TRAIL MEDIATED SIGNALING PATHWAY (PW:0000682)

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Description

Trail mediated signaling is one of the major extrinsic apoptotic pathway engaging the death receptors. Trail, also known as Apo2L (official symbol Tnfsf10) and its receptors belong the to the tumor necrosis superfamily (TNF) of ligands and receptors. Of the five receptors that can bind Tnfsf10, only two can induce apoptosis; they both contain the DD domain (death domain) in their cytoplasmic part while the extracellular part contains the CCG (

Pathway Diagram:

Ariadne Genomics Inc. caspase targets Bid Fadd Casp3 Casp7 ---> caspase targets Casp3 ---> caspase targets Casp8 ---- Fadd Fadd ---- TNFRSF10A intrinsic apoptotic pathway Casp8 ---> Bid Fadd ---- Tnfrsf10b TNFRSF10A ---- Tnfsf10 Tnfrsf10b ---- Tnfsf10 TNFRSF10A Cflar ---- Fadd Casp8 ---> Casp3 Casp8 ---> Casp7 Casp7 ---> caspase targets Casp3 ---> caspase targets Casp7 Casp8 Cflar Tnfrsf10b Tnfsf10 Cflar ---| Casp8 Casp8 --+> Casp7 Casp8 --+> Casp3 Casp8 --+> Bid
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Genes in Pathway:

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Trail mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:4143170
RGD:4143171
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:4143170
RGD:4143171
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:4143171
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:4143170
RGD:6484113
RGD:4143171
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:4143170
RGD:6484113
RGD:4143171
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Dap3 death associated protein 3 JBrowse link 2 188,225,607 188,255,324 RGD:6484113
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:4143170
RGD:6484113
RGD:4143171
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6484113
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:4142856
RGD:4143170
RGD:4143171
RGD:6484113
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:2312745
RGD:6484113
RGD:4143171
RGD:4143170
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupCaspase targetstargets for caspase

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the Trail mediated signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
adenosine signaling pathwayChuk , Ikbkb , Map3k1 , Mapk1 , Mapk8 , Pik3ca
aldosterone signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
Alzheimer disease pathwayBid , Casp3 , Casp7 , Casp8 , Fadd , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBid , Casp3
apoptotic cell death pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tnfrsf10b , Tnfsf10 , Tradd , Traf2
B cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
bladder cancer pathwayMapk1 , Mapk3
Bone morphogenetic proteins signaling pathwayMapk1
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map3k1 , Mapk8 , Traf2
ceramide signaling pathwayBid , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1 , Tradd , Traf2
chemokine mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
colorectal cancer pathwayCasp3 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
cytokine mediated signaling pathwayTnfsf10
E-cadherin signaling pathwayPik3ca , Pik3r1
endometrial cancer pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Endoplasmic Reticulum-associated degradation pathwayMapk8 , Traf2
endothelin signaling pathwayMapk1 , Mapk3 , Mapk8
Entamoeba histolyca infection pathwayCasp3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
ephrin - ephrin receptor bidirectional signaling axisMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
erythropoietin signaling pathwayMapk8 , Pik3r1
extrinsic apoptotic pathwayCasp3 , Casp7 , Casp8
FasL mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1
Fc epsilon receptor mediated signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc gamma receptor mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3r1
glioma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
glutamate signaling pathwayMapk1 , Mapk3
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
glypican signaling pathwayMapk8
gonadotropin-releasing hormone signaling pathwayMap2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3r1
Hedgehog signaling pathwayPik3ca , Pik3r1
hepatitis C virus infection pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd , Traf2
Huntington disease pathwayCasp3 , Casp8
inflammatory response pathwayMapk8
influenza A virus infection pathwayIkbkb , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Tnfrsf10b , Tnfsf10
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin signaling pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
insulin-like growth factor signaling pathwayPik3ca , Pik3r1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Pik3ca , Pik3r1
interleukin-2 signaling pathwayMapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayPik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayMap2k4 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBid , Casp3 , Casp7
Jak-Stat signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Leishmania infection pathwayMapk1 , Mapk3
long term depressionMapk1 , Mapk3
long term potentiationMapk1 , Mapk3
measles infection pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Tnfrsf10b , Tnfsf10
melanoma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
mitogen activated protein kinase signaling pathwayCasp3 , Chuk , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Traf2
mTOR signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Mycobacterium tuberculosis infection pathwayBid , Casp3 , Casp8 , Fadd , Mapk1 , Mapk3 , Mapk8 , Tradd
myocarditis pathwayBid , Casp3 , Casp8
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
neurotrophic factor signaling pathwayIkbkb , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
NOD-like receptor signaling pathwayCasp8 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8
non-small cell lung cancer pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
p38 MAPK signaling pathwayMap3k1 , Traf2
p53 signaling pathwayBid , Casp3 , Casp8 , Mapk8
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Parkinson disease pathwayCasp3
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
primary immunodeficiency disease pathwayIkbkg
prion diseases pathwayMapk1 , Mapk3
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Reelin signaling pathwayMapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Ripk1 , Tradd , Traf2
Rho/Rac/Cdc42 mediated signaling pathwayMap2k4 , Mapk8
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung cancer pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Traf2
sphingolipid metabolic pathwaySmpd1
sphingosine 1-phosphate signaling pathwayMapk1 , Mapk3 , Mapk8
syndecan signaling pathwayCasp3 , Mapk1 , Mapk3 , Mapk8
T cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1 , Mapk1 , Mapk3
thyroid cancer pathwayMapk1 , Mapk3
titanium dioxide nanoparticle response pathwayCasp3 , Casp8
Toll-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd
Toxoplasma gondii infection pathwayCasp3 , Casp8 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Dap3 , Fadd , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1 , Tnfrsf10b , Tnfsf10 , Tradd , Traf2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3
Trypanosoma cruzi infection pathwayCasp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tumor necrosis factor mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Ripk1 , Smpd1 , Tradd , Traf2
type 2 diabetes mellitus pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
type II interferon signaling pathwayMap3k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayMap3k1
vascular endothelial growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Wnt signaling pathwayMapk8
Wnt signaling, non-canonical pathwayMapk8

References Associated with the Trail mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: