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Norepinephrine and epinephrine, whose synthesis and release are prompted by various but distinct stresses, act as neurotransmitters and hormones that signal via various adrenergic receptors, G-protein coupled receptors (GPCR) that couple to distinct G alpha subunits of heterotrimeric G proteins. The beta receptors, for which epinephrine appears to be a favorite agonist, couple to the Gs alpha subunit leading to activation of adenylyl cyclases, cAMP production and subsequent triggering of PKA sig

Pathway Diagram:

Ariadne Genomics Inc. epinephrine prompting stresses epinephrine receptor internalization receptor - G protein uncoupling Gnas G protein mediated signaling pathway via Galphas family beta-arrestin mediated signaling epinephrine biosynthetic pathway protein kinase A (PKA) signaling pathway cAMP --+> protein kinase A (PKA) signaling pathway cAMP G protein mediated signaling pathway via Galphas family --+> cAMP Snx13 ---| Gnas Adrb2 ---- epinephrine Adrb1 ---- epinephrine receptor - G protein uncoupling ---| G protein mediated signaling pathway via Galphas family Grk5 ---| Adrb2 Grk5 ---| Adrb1 Adrbk1 ---| Adrb2 Adrbk1 ---| Adrb1 Grk5 Adrbk1 Snx13 Adrb2 ---- Gnas Adrb1 ---- Gnas Adrb2 ---- Arrb1 Adrb2 ---- Arrb2 Adrb1 ---- Arrb2 Adrb1 ---- Arrb1 Adrb1 Adrb2 Arrb1 Arrb2 Arrb2 ---> beta-arrestin mediated signaling Arrb1 ---> beta-arrestin mediated signaling epinephrine prompting stresses ---> epinephrine epinephrine release

Genes in Pathway:

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epinephrine signaling pathway via adrenergic receptor beta term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:4140391
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:4140391
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5135529
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5135529
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:4140391
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:4140391
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:4140391
G Snx13 sorting nexin 13 JBrowse link 6 54,487,626 54,591,716 RGD:4140388

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculecAMPcyclic AMP

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the epinephrine signaling pathway via adrenergic receptor beta
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAdrb1
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Grk5
adenosine signaling pathwayGnas
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAdrb1 , Adrb2
amiodarone pharmacodynamics pathwayAdrb1
amlodipine pharmacodynamics pathwayAdrb1
angiotensin II signaling pathway via AT1 receptorArrb1 , Arrb2 , Grk2 , Grk5
atenolol pharmacodynamics pathwayAdrb1
betaxolol pharmacodynamics pathwayAdrb1
bile acid transport pathwayGnas
bisoprolol pharmacodynamics pathwayAdrb1
bupranolol drug pathwayAdrb1
bupranolol pharmacodynamics pathwayAdrb1
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Grk2
calcium/calcium-mediated signaling pathwayAdrb1 , Adrb2 , Gnas
carvedilol pharmacodynamics pathwayAdrb1
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk5
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Gnas
dilated cardiomyopathy pathwayAdrb1 , Gnas
diltiazem pharmacodynamics pathwayAdrb1
disopyramide pharmacodynamics pathwayAdrb1
dobutamine pharmacodynamics pathwayAdrb1
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Gnas , Grk2 , Grk5
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk5
eicosanoid signaling pathwayArrb2 , Grk2
endocytosis pathwayAdrb1 , Adrb2 , Arrb1 , Arrb2 , Grk2 , Grk5
Entamoeba histolyca infection pathwayGnas
epinephrine signaling pathway via adrenergic receptor betaAdrb1 , Adrb2 , Arrb1 , Arrb2 , Gnas , Grk2 , Grk5 , Snx13
esmolol pharmacodynamics pathwayAdrb1
flecainde pharmacodynamics pathwayAdrb1
follicle-stimulating hormone signaling pathwayGnas
fosphenytoin pharmacodynamics pathwayAdrb1
G protein mediated signaling pathway via Galphai familyAdrb2
G protein mediated signaling pathway via Galphas familyAdrb1 , Adrb2 , Gnas , Grk2 , Snx13
glucagon signaling pathwayGnas
glutamate signaling pathwayGnas , Grk2
gonadotropin-releasing hormone signaling pathwayGnas
Hedgehog signaling pathwayArrb2 , Grk2
histamine signaling pathway, immunologicalGnas
ibutilide pharmacodynamics pathwayAdrb1
isoprenaline pharmacodynamics pathwayAdrb1
isradipine pharmacodynamics pathwayAdrb1
kinin signaling pathwayArrb1 , Arrb2
levobunolol pharmacodynamics pathwayAdrb1
lidocaine pharmacodynamics pathwayAdrb1
long term depressionGnas
luteinizing hormone signaling pathwayGnas
melanocortin system pathwayGnas
metoprolol pharmacodynamics pathwayAdrb1
mexiletine pharmacodynamics pathwayAdrb1
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2
nadolol pharmacodynamics pathwayAdrb1
nebivolol pharmacodynamics pathwayAdrb1
nifedipine pharmacodynamics pathwayAdrb1
nimodipine pharmacodynamics pathwayAdrb1
nisoldipine pharmacodynamics pathwayAdrb1
nitrendipine pharmacodynamics pathwayAdrb1
nuclear factor kappa B signaling pathwayArrb2
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
penbutolol pharmacodynamics pathwayAdrb1
phenytoin pharmacodynamics pathwayAdrb1
pindolol pharmacodynamics pathwayAdrb1
procainamide pharmacodynamics pathwayAdrb1
propranolol pharmacodynamics pathwayAdrb1
prostaglandin D2 signaling pathwayGnas
prostaglandin I2 signaling pathwayGnas
quinidine pharmacodynamics pathwayAdrb1
Rho/Rac/Cdc42 mediated signaling pathwayAdrb1
serotonin signaling pathway via receptors engaging G alphas protein familyGnas
sotalol pharmacodynamics pathwayAdrb1
timolol pharmacodynamics pathwayAdrb1
transforming growth factor-beta Smad dependent signaling pathwayArrb2
Trypanosoma cruzi infection pathwayGnas
vasopressin signaling pathwayGnas
vasopressin signaling pathway via receptor type 2Gnas
verapamil pharmacodynamics pathwayAdrb1
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling, non-canonical pathwayArrb2
Phenotype Annotations Associated with Genes in the epinephrine signaling pathway via adrenergic receptor beta

References Associated with the epinephrine signaling pathway via adrenergic receptor beta:

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