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In the pancreatic alpha cells of the islets of Langerhans, glucagon is processed from the precursor proglucagon by the prohormone convertase 2 (PC-2). In the intestinal L cells and brainstem neurons, prohormone convertase 1 (PC-1) processes the same precursor molecule into several peptides distinct from glucagon, including the glucagon-like peptides (GLP) 1 and 2. The resulting peptides bind to cognate G-protein coupled receptors (GPCR) to elicit distinct responses. When the levels of circulatin

Pathway Diagram:

Ariadne Genomics Inc. expression of gluconeogenic genes gluconeogenesis pathway glycogen degradation pathway glycogen biosynthetic pathway glycolysis pathway protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family Adcy6 Adcy5 protein kinase A (PKA) signaling pathway --+> expression of gluconeogenic genes reduced F2, 6P levels protein kinase A (PKA) signaling pathway --+> gluconeogenesis pathway protein kinase A (PKA) signaling pathway ---| glycolysis pathway ATP ---> cAMP Gnas --+> Adcy6 Gnas --+> Adcy5 cAMP --+> protein kinase A (PKA) signaling pathway cAMP ATP Gnas Gcg Gcgr ---- Gnas Gcg ---- Gcgr protein kinase A (PKA) signaling pathway --+> glycogen degradation pathway protein kinase A (PKA) signaling pathway ---| glycogen biosynthetic pathway Gcgr

Genes in Pathway:

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glucagon signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:2315004
G Adcy6 adenylate cyclase 6 JBrowse link 7 140,270,678 140,291,722 RGD:2315004
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:2315015
G Gcgr glucagon receptor JBrowse link 10 109,707,863 109,716,253 RGD:1625210
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:1625210

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaygluconeogenesis pathway
Pathwayglycogen biosynthetic pathway
Pathwayglycolysis pathway
Pathwayglycogen degradation pathway
PathwayG protein mediated signaling via Galphas familyBased on sequence similarity, the Galpha genes have been grouped into four classes. Effectors of activated Galphas are adenylyl cyclases that catalyzed the formation of cAMP
Small MoleculecAMPcAMP binding to the PKA complex leads to dissociation of the catalytic subunits
Pathwayprotein kinase A (PKA) signaling pathwayProtein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the second messenger cAMP signal

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the glucagon signaling pathway
Pathway TermsGene Symbols
adenosine signaling pathwayGnas
bile acid transport pathwayAdcy5 , Adcy6 , Gnas
calcium/calcium-mediated signaling pathwayGnas
chemokine mediated signaling pathwayAdcy5 , Adcy6
corticotropin-releasing hormone signaling pathwayGnas
dilated cardiomyopathy pathwayAdcy5 , Adcy6 , Gnas
dopamine signaling pathway via D1 family of receptorsAdcy5 , Gnas
dopamine signaling pathway via D2 family of receptorsAdcy5
endothelin signaling pathwayAdcy5 , Adcy6
Entamoeba histolyca infection pathwayGnas
epinephrine signaling pathway via adrenergic receptor betaGnas
follicle-stimulating hormone signaling pathwayGnas
forkhead class A signaling pathwayGcg
G protein mediated signaling pathway via Galphai familyAdcy5
G protein mediated signaling pathway via Galphas familyAdcy5 , Adcy6 , Gcgr , Gnas
glucagon signaling pathwayAdcy5 , Adcy6 , Gcg , Gcgr , Gnas
glutamate signaling pathwayAdcy5 , Adcy6 , Gnas
gonadotropin-releasing hormone signaling pathwayAdcy5 , Adcy6 , Gnas
histamine signaling pathway, immunologicalGnas
long term depressionGnas
luteinizing hormone signaling pathwayGnas
melanocortin system pathwayGnas
prostaglandin D2 signaling pathwayGnas
prostaglandin I2 signaling pathwayGnas
protein kinase A (PKA) signaling pathwayAdcy5 , Adcy6
purine metabolic pathwayAdcy5 , Adcy6
serotonin signaling pathway via receptors engaging G alphas protein familyGnas
Trypanosoma cruzi infection pathwayGnas
vasopressin signaling pathwayAdcy6 , Gnas
vasopressin signaling pathway via receptor type 2Adcy6 , Gnas

References Associated with the glucagon signaling pathway:

Ontology Path Diagram:

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