticotropin-releasing hormone signaling pathwayArrb2
CRM1 export pathwayRan , Xpo1
cytokine mediated signaling pathwayTnf , Tnfrsf1a
dilated cardiomyopathy pathwayTnf
dopamine signaling pathwaySrc
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayArrb2 , Lck , Mapk14 , Prkca , Src , Syk
endocytosis pathwayArrb2 , Src , Traf6
endometrial cancer pathwayPik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayCul1 , Rbx1 , Skp1 , Ube2d3
endothelin signaling pathwayMapk14 , Prkca , Src
Entamoeba histolyca infection pathwayNfkb1 , Pik3ca , Pik3r1 , Prkca , Rela , Tnf
ephrin - ephrin receptor bidirectional signaling axisLck , Map3k7 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayPik3ca , Pik3r1 , Prkca , Src
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayMapk14 , Nfkb1 , Pik3r1
estrogen signaling pathwaySrc
FasL mediated signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Mapk14 , Pik3ca , Pik3r1 , Src , Syk
Fc epsilon receptor mediated signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Syk , Tnf
Fc gamma receptor mediated signaling pathwayPik3ca , Pik3r1 , Prkca , Syk
fibroblast growth factor signaling pathwayPik3ca , Pik3r1 , Src
glioma pathwayPik3ca , Pik3r1 , Prkca
glutamate signaling pathwayPrkca
glypican signaling pathwayLck , Src
gonadotropin-releasing hormone signaling pathwayMapk14 , Prkca , Src
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1 , Syk
Hedgehog signaling pathwayArrb2 , Btrc , Pik3ca , Pik3r1 , Sspo , Xpo1
hepatitis C virus infection pathwayChuk , Ikbkb , Ikbkg , Irf1 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
homologous recombination pathway of double-strand break repairAtm
hypertrophic cardiomyopathy pathwayTnf
hypoxia inducible factor pathwayRbx1
influenza A virus infection pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a , Xpo1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca
insulin-like growth factor signaling pathwayPik3ca , Pik3r1
integrin mediated signaling pathwaySharpin
interleukin-1 signaling pathwayChuk , Erc1 , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Traf6
interleukin-12 signaling pathwayLck , Mapk14 , Nfkb1 , Nfkb2 , Rela , Relb , Ripk2
interleukin-2 signaling pathwayLck , Mapk14 , Pik3ca , Pik3r1 , Syk
interleukin-23 signaling pathwayNfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf
interleukin-27 signaling pathwayTnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayMapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayIrf1 , Mapk14 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayIrf1 , Pik3ca , Pik3r1
kinin signaling pathwayArrb2
Leishmania infection pathwayMap3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
long term depressionPrkca
long term potentiationPrkca
measles infection pathwayChuk , Csnk2a1 , Csnk2a2 , Csnk2b , Map3k7 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Traf6
melanoma pathwayPik3ca , Pik3r1
microRNA pathwayRan
mitochondrial autophagy pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Src
mitogen activated protein kinase signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Prkca , Rela , Tnf , Tnfrsf1a , Traf6
mTOR signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca , Sspo
Mycobacterium tuberculosis infection pathwayBcl10 , Malt1 , Mapk14 , Nfkb1 , Nod2 , Rela , Ripk2 , Src , Syk , Tnf , Tnfrsf1a , Traf6
N-cadherin signaling pathwayPik3ca , Pik3r1
neddylation pathwayCul1 , Rbx1
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Ripk2 , Traf6
NOD-like receptor signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nod2 , Rela , Ripk2 , Tnf , Traf6
non-small cell lung cancer pathwayPik3ca , Pik3r1 , Prkca
Notch signaling pathwayCul1 , Skp1 , Sspo
nuclear factor kappa B signaling pathwayArrb2 , Atm , Bcl10 , Bcl3 , Birc2 , Btrc , Chuk , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Cyld , Erc1 , Ikbkb , Ikbkg , Irf1 , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Nfkbia , Nfkbib , Nfkbie , Nod2 , Pik3ca , Pik3r1 , Prkca , Ran , Rbck1 , Rbx1 , Rel , Rela , Relb , Ripk2 , Rnf31 , Sharpin , Skp1 , Src , Sspo , Syk , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a , Traf6 , Ube2d3 , Xpo1
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Cul1 , Ikbkb , Rbx1 , Skp1
nucleotide excision repair pathwayRbx1
p38 MAPK signaling pathwayAtm , Irf1 , Map3k7 , Mapk14 , Tab1 , Tab2 , Traf6
p53 signaling pathwayAtm , Mapk14
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayLck , Pik3ca , Pik3r1 , Src , Syk
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1 , Prkca
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3r1 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3r1
Plasmodium infection pathwayTnf
platelet-derived growth factor signaling pathwayCsnk2a1 , Lck , Pik3ca , Pik3r1 , Prkca , Src
primary immunodeficiency disease pathwayIkbkg , Lck
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1 , Rbx1
protein kinase C (PKC) signaling pathwayLck , Prkca
Reelin signaling pathwayPik3ca , Pik3r1 , Src
renal cell cancer pathwayPik3ca , Pik3r1 , Rbx1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
rheumatoid arthritis disease pathwayTnf
ribosome biogenesis pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Ran , Xpo1
RNA transport pathwayRan , Xpo1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Traf6
somatostatin signaling pathwaySrc
sphingosine 1-phosphate signaling pathwayMapk14 , Src
syndecan signaling pathwayPrkca , Src
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Tnf
Toll-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Tnf , Traf6
Toxoplasma gondii infection pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayCul1 , Rbx1 , Skp1 , Tnf
Trypanosoma brucei infection pathwayPrkca , Tnf
Trypanosoma cruzi infection pathwayChuk , Ikbkb , Ikbkg , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
tumor necrosis factor mediated signaling pathwayBirc2 , Chuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rbck1 , Rela , Rnf31 , Sharpin , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a
type 1 diabetes mellitus pathwayTnf
type 2 diabetes mellitus pathwayIkbkb , Pik3ca , Pik3r1 , Tnf
type II interferon signaling pathwayIrf1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayBirc2 , Btrc , Cul1 , Rbx1 , Skp1 , Src , Traf6 , Ube2d3
vascular endothelial growth factor signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Src
visual phototransduction pathwayArrb2
Wnt signaling pathwayBtrc , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Map3k7 , Prkca , Rbx1 , Skp1
Wnt signaling, canonical pathwayBtrc
Wnt signaling, non-canonical pathwayArrb2 , Map3k7 , Tab1 , Tab2
Phenotype Annotations Associated with Genes in the nuclear factor kappa B signaling pathway

References Associated with the nuclear factor kappa B signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: