ALTERED TRANSFORMING GROWTH FACTOR-BETA SMAD DEPENDENT SIGNALING PATHWAY (PW:0000614)

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Description

Transforming growth factor-beta superfamily mediated pathways are central regulators of proliferation and survival, migration and differentiation, angiogenesis, embryonic development and wound healing. The transforming growth factor-beta (Tgf-b) Smad-dependent pathway is one of the best characterized modules of the Tgf-b superfamily signaling. Deregulation of the Tgf-b Smad dependent signaling renders the otherwise tumor suppressive and growth inhibitory pathway, a pro-growth and pro-tumo

Pathway Diagram:

Ariadne Genomics Inc. Tgf-beta target genes Transcription factors/co-activators colorectal cancer pathway Colorectal Neoplasms Pancreatic Neoplasms Prostatic Neoplasms Smad7 Smurf2 Tgf-beta target genes ---> Colorectal Neoplasms Smad3 Smad2 Smad7 ---| Tgfbr1 Fkbp1a Zfyve9 Dcn A2m Tgfbr3 Smad3 ---- Zfyve9 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Smad7 ---| Tgfbr1 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgf-beta target genes ---> Smad7 Smurf1 Smad4 Tgf-beta target genes ---> colorectal cancer pathway Tgf-beta target genes ---> Pancreatic Neoplasms Translocated Smad ---> Tgf-beta target genes Tgfbr2 Tgfb1 ---- Tgfbr2 Tgfb1 Tgfbr1 Tgfb1 ---- Tgfbr1 Tgf-beta target genes ---> Prostatic Neoplasms Translocated Smad
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Genes in Pathway:

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altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:5490966
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:5490965
RGD:5490966
RGD:2308865
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2299005
RGD:2306282
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2299005
RGD:2306282
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2299005
RGD:2306282
RGD:2308865
RGD:5490966
RGD:5490965

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaycolorectal cancer pathwayColorectal cancer are malignant tumors of the colon and rectum
Gene GroupTgf-beta target genestransforming growth factor, beta target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Disease TermsGene Symbols
Genital Diseases, FemaleSmad2
Pathway Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Bone morphogenetic proteins signaling pathwaySmad4 , Smad7
cell cycle pathway, mitoticSmad2 , Smad3 , Smad4 , Tgfb1
ceramide signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
chronic myeloid leukemia pathwaySmad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
colorectal cancer pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
cytokine mediated signaling pathwayTgfb1 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1
endocytosis pathwaySmad2 , Smad3 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Entamoeba histolyca infection pathwayTgfb1
glypican signaling pathwaySmad2 , Tgfb1 , Tgfbr2
hypertrophic cardiomyopathy pathwayTgfb1
hypoxia inducible factor pathwaySmad3 , Smad4
interleukin-27 signaling pathwayTgfb1
Leishmania infection pathwayTgfb1
mitogen activated protein kinase signaling pathwayTgfb1 , Tgfbr1 , Tgfbr2
Mycobacterium tuberculosis infection pathwayTgfb1
pancreatic cancer pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
Plasmodium infection pathwayTgfb1
renal cell cancer pathwayTgfb1
rheumatoid arthritis disease pathwayTgfb1
syndecan signaling pathwayTgfb1
Toxoplasma gondii infection pathwayTgfb1
transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Trypanosoma cruzi infection pathwaySmad2 , Smad3 , Tgfb1 , Tgfbr1 , Tgfbr2
type II interferon signaling pathwaySmad7
Wnt signaling pathwaySmad2 , Smad3 , Smad4
Phenotype Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Phenotype TermsGene Symbols
liver fibrosisSmad3

References Associated with the altered transforming growth factor-beta Smad dependent signaling pathway:

Ontology Path Diagram:

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