FASL MEDIATED SIGNALING PATHWAY (PW:0000681)

View Ontology Report

Description

FasL mediated signaling is one of the major extrinsic apoptotic pathways engaging the death receptors. FasL (official symbol Faslg) and its receptor Fas, also known as CD95/APO-1, belong to the tumor necrosis superfamily (TNF) of ligands and receptors. The receptor contains an extracellular CRD (cysteine-rich domain) while the cytoplasmic part contains a DD (death domain) responsible for the interaction with adapter/effector proteins. Fas, which is ubiquitously expressed, is found at the plasma

Pathway Diagram:

Ariadne Genomics Inc. caspase targets Fadd Faslg Fas Bid Casp7 ---> caspase targets Casp7 ---> caspase targets intrinsic apoptotic pathway Cflar ---| Casp8 Casp8 Cflar clustering Fas ---- Faslg Cflar ---- Fadd Casp8 ---> Bid Casp8 --+> Bid Casp8 --+> Casp7 Casp8 ---> Casp7 Casp8 ---> Casp3 Casp8 --+> Casp3 Casp7 Casp3 Casp3 ---> caspase targets Casp3 ---> caspase targets Fadd ---- Fas Casp8 ---- Fadd
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
FasL mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:2314002
RGD:6484113
RGD:4143196
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6484113
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:6484113
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:4143196
RGD:6484113
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:4143196
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:2314002
RGD:6484113
RGD:4143196
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:4143196
RGD:8662854
RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:6484113
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:6484113
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:4143196
RGD:6484113
G Faim2 Fas apoptotic inhibitory molecule 2 JBrowse link 7 141,158,769 141,185,781 RGD:6484113
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:2314002
RGD:8662854
RGD:6484113
RGD:4143196
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:2314002
RGD:6484113
RGD:4143196
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
G Rfc1 replication factor C subunit 1 JBrowse link 14 44,627,528 44,702,205 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6484113
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupCaspase targetscaspage target genes.
Pathwayintrinsic apoptotic pathwayintrinsic apoptotic pathway

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the FasL mediated signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
adenosine signaling pathwayAkt1 , Chuk , Ikbkb , Map2k6 , Map2k7 , Map3k1 , Mapk11 , Mapk8 , Pdpk1 , Pik3ca
aldosterone signaling pathwayPdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
allograft rejection pathwayFas , Faslg
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
altered Reelin signaling pathwaySrc
Alzheimer disease pathwayBid , Casp3 , Casp7 , Casp8 , Fadd , Fas
amyotrophic lateral sclerosis disease pathwayBid , Casp3 , Map2k6 , Mapk11 , Mapk14
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Bid , Birc2 , Birc3 , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Fas , Faslg , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
autoimmune thyroid disease pathwayFas , Faslg
B cell receptor signaling pathwayAkt1 , Btk , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Syk
c-Jun N-terminal kinases MAPK signaling pathwayMap2k7 , Map3k1 , Mapk10 , Mapk8 , Mapk9
ceramide signaling pathwayAkt1 , Bid , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1
chemokine mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
chronic myeloid leukemia pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
clathrin-dependent synaptic vesicle endocytosisCltc
colorectal cancer pathwayAkt1 , Casp3 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
cytokine mediated signaling pathwayFas , Faslg
DNA replication pathwayRfc1
dopamine signaling pathwaySrc
E-cadherin signaling pathwayAkt1 , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayAkt1 , Mapk11 , Mapk14 , Src , Syk
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayCltc , Src
endometrial cancer pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Mapk14 , Mapk8 , Src
Entamoeba histolyca infection pathwayCasp3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
ephrin - ephrin receptor bidirectional signaling axisMapk8 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
erythropoietin signaling pathwayBtk , Mapk14 , Mapk8 , Pik3r1
estrogen signaling pathwaySrc
extrinsic apoptotic pathwayCasp3 , Casp7 , Casp8 , Fas , Faslg
FasL mediated signaling pathwayAkt1 , Bid , Birc2 , Birc3 , Btk , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Cltc , Ezr , Fadd , Faim2 , Fas , Faslg , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Rfc1 , Ripk1 , Smpd1 , Src , Syk
Fc epsilon receptor mediated signaling pathwayAkt1 , Btk , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Syk
Fc gamma receptor mediated signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Syk
fibroblast growth factor signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3r1 , Src
forkhead class A signaling pathwayAkt1
glioma pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
glypican signaling pathwayMapk8 , Mapk9 , Src
gonadotropin-releasing hormone signaling pathwayMap2k6 , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Src
graft-versus-host disease pathwayFas , Faslg
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1 , Syk
Hedgehog signaling pathwayAkt1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
Huntington disease pathwayCasp3 , Casp8 , Cltc
hypoxia inducible factor pathwayAkt1
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Fas , Faslg , Ikbkb , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1
insulin signaling pathwayAkt1 , Ikbkb , Mapk10 , Mapk8 , Mapk9 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
insulin-like growth factor signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3r1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Map2k6 , Mapk8 , Pik3ca , Pik3r1
interleukin-12 signaling pathwayFaslg , Map2k6 , Mapk14
interleukin-2 signaling pathwayMapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Syk
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Mapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBid , Casp3 , Casp7 , Fas
Jak-Stat signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Leishmania infection pathwayMapk11 , Mapk14
measles infection pathwayAkt1 , Chuk , Fas , Faslg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
melanoma pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
mismatch repair pathwayRfc1
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Casp3 , Chuk , Fas , Faslg , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9
mTOR signaling pathwayAkt1 , Ikbkb , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Mycobacterium tuberculosis infection pathwayAkt1 , Bid , Casp3 , Casp8 , Fadd , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Src , Syk
myocarditis pathwayBid , Casp3 , Casp8
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayAkt1 , Faslg , Ikbkb , Map2k7 , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
NOD-like receptor signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9
non-small cell lung cancer pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
nuclear factor kappa B signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Mapk14 , Pik3ca , Pik3r1 , Src , Syk
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
nucleotide excision repair pathwayRfc1
p38 MAPK signaling pathwayMap2k6 , Map3k1 , Mapk11 , Mapk14
p53 signaling pathwayAkt1 , Bid , Casp3 , Casp8 , Fas , Mapk14 , Mapk8 , Mapk9
pancreatic cancer pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
parathyroid hormone signaling pathwayEzr
Parkinson disease pathwayCasp3
phosphatidylinositol 3-kinase class I signaling pathwayBtk , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src , Syk
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Chuk , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
primary immunodeficiency disease pathwayBtk , Ikbkg
prostate cancer pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
protein kinase A (PKA) signaling pathwayEzr
protein kinase C (PKC) signaling pathwayBtk , Pdpk1
Reelin signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1 , Src
renal cell cancer pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Ripk1
Rho/Rac/Cdc42 mediated signaling pathwayMapk8
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayAkt1 , Birc2 , Birc3 , Chuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
somatostatin signaling pathwaySrc
sphingolipid metabolic pathwaySmpd1
sphingosine 1-phosphate signaling pathwayAkt1 , Mapk14 , Mapk8 , Src
syndecan signaling pathwayCasp3 , Ezr , Mapk8 , Src
T cell receptor signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Map2k7 , Mapk11 , Mapk14 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1
titanium dioxide nanoparticle response pathwayCasp3 , Casp8 , Fas
Toll-like receptor signaling pathwayAkt1 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
Toxoplasma gondii infection pathwayAkt1 , Birc2 , Birc3 , Casp3 , Casp8 , Chuk , Ikbkb , Ikbkg , Map2k6 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1
transforming growth factor-beta Smad dependent signaling pathwayPdpk1
Trypanosoma brucei infection pathwayFas , Faslg
Trypanosoma cruzi infection pathwayAkt1 , Casp8 , Cflar , Chuk , Fadd , Fas , Faslg , Ikbkb , Ikbkg , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tumor necrosis factor mediated signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k7 , Map3k1 , Ripk1 , Smpd1
type 1 diabetes mellitus pathwayFas , Faslg
type 2 diabetes mellitus pathwayIkbkb , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
type II interferon signaling pathwayAkt1 , Map3k1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayBirc2 , Birc3 , Map3k1 , Src
vascular endothelial growth factor signaling pathwayAkt1 , Map2k6 , Mapk11 , Mapk14 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Wnt signaling pathwayMapk10 , Mapk8 , Mapk9
Wnt signaling, non-canonical pathwayMapk10 , Mapk8 , Mapk9
Phenotype Annotations Associated with Genes in the FasL mediated signaling pathway
Phenotype TermsGene Symbols
neurodegenerationFaslg

References Associated with the FasL mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: